Skip to main content
Top
Published in: Journal of the International AIDS Society 1/2009

Open Access 01-12-2009 | Commentary

HIV prevention is not enough: child survival in the context of prevention of mother to child HIV transmission

Authors: Louise Kuhn, Moses Sinkala, Don M Thea, Chipepo Kankasa, Grace M Aldrovandi

Published in: Journal of the International AIDS Society | Issue 1/2009

Login to get access

Abstract

Clinical and epidemiologic research has identified increasingly effective interventions to reduce mother to child HIV transmission in resource-limited settings These scientific breakthroughs have been implemented in some programmes, although much remains to be done to improve coverage and quality of these programmes. But prevention of HIV transmission is not enough. It is necessary also to consider ways to improve maternal health and protect child survival.
A win-win approach is to ensure that all pregnant and lactating women with CD4 counts of <350 cells/mm3 have access to antiretroviral therapy. On its own, this approach will substantially improve maternal health and markedly reduce mother to child HIV transmission during pregnancy and delivery and through breastfeeding. This approach can be combined with additional interventions for women with higher CD4 counts, either extended prophylaxis to infants or extended regimens of antiretroviral drugs to women, to reduce transmission even further.
Attempts to encourage women to abstain from all breastfeeding or to shorten the optimal duration of breastfeeding have led to increases in mortality among both uninfected and infected children. A better approach is to support breastfeeding while strengthening programmes to provide antiretroviral therapy for pregnant and lactating women who need it and offering antiretroviral drug interventions through the duration of breastfeeding. This will lead to reduced HIV transmission and will protect the health of women without compromising the health and well-being of infants and young children.
Literature
1.
go back to reference Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O'Sullivan MJ, VanDyke R, Bey M, Shearer W, Jacobson RL, O'Neill E, Bazin B, Delfraissy J-F, Culnane M, Coombs R, Elkins M, Moye J, Stratton P, Balsey J, for The Pediatric AIDS Clinical Trials Group Protocol 076 Study Group: Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. N Engl J Med 1994, 331: 1173–80.CrossRefPubMed Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O'Sullivan MJ, VanDyke R, Bey M, Shearer W, Jacobson RL, O'Neill E, Bazin B, Delfraissy J-F, Culnane M, Coombs R, Elkins M, Moye J, Stratton P, Balsey J, for The Pediatric AIDS Clinical Trials Group Protocol 076 Study Group: Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. N Engl J Med 1994, 331: 1173–80.CrossRefPubMed
2.
go back to reference Dabis F, Msellati A, Meda N, Welffens-Ekra C, You B, Manigart O, Leroy V, Simonon A, Cartoux M, Combe P, Ouangré A, Ramon R, Ky-Zerbo O, Montcho C, Salamon R, Rouzioux C, Perre P, Mandelbrot L: 6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breast fed children in Côte d'Ivoire and Burkina Faso: a double-blind placebo-controlled mutlicentre trial. Lancet 1999, 353: 786–92.CrossRefPubMed Dabis F, Msellati A, Meda N, Welffens-Ekra C, You B, Manigart O, Leroy V, Simonon A, Cartoux M, Combe P, Ouangré A, Ramon R, Ky-Zerbo O, Montcho C, Salamon R, Rouzioux C, Perre P, Mandelbrot L: 6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breast fed children in Côte d'Ivoire and Burkina Faso: a double-blind placebo-controlled mutlicentre trial. Lancet 1999, 353: 786–92.CrossRefPubMed
3.
go back to reference Shaffer N, Chuachoowong R, Mock PA, Bhadrakom C, Siriwasin W, Young NL, Chotpitayasunondh T, Cherskul S, Roongpisuthipong A, Chinayon P, Karon J, Mastro TD, Simonds RJ, on behalf of the Bangkok Collaborative Perinatal HIV Transmission Study Group: Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: a randomized controlled trial. Lancet 1999, 353: 773–80.CrossRefPubMed Shaffer N, Chuachoowong R, Mock PA, Bhadrakom C, Siriwasin W, Young NL, Chotpitayasunondh T, Cherskul S, Roongpisuthipong A, Chinayon P, Karon J, Mastro TD, Simonds RJ, on behalf of the Bangkok Collaborative Perinatal HIV Transmission Study Group: Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: a randomized controlled trial. Lancet 1999, 353: 773–80.CrossRefPubMed
4.
go back to reference Guay LA, Musoke P, Fleming T, Bagenda D, Allen M, Nakabiito C, Sherman J, Bakaki P, Ducar C, Deseyve M, Emel L, Mirochnick M, Fowler MG, Mofenson L, Miotti PG, Dransfield K, Bray D, Mmiro F, Jackson B: Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet 1999, 354: 795–802.PubMed Guay LA, Musoke P, Fleming T, Bagenda D, Allen M, Nakabiito C, Sherman J, Bakaki P, Ducar C, Deseyve M, Emel L, Mirochnick M, Fowler MG, Mofenson L, Miotti PG, Dransfield K, Bray D, Mmiro F, Jackson B: Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet 1999, 354: 795–802.PubMed
5.
go back to reference Taha TE, Kumwenda NI, Hoover DR, Fiscus SA, Kafulafula G, Nkhoma C, Nour S, Chen S, Liomba G, Miotti P, Broadhead RL: Nevirapine and zidovudine at birth to reduce perinatal transmission of HIV in an African setting: a randomized controlled trial. JAMA 2004, 292: 202–9.CrossRefPubMed Taha TE, Kumwenda NI, Hoover DR, Fiscus SA, Kafulafula G, Nkhoma C, Nour S, Chen S, Liomba G, Miotti P, Broadhead RL: Nevirapine and zidovudine at birth to reduce perinatal transmission of HIV in an African setting: a randomized controlled trial. JAMA 2004, 292: 202–9.CrossRefPubMed
6.
go back to reference Gray GE, Urban M, Chersich MF, Bolton C, van Niekerk R, Violari A, Stevens W, McIntyre JA, for the PEP Study Group: A randomized trial of two postexposure prophylaxis regimens to reduce mother-to-child HIV-1 transmission in infants of untreated mothers. AIDS 2005, 19: 1289–97.CrossRefPubMed Gray GE, Urban M, Chersich MF, Bolton C, van Niekerk R, Violari A, Stevens W, McIntyre JA, for the PEP Study Group: A randomized trial of two postexposure prophylaxis regimens to reduce mother-to-child HIV-1 transmission in infants of untreated mothers. AIDS 2005, 19: 1289–97.CrossRefPubMed
7.
go back to reference Lallemant M, Jourdain G, Le CS, Mary JY, Ngo-Giang-Huong N, Koetsawang S, Kanshana S, McIntosh K, Thaineua V, Perinatal HIV Prevention Trial (Thailand) Investigators: Single-dose perinatal nevirapine plus standard zidovudine to prevent mother-to-child transmission of HIV-1 in Thailand. N Engl J Med 2004, 351: 217–28.CrossRefPubMed Lallemant M, Jourdain G, Le CS, Mary JY, Ngo-Giang-Huong N, Koetsawang S, Kanshana S, McIntosh K, Thaineua V, Perinatal HIV Prevention Trial (Thailand) Investigators: Single-dose perinatal nevirapine plus standard zidovudine to prevent mother-to-child transmission of HIV-1 in Thailand. N Engl J Med 2004, 351: 217–28.CrossRefPubMed
8.
go back to reference Tonwe-Gold B, Ekouevi DK, Viho I, mani-Bosse C, Toure S, Coffie PA, Rouet F, Becquet R, Leroy V, El-Sadr WM, Abrams EJ, Dabis F: Antiretroviral treatment and prevention of peripartum and postnatal HIV transmission in West Africa: evaluation of a two-tiered approach. PLOS Medicine 2007, 4: e257.CrossRefPubMed Tonwe-Gold B, Ekouevi DK, Viho I, mani-Bosse C, Toure S, Coffie PA, Rouet F, Becquet R, Leroy V, El-Sadr WM, Abrams EJ, Dabis F: Antiretroviral treatment and prevention of peripartum and postnatal HIV transmission in West Africa: evaluation of a two-tiered approach. PLOS Medicine 2007, 4: e257.CrossRefPubMed
9.
go back to reference Six Week Extended-Dose Nevirapine (SWEN) Study Team: Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India, and Uganda: an analysis of three randomised controlled trials. Lancet 2008, 372: 300–13.CrossRef Six Week Extended-Dose Nevirapine (SWEN) Study Team: Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India, and Uganda: an analysis of three randomised controlled trials. Lancet 2008, 372: 300–13.CrossRef
10.
go back to reference Kumwenda NI, Hoover DR, Mofenson LM, Thigpen M, Kafulafula G, Li Q, Mipando L, Nkanaunena K, Mebrahtu T, Bulterys M, Fowler MG, Taha TE: Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission. N Engl J Med 2008, 359: 119–29.CrossRefPubMed Kumwenda NI, Hoover DR, Mofenson LM, Thigpen M, Kafulafula G, Li Q, Mipando L, Nkanaunena K, Mebrahtu T, Bulterys M, Fowler MG, Taha TE: Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission. N Engl J Med 2008, 359: 119–29.CrossRefPubMed
11.
go back to reference Spensley A, Sripipatana T, Turner A, Hoblitzelle C, Robinson J, Wilfert CM: Preventing mother-to-child transmission of HIV in resource-limited settings: the Elizabeth Glaser Pediatric AIDS Foundation experience. Am J Public Health 2009, 99: 631–7.CrossRefPubMed Spensley A, Sripipatana T, Turner A, Hoblitzelle C, Robinson J, Wilfert CM: Preventing mother-to-child transmission of HIV in resource-limited settings: the Elizabeth Glaser Pediatric AIDS Foundation experience. Am J Public Health 2009, 99: 631–7.CrossRefPubMed
12.
go back to reference Welty TK, Bulterys M, Welty ER, Tih PM, Ndikintum G, Nkuoh G, Nkfusai J, Kayita J, Nkengasong JN, Wilfert CM: Integrating prevention of mother-to-child HIV transmission into routine antenatal care: the key to program expansion in Cameroon. J Acquir Immun Defic Syndr 2005, 40: 486–93.CrossRef Welty TK, Bulterys M, Welty ER, Tih PM, Ndikintum G, Nkuoh G, Nkfusai J, Kayita J, Nkengasong JN, Wilfert CM: Integrating prevention of mother-to-child HIV transmission into routine antenatal care: the key to program expansion in Cameroon. J Acquir Immun Defic Syndr 2005, 40: 486–93.CrossRef
13.
go back to reference Kagaayi J, Dreyfuss ML, Kigozi G, Chen MZ, Wabwire-Mangen F, Serwadda D, Wawer MJ, Sewankambo N, Nalugoda F, Kiwanuka N, Kiddugavu M, Gray RH: Maternal self-medication and provision of nevirapine to newborns by women in Rakai, Uganda. J Acquir Immun Defic Syndr 2005, 39: 121–4.CrossRef Kagaayi J, Dreyfuss ML, Kigozi G, Chen MZ, Wabwire-Mangen F, Serwadda D, Wawer MJ, Sewankambo N, Nalugoda F, Kiwanuka N, Kiddugavu M, Gray RH: Maternal self-medication and provision of nevirapine to newborns by women in Rakai, Uganda. J Acquir Immun Defic Syndr 2005, 39: 121–4.CrossRef
14.
go back to reference Stringer JS, Sinkala M, Maclean CC, Levy J, Kankasa C, Degroot A, Stringer EM, Acosta EP, Goldenberg RL, Vermund SH: Effectiveness of a city-wide program to prevent mother-to-child HIV transmission in Lusaka, Zambia. AIDS 2005, 19: 1309–15.CrossRefPubMed Stringer JS, Sinkala M, Maclean CC, Levy J, Kankasa C, Degroot A, Stringer EM, Acosta EP, Goldenberg RL, Vermund SH: Effectiveness of a city-wide program to prevent mother-to-child HIV transmission in Lusaka, Zambia. AIDS 2005, 19: 1309–15.CrossRefPubMed
15.
go back to reference Stringer JS, Sinkala M, Goldenberg R, Vermund S, Acosta E: Monitoring nevirapine-based programmes for prevention of mother-to-child transmission of HIV-1. Lancet 2003, 362: 667.CrossRefPubMed Stringer JS, Sinkala M, Goldenberg R, Vermund S, Acosta E: Monitoring nevirapine-based programmes for prevention of mother-to-child transmission of HIV-1. Lancet 2003, 362: 667.CrossRefPubMed
16.
go back to reference World Health Organization: Towards universal access: scaling up priority HIV/AIDS interventions in the health sector: Progress report 2009. WHO, Geneva; 2009. World Health Organization: Towards universal access: scaling up priority HIV/AIDS interventions in the health sector: Progress report 2009. WHO, Geneva; 2009.
17.
go back to reference Chopra M, Rollins N: Infant feeding in the time of HIV: rapid assessment of infant feeding policy and programmes in four African countries scaling up prevention of mother to child transmission programmes. Arch Dis Child 2008, 93: 288–91.CrossRefPubMed Chopra M, Rollins N: Infant feeding in the time of HIV: rapid assessment of infant feeding policy and programmes in four African countries scaling up prevention of mother to child transmission programmes. Arch Dis Child 2008, 93: 288–91.CrossRefPubMed
18.
go back to reference Lazarus R, Struthers H, Violari A: Hopes, fears, knowledge and misunderstandings: responses of HIV-positive mothers to early knowledge of the status of their baby. AIDS Care 2009, 21: 329–34.CrossRefPubMed Lazarus R, Struthers H, Violari A: Hopes, fears, knowledge and misunderstandings: responses of HIV-positive mothers to early knowledge of the status of their baby. AIDS Care 2009, 21: 329–34.CrossRefPubMed
19.
go back to reference De Cock KM, Fowler MG, Mercier E, de Vincenzi I, Saba J, Hoff E, Alnwick DJ, Rogers M, Shaffer N: Prevention of mother-to-child HIV transmission in resource-poor countries: translating research into policy and practice. JAMA 2000, 283: 1175–82.CrossRefPubMed De Cock KM, Fowler MG, Mercier E, de Vincenzi I, Saba J, Hoff E, Alnwick DJ, Rogers M, Shaffer N: Prevention of mother-to-child HIV transmission in resource-poor countries: translating research into policy and practice. JAMA 2000, 283: 1175–82.CrossRefPubMed
20.
go back to reference Dunn DT, Newell ML, Ades AE, Peckham CS: Risk of human immunodeficiency virus type 1 transmission through breastfeeding. Lancet 1992, 340: 585–8.CrossRefPubMed Dunn DT, Newell ML, Ades AE, Peckham CS: Risk of human immunodeficiency virus type 1 transmission through breastfeeding. Lancet 1992, 340: 585–8.CrossRefPubMed
21.
go back to reference Nduati R, John G, Mbori-Ngacha D, Richardson B, Overbaugh J, Mwatha A, Ndinya-Achola J, Bwayo J, Onyango F, Hughes J, Kreiss J: Effect of breastfeeding and formula feeding on transmission of HIV-1: A randomized clinical trial. JAMA 2000, 283: 1167–74.CrossRefPubMed Nduati R, John G, Mbori-Ngacha D, Richardson B, Overbaugh J, Mwatha A, Ndinya-Achola J, Bwayo J, Onyango F, Hughes J, Kreiss J: Effect of breastfeeding and formula feeding on transmission of HIV-1: A randomized clinical trial. JAMA 2000, 283: 1167–74.CrossRefPubMed
22.
go back to reference Breastfeeding and HIV International Transmission Study Group: Late postnatal transmission of HIV-1 in breast-fed children: an individual patient data meta-analysis. J Infect Dis 2004, 189: 2154–66.CrossRef Breastfeeding and HIV International Transmission Study Group: Late postnatal transmission of HIV-1 in breast-fed children: an individual patient data meta-analysis. J Infect Dis 2004, 189: 2154–66.CrossRef
23.
go back to reference Rousseau CM, Nduati RW, Richardson BA, Steele MS, John-Stewart GC, Mbori-Ngacha DA, Kreiss JK, Overbaugh J: Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease. J Infect Dis 2003, 187: 741–7.CrossRefPubMed Rousseau CM, Nduati RW, Richardson BA, Steele MS, John-Stewart GC, Mbori-Ngacha DA, Kreiss JK, Overbaugh J: Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease. J Infect Dis 2003, 187: 741–7.CrossRefPubMed
24.
go back to reference Coutsoudis A, Pillay K, Spooner E, Kuhn L, Coovadia HM: Influence of infant feeding patterns on early mother-to-child transmission of HIV-1 in Durban, South Africa. Lancet 1999, 354: 471–6.CrossRefPubMed Coutsoudis A, Pillay K, Spooner E, Kuhn L, Coovadia HM: Influence of infant feeding patterns on early mother-to-child transmission of HIV-1 in Durban, South Africa. Lancet 1999, 354: 471–6.CrossRefPubMed
25.
go back to reference Farquhar C, John-Stewart G: The role of infant immune responses and genetic factors in preventing HIV-1 acquisition and disease progression. Clin Exp Immunol 2003, 134: 367–77.CrossRefPubMed Farquhar C, John-Stewart G: The role of infant immune responses and genetic factors in preventing HIV-1 acquisition and disease progression. Clin Exp Immunol 2003, 134: 367–77.CrossRefPubMed
26.
go back to reference Kuhn L, Meddows-Taylor S, Gray G, Tiemessen C: Human immunodeficiency virus (HIV)-specific cellular immune responses in newborns exposed to HIV in utero. Clin Infect Dis 2002, 34: 267–76.CrossRefPubMed Kuhn L, Meddows-Taylor S, Gray G, Tiemessen C: Human immunodeficiency virus (HIV)-specific cellular immune responses in newborns exposed to HIV in utero. Clin Infect Dis 2002, 34: 267–76.CrossRefPubMed
27.
go back to reference Chung MH, Kiarie JN, Richardson BA, Lehman DA, Overbaugh J, John-Stewart GC: Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing HIVNET 012 nevirapine versus short-course zidovudine. AIDS 2005, 19: 1415–22.CrossRefPubMed Chung MH, Kiarie JN, Richardson BA, Lehman DA, Overbaugh J, John-Stewart GC: Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing HIVNET 012 nevirapine versus short-course zidovudine. AIDS 2005, 19: 1415–22.CrossRefPubMed
28.
go back to reference Coutsoudis A, Pillay K, Kuhn L, Spooner E, Tsai WY, Coovadia HM: Method of feeding and transmission of HIV-1 from mothers to children by 15 months of age: prospective cohort study from Durban, South Africa. AIDS 2001, 15: 379–87.CrossRefPubMed Coutsoudis A, Pillay K, Kuhn L, Spooner E, Tsai WY, Coovadia HM: Method of feeding and transmission of HIV-1 from mothers to children by 15 months of age: prospective cohort study from Durban, South Africa. AIDS 2001, 15: 379–87.CrossRefPubMed
29.
go back to reference Iliff P, Piwoz E, Tavengwa N, Zunguza C, Marinda E, Nathoo K, Moulton L, Ward B, Humphrey J: Early exclusive breastfeeding reduces the risk of postnatal HIV-1 transmission and increases HIV-free survival. AIDS 2005, 19: 699–708.CrossRefPubMed Iliff P, Piwoz E, Tavengwa N, Zunguza C, Marinda E, Nathoo K, Moulton L, Ward B, Humphrey J: Early exclusive breastfeeding reduces the risk of postnatal HIV-1 transmission and increases HIV-free survival. AIDS 2005, 19: 699–708.CrossRefPubMed
30.
go back to reference Kuhn L, Sinkala M, Kankasa C, Semrau K, Kasonde P, Scott N, Mwiya M, Vwalika C, Walter J, Tsai WY, Aldrovandi G, Thea DM: High Uptake of Exclusive Breastfeeding and Reduced Early Post-natal HIV Transmission. PLOS ONE 2007, 2 (12) : -e1363. doi: 10.1371/journal.pone.0001363 CrossRefPubMed Kuhn L, Sinkala M, Kankasa C, Semrau K, Kasonde P, Scott N, Mwiya M, Vwalika C, Walter J, Tsai WY, Aldrovandi G, Thea DM: High Uptake of Exclusive Breastfeeding and Reduced Early Post-natal HIV Transmission. PLOS ONE 2007, 2 (12) : -e1363. doi: 10.​1371/​journal.​pone.​0001363 CrossRefPubMed
31.
go back to reference Coovadia HM, Rollins NC, Bland RM, Little K, Coutsoudis A, Bennish ML, Newell ML: Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study. Lancet 2007, 369: 1107–16.CrossRefPubMed Coovadia HM, Rollins NC, Bland RM, Little K, Coutsoudis A, Bennish ML, Newell ML: Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study. Lancet 2007, 369: 1107–16.CrossRefPubMed
32.
go back to reference Becquet R, Ekouevi DK, Menan H, Amani-Bosse C, Bequet L, Viho I, Dabis F, Timite-Konan M, Leroy V: Early mixed feeding and breastfeeding beyond 6 months increase the risk of postnatal HIV transmission: ANRS 1201/1202 Ditrame Plus, Abidjan, Cote D'Ivore. Preventive Medicine 2008, 47: 27–33.CrossRefPubMed Becquet R, Ekouevi DK, Menan H, Amani-Bosse C, Bequet L, Viho I, Dabis F, Timite-Konan M, Leroy V: Early mixed feeding and breastfeeding beyond 6 months increase the risk of postnatal HIV transmission: ANRS 1201/1202 Ditrame Plus, Abidjan, Cote D'Ivore. Preventive Medicine 2008, 47: 27–33.CrossRefPubMed
33.
go back to reference Smith MM, Kuhn L: Exclusive breast-feeding: Does it have the potential to reduce breast-feeding transmission of HIV-1? Nutrition Reviews 2000, 58: 333–40.CrossRefPubMed Smith MM, Kuhn L: Exclusive breast-feeding: Does it have the potential to reduce breast-feeding transmission of HIV-1? Nutrition Reviews 2000, 58: 333–40.CrossRefPubMed
34.
go back to reference Lawrence R, Lawrence R: Breastfeeding: A guide for the medical professional. St Louis, Missouri: Mosby, Inc; 1999. Lawrence R, Lawrence R: Breastfeeding: A guide for the medical professional. St Louis, Missouri: Mosby, Inc; 1999.
35.
go back to reference Thomas T, Masaba R, Ndivo R, Zeh C, Borkowf C, Thigpen M, DeCock K, Amornkul P, Greenberg A, Fowler M, Kisumu Breasfeeding Study Team: Prevention of Mother-to-Child Transmission of HIV-1 among Breastfeeding Mothers Using HAART: The Kisumu Breastfeeding Study, Kisumu, Kenya, 2003–2007. 15th Conference of Retrovirus and Opportunistic Infections Boston, USA Feb 2008 2008. Abstract 45aLB Thomas T, Masaba R, Ndivo R, Zeh C, Borkowf C, Thigpen M, DeCock K, Amornkul P, Greenberg A, Fowler M, Kisumu Breasfeeding Study Team: Prevention of Mother-to-Child Transmission of HIV-1 among Breastfeeding Mothers Using HAART: The Kisumu Breastfeeding Study, Kisumu, Kenya, 2003–2007. 15th Conference of Retrovirus and Opportunistic Infections Boston, USA Feb 2008 2008. Abstract 45aLB
36.
go back to reference Kesho Bora Study Group: Triple-antiretroviral prophylaxis during pregnancy and breastfeeding compared to short-ARV prophylaxis to prevent mother-to-chil transmission of HIV-1: the Kesho Bora randomized controlled trial in five sites in Burkino Faso, Kenya and South Africa. Fifth International AIDS Society Conference on HIV Treatment, Pathogenesis and Prevention, Cape Town, abstract WeLBPeC01 2009. Kesho Bora Study Group: Triple-antiretroviral prophylaxis during pregnancy and breastfeeding compared to short-ARV prophylaxis to prevent mother-to-chil transmission of HIV-1: the Kesho Bora randomized controlled trial in five sites in Burkino Faso, Kenya and South Africa. Fifth International AIDS Society Conference on HIV Treatment, Pathogenesis and Prevention, Cape Town, abstract WeLBPeC01 2009.
37.
go back to reference Kilewo C, Karlsson K, Ngarina M, Massawe A, Lyamuya E, Swai A, Lipyoga R, Mhalu F, Biberfeld G: Prevention of mother-to-child transmission of HIV-1 through breastfeeding by treating mothers with triple antiretroviral therapy in Dar es Salaam, Tanzania: the Mitra Plus study. J Acquir Immune Defic Syndr 2009, 52: 406–16.CrossRefPubMed Kilewo C, Karlsson K, Ngarina M, Massawe A, Lyamuya E, Swai A, Lipyoga R, Mhalu F, Biberfeld G: Prevention of mother-to-child transmission of HIV-1 through breastfeeding by treating mothers with triple antiretroviral therapy in Dar es Salaam, Tanzania: the Mitra Plus study. J Acquir Immune Defic Syndr 2009, 52: 406–16.CrossRefPubMed
38.
go back to reference Marazzi MC, Nielsen-Saines K, Buonomo E, Scarcella P, Germano P, Majid NA, Zimba I, Ceffa S, Palombi L: Increased infant human immunodeficiency virus-type one free survival at one year of age in sub-saharan Africa with maternal use of highly active antiretroviral therapy during breast-feeding. Pediatr Infect Dis J 2009, 28: 483–7.CrossRefPubMed Marazzi MC, Nielsen-Saines K, Buonomo E, Scarcella P, Germano P, Majid NA, Zimba I, Ceffa S, Palombi L: Increased infant human immunodeficiency virus-type one free survival at one year of age in sub-saharan Africa with maternal use of highly active antiretroviral therapy during breast-feeding. Pediatr Infect Dis J 2009, 28: 483–7.CrossRefPubMed
39.
go back to reference Peltier CA, Ndayisaba GF, Lepage P, van GJ, Leroy V, Pharm CO, Ndimubanzi PC, Courteille O, Arendt V: Breastfeeding with maternal antiretroviral therapy or formula feeding to prevent HIV postnatal mother-to-child transmission in Rwanda. AIDS 2009, 23: 2473–7.CrossRef Peltier CA, Ndayisaba GF, Lepage P, van GJ, Leroy V, Pharm CO, Ndimubanzi PC, Courteille O, Arendt V: Breastfeeding with maternal antiretroviral therapy or formula feeding to prevent HIV postnatal mother-to-child transmission in Rwanda. AIDS 2009, 23: 2473–7.CrossRef
40.
go back to reference Shapiro RL, Hughes M, Ogwu A: A randomized trial comparing highly active antiretroviral therapy regimens for virologic effiacy and the prevention of mother-to-child transmission among breastfeeding women in Botswana (The Mma Bana Study). 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention; WELBB 101: Cape Town-19–22 July 2009. Shapiro RL, Hughes M, Ogwu A: A randomized trial comparing highly active antiretroviral therapy regimens for virologic effiacy and the prevention of mother-to-child transmission among breastfeeding women in Botswana (The Mma Bana Study). 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention; WELBB 101: Cape Town-19–22 July 2009.
41.
go back to reference Myer L, Rabkin M, Abrams EJ, Rosenfield A, El Sadr W: Focus on women: linking HIV care and treatment with reproductive health services in the MTCT-Plus initiative. Reproductive Health Matters 2005, 13: 136–46.CrossRefPubMed Myer L, Rabkin M, Abrams EJ, Rosenfield A, El Sadr W: Focus on women: linking HIV care and treatment with reproductive health services in the MTCT-Plus initiative. Reproductive Health Matters 2005, 13: 136–46.CrossRefPubMed
42.
go back to reference Kuhn L, Aldrovandi GM, Sinkala M, Kankasa C, Semrau K, Mwiya M, Kasonde P, Scott N, Vwalika C, Walter J, Bulterys M, Tsai WY, Thea DM: Effects of early, abrupt cessation of breastfeeding on HIV-free survival of children in Zambia. N Engl J Med 2008, 359: 130–41.CrossRefPubMed Kuhn L, Aldrovandi GM, Sinkala M, Kankasa C, Semrau K, Mwiya M, Kasonde P, Scott N, Vwalika C, Walter J, Bulterys M, Tsai WY, Thea DM: Effects of early, abrupt cessation of breastfeeding on HIV-free survival of children in Zambia. N Engl J Med 2008, 359: 130–41.CrossRefPubMed
43.
go back to reference Chasela C, Hudgens M, Jamieson DJ: Both maternal HAART and daily infant nevirapine (NVP) are effective in reducing HIV-1 transmission during breastfeeding in a randomized trial in Malawi: 28 week results of the Breastfeeding, Antiretroviral and Nutrition (BAN) Study. 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention; WELBC 103: Cape Town-19–22 July 2009. Chasela C, Hudgens M, Jamieson DJ: Both maternal HAART and daily infant nevirapine (NVP) are effective in reducing HIV-1 transmission during breastfeeding in a randomized trial in Malawi: 28 week results of the Breastfeeding, Antiretroviral and Nutrition (BAN) Study. 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention; WELBC 103: Cape Town-19–22 July 2009.
44.
go back to reference Kagaayi J, Gray RH, Brahmbhatt H, Kigozi G, Nalugoda F, Wabwire-Mangen F, Serwadda D, Sewankambo N, Ddungu V, Ssebagala D, Sekasanvu J, Kigozi G, Makumbi F, Kiwanuka N, Lutalo T, Reynolds SJ, Wawer MJ: Survival of infants born to HIV-positive mothers by feeding modality in Rakai, Uganda. PLOS ONE 2008, 3: e3877.CrossRefPubMed Kagaayi J, Gray RH, Brahmbhatt H, Kigozi G, Nalugoda F, Wabwire-Mangen F, Serwadda D, Sewankambo N, Ddungu V, Ssebagala D, Sekasanvu J, Kigozi G, Makumbi F, Kiwanuka N, Lutalo T, Reynolds SJ, Wawer MJ: Survival of infants born to HIV-positive mothers by feeding modality in Rakai, Uganda. PLOS ONE 2008, 3: e3877.CrossRefPubMed
45.
go back to reference Thior I, Lockman S, Smeaton LM, Shapiro RL, Wester C, Heymann SJ, Gilbert PB, Stevens L, Peter T, Kim S, van Widenfelt E, Moffat C, Ndase P, Arimi P, Kebaabetswe P, Mazonde P, Makhema J, McIntosh K, Novitsky V, Lee TH, Marlink R, Lagakos S, Essex M, Mashi Study Team: Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study. JAMA 2006, 296: 794–805.CrossRefPubMed Thior I, Lockman S, Smeaton LM, Shapiro RL, Wester C, Heymann SJ, Gilbert PB, Stevens L, Peter T, Kim S, van Widenfelt E, Moffat C, Ndase P, Arimi P, Kebaabetswe P, Mazonde P, Makhema J, McIntosh K, Novitsky V, Lee TH, Marlink R, Lagakos S, Essex M, Mashi Study Team: Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study. JAMA 2006, 296: 794–805.CrossRefPubMed
46.
go back to reference Jelliffe DB, Jelliffe EF: Human milk in the modern world. New York: Oxford University Press; 1978. Jelliffe DB, Jelliffe EF: Human milk in the modern world. New York: Oxford University Press; 1978.
47.
go back to reference Kuhn L, Aldrovandi GM, Sinkala M, Kankasa C, Semrau K, Kasonde P, Mwiya M, Tsai WY, Thea DM: Differential effects of early weaning for HIV-free survival of children born to HIV-infected mothers by severity of maternal disease. PLOS ONE 2009, 4: e6059.CrossRefPubMed Kuhn L, Aldrovandi GM, Sinkala M, Kankasa C, Semrau K, Kasonde P, Mwiya M, Tsai WY, Thea DM: Differential effects of early weaning for HIV-free survival of children born to HIV-infected mothers by severity of maternal disease. PLOS ONE 2009, 4: e6059.CrossRefPubMed
48.
go back to reference Filteau S: The HIV-exposed, uninfected African child. Tropical Medicine & International Health 2009, 14: 1–12.CrossRef Filteau S: The HIV-exposed, uninfected African child. Tropical Medicine & International Health 2009, 14: 1–12.CrossRef
49.
go back to reference Kuhn L, Thea DM, Aldrovandi GM: Bystander effects: children who escape infection but not harm. Journal of Acquired Immune Deficiency Syndromes 2007, 46: 517–8.CrossRefPubMed Kuhn L, Thea DM, Aldrovandi GM: Bystander effects: children who escape infection but not harm. Journal of Acquired Immune Deficiency Syndromes 2007, 46: 517–8.CrossRefPubMed
Metadata
Title
HIV prevention is not enough: child survival in the context of prevention of mother to child HIV transmission
Authors
Louise Kuhn
Moses Sinkala
Don M Thea
Chipepo Kankasa
Grace M Aldrovandi
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Journal of the International AIDS Society / Issue 1/2009
Electronic ISSN: 1758-2652
DOI
https://doi.org/10.1186/1758-2652-12-36

Other articles of this Issue 1/2009

Journal of the International AIDS Society 1/2009 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.