Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Intensive Care Medicine
Published in: Intensive Care Medicine 8/2003

01-08-2003 | Brief Report

Fatal septic shock caused by Corynebacterium D2

Authors: Vincent Audard, Maité Garrouste-Orgeas, Benoit Misset, Adel Ben Ali, Olivier Gattolliat, Paul Meria, Jean Carlet

Published in: Intensive Care Medicine | Issue 8/2003

Login to get access

Abstract

Background

Septic shock remains one of the leading causes of mortality in critically ill patients. Optimal management depends on prompt diagnosis with identification of the causative organisms to allow appropriate antibiotic therapy.

Patient

We report the first case of septic shock caused by Corynebacterium D2, a micro-organism that can cause encrusted cystitis and pyelitis of transplanted kidneys or, more rarely, native kidneys. Diagnosis rests on identification of risk factors, positive urine cultures, and computed tomography results. Despite optimal treatment our patient died with persistent encrusted pyelitis.

Conclusions

Corynebacterium D2 is known to cause chronic inflammation of the bladder and proximal urinary tract but can also cause severe septic shock in immunocompetent patients.
Literature
1.
Rangel-Fausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RS (1995) The natural history of the systemic inflammatory response syndrome (SIRS): a prospective study. JAMA 273:117–123PubMed
2.
Morales JM, Aguado JM, Diaz-Gonzales R (1992) Alkaline encrusted pyelitis/cystitis and urinary tract infection due Corynebacterium urealyticum: a new severe complication after renal transplantation. Transplant Proc 24:81–82PubMed
3.
Pitcher DG, Soto A, Soriano F, Valero-Guillen PL (1992) Classification of Corynebacteria associated with human tract infection (group D2) as Corynebacterium urealyticum sp. Nov Int J Syst Bacteriol 42:178
4.
Aguado JM, Morales JM, Solto (1993) Encrusted pyelitis and cystitis by Corynebacterium urealyticum: a new and threatening complication following renal transplant. Transplantation 56:617–622PubMed
5.
Hertig A, Duvic C, Chretien Y (2000) Encrusted pyelitis of native kidney. J Am Soc Nephrol 11:1138–1140PubMed
6.
Meria P, Desgnipper A, Arifi C, Le Du A (1998) Encrusted cystitis and pyelitis. J Urol 160:3–9PubMed
7.
Soriano F, Aguado JM, Ponte C (1990) Urinary tract infection caused by Corynebacterium group D2: report of 82 cases and review. Rev Infect Dis 12:1019–1034PubMed
8.
Marty N, Agueda L, Chabaron G (1989) Adherences et rôle pathogène des Corynebacteries groupe D2 isolées des urines. Rev Fr Lab 63–66
9.
Meria P, Jungers P (2000) Encrusted pyelitis: an underdiagosed condition? Nephrol Dial Transplant 15:943–945
10.
Eschwege P, Hauk M, Blanchet P, Hiesse C, Vieillefond A, Blery M, Charpentier B, Benoit G (1995) Imaging analysis of encrusted cystitis and pyelitis in renal transplantation. Transplant Proc 27:2444PubMed
11.
Langs JC, De Briel D, Sauvage C, Blickle JF, Hakel H (1988) Endocardite à Corynebacterium du groupe D2 à point de départ urinaire. Med Mal Infect :293
12.
Ena J, Besenguer J, Pelaez T, Bouza E (1991) Endocarditis caused by Corynebacterium group D2. J Infect 22:95–96PubMed
13.
Soriano F, Ponte C, Riuz P, Zapardiel J (1993) Non urinary tract infections cased by multiple antibiotic resistant Corynebacterium urealyticum. Clin Infect Dis 17:890–891PubMed
14.
Meria P, Desgrippes A, Fournier A, Arfi C, Martinat L, Teillac P, Le Duc A (1999) The conservative management of Corynebacterium groupe D2 encrusted pyelitis. BJU Int 24:270–275CrossRef
Metadata
Title
Fatal septic shock caused by Corynebacterium D2
Authors
Vincent Audard
Maité Garrouste-Orgeas
Benoit Misset
Adel Ben Ali
Olivier Gattolliat
Paul Meria
Jean Carlet
Publication date
01-08-2003
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 8/2003
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-003-1865-1

Other articles of this Issue 8/2003

Intensive Care Medicine 8/2003 Go to the issue

Original

Long-term outcome in ICU patients:

Editorial

Ventilator-induced lung injury, cytokines, PEEP, and mortality: implications for practice and for clinical trials

Editorial

Is monocyte HLA-DR expression predictive for clinical outcome in sepsis?

Original

Intravenous phosphate in the intensive care unit: More aggressive repletion regimens for moderate and severe hypophosphatemia

Correspondence

Microalbuminuria in severe sepsis: timing is difficult, "normal" levels are uncertain

Original

Is low monocyte HLA-DR expression helpful to predict outcome in severe sepsis?