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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 4/2010

Open Access 01-12-2010 | Oral presentation

HIV entry blocked by maraviroc can cause an overestimation of viral load

Authors: RD Sloan, BD Kuhl, VG Kramer, DA Donahue, T Bar-Magen, R Tressler, MA Wainberg

Published in: Journal of the International AIDS Society | Special Issue 4/2010

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Excerpt

As a chemokine coreceptor antagonist, maraviroc (MVC) inhibits HIV infection by preventing viral entry into the host cell. As this effect is extracellular, we hypothesized that virus might be returned to plasma upon antagonism of CCR5 by MVC and that this thereby influences measurement of plasma viral load by qRT-PCR, in contrast to other drug classes that act intracellularly. …
Metadata
Title
HIV entry blocked by maraviroc can cause an overestimation of viral load
Authors
RD Sloan
BD Kuhl
VG Kramer
DA Donahue
T Bar-Magen
R Tressler
MA Wainberg
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S4-O46

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