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01-08-2003 | Original

HLA-DR as a marker for increased risk for systemic inflammation and septic complications after cardiac surgery

Authors: Wolfgang Oczenski, Herbert Krenn, Ruth Jilch, Herbert Watzka, Ferdinand Waldenberger, Ursula Köller, Sylvia Schwarz, Robert D. Fitzgerald

Published in: Intensive Care Medicine | Issue 8/2003

Abstract

Objective

This study investigated the predictive value of a decrease in monocyte HLA-DR expression as an early marker for postoperative SIRS and septic complications. We hypothesized that decreased HLA-DR levels in the first 24 h after cardiac surgery is not related to postoperative SIRS/sepsis. We also compared HLA-DR levels of patients with postoperative complications to those with an uncomplicated course.

Design and setting

Prospective observational study in a tertiary care postoperative intensive care unit.

Patients

Eighty five consecutive patients undergoing cardiac surgery.

Measurements and results

Expression of HLA-DR on monocytes was analyzed by flow cytometry using a new quantitative and well standardized technique. Arterial blood samples were collected before induction of anesthesia, immediately after admission to the ICU, and on the first postoperative day. Postoperative HLA-DR expression was significantly decreased in all patients. There were no significant differences in HLA-DR expression during the first 24 h after surgery in patients with uncomplicated course and those developing SIRS or septic complications.

Conclusions

In patients undergoing cardiac surgery the monitoring of pre- and immediate postoperative HLA-DR levels during the first 24 h does not help to predict increased risk for postoperative SIRS/sepsis or infectious complications.

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Title: HLA-DR as a marker for increased risk for systemic inflammation and septic complications after cardiac surgery
Authors: Wolfgang Oczenski
Herbert Krenn
Ruth Jilch
Herbert Watzka
Ferdinand Waldenberger
Ursula Köller
Sylvia Schwarz
Robert D. Fitzgerald
Publication date: 01-08-2003
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 8/2003
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-003-1826-8

At a glance: The STEP trials

Springer Medicine

HLA-DR as a marker for increased risk for systemic inflammation and septic complications after cardiac surgery

Abstract

Objective

Design and setting

Patients

Measurements and results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Design and setting

Patients

Measurements and results

Conclusions

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