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AIDS Research and Therapy
Published in: AIDS Research and Therapy 1/2014

Open Access 01-12-2014 | Case report

HIV post exposure prophylaxis induced bicytopenia: a case report

Authors: Benjamin T Schleenvoigt, John P Fobiwe, Peter M Keller, Stefan Hagel, Mathias W Pletz

Published in: AIDS Research and Therapy | Issue 1/2014

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Abstract

Long and short term side effects of antiretroviral drugs are not fully understood yet. Here a case of reversible blood count changes following post exposure prophylaxis with tenofovir/emtricitabin and lopinavir/ritonavir is reported. We propose that antiretroviral drugs used in post exposure prophylaxis may have a significant impact on hematopoiesis.
Literature
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Gemeinsame Erklarung der Deutschen A-G : Post-exposure prophylaxis of HIV infection. German-Austrian recommendations, update September 2007. Dtsch Med Wochenschr. 2009, 134 (Suppl 1): S16-33.
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Choi SY, Kim I, Kim NJ, Lee SA, Choi YA, Bae JY, Kwon JH, Choe PG, Park WB, Yoon SS: Hematological manifestations of human immunodeficiency virus infection and the effect of highly active anti-retroviral therapy on cytopenia. Korean J Hematol. 2011, 46: 253-257. 10.5045/kjh.2011.46.4.253PubMedCentralCrossRefPubMed
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Alp E, Bozkurt I, Doganay M: Epidemiological and clinical characteristics of HIV/AIDS patients followed-up in Cappadocia region: 18 years experience. Mikrobiyol Bul. 2011, 45: 125-136.PubMed
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Colebunders R, De Schacht C, Vanwolleghem T, Callens S: Lopinavir/ritonavir- and indinavir-induced thrombocytopenia in a patient with HIV infection. Int J Infect Dis. 2004, 8: 315-316. 10.1016/j.ijid.2004.05.001CrossRefPubMed
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Fellay J, Boubaker K, Ledergerber B, Bernasconi E, Furrer H, Battegay M, Hirschel B, Vernazza P, Francioli P, Greub G: Prevalence of adverse events associated with potent antiretroviral treatment: swiss HIV cohort study. Lancet. 2001, 358: 1322-1327. 10.1016/S0140-6736(01)06413-3CrossRefPubMed
Metadata
Title
HIV post exposure prophylaxis induced bicytopenia: a case report
Authors
Benjamin T Schleenvoigt
John P Fobiwe
Peter M Keller
Stefan Hagel
Mathias W Pletz
Publication date
01-12-2014
Publisher
BioMed Central
Published in
AIDS Research and Therapy / Issue 1/2014
Electronic ISSN: 1742-6405
DOI
https://doi.org/10.1186/1742-6405-11-11

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