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Published in: AIDS Research and Therapy 1/2019

Open Access 01-12-2019 | HIV Drug | Short Report

High rates of transmitted NNRTI resistance among persons with acute HIV infection in Malawi: implications for first-line dolutegravir scale-up

Authors: Sarah E. Rutstein, Jane S. Chen, Julie A. E. Nelson, Samuel Phiri, William C. Miller, Mina C. Hosseinipour

Published in: AIDS Research and Therapy | Issue 1/2019

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Abstract

High rates of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was a key consideration in the WHO policies transitioning first-line regimens to include integrase inhibitors (dolutegravir [DTG]). However, recent data suggests a relationship between DTG and neural tube defects among women exposed during conception, giving providers and policymakers pause regarding the planned regimen changes. We examined HIV drug resistance among a cohort of 46 acutely infected persons in Malawi. Our data demonstrates high levels of transmitted resistance, 11% using standard resistance surveillance mutations and 20% when additional NNRTI polymorphisms that may affect treatment response are included. High resistance rates in this treatment-naïve patient population reinforces the critical nature of DTG-based options in the context of public-health driven treatment programs.
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Metadata
Title
High rates of transmitted NNRTI resistance among persons with acute HIV infection in Malawi: implications for first-line dolutegravir scale-up
Authors
Sarah E. Rutstein
Jane S. Chen
Julie A. E. Nelson
Samuel Phiri
William C. Miller
Mina C. Hosseinipour
Publication date
01-12-2019
Publisher
BioMed Central
Published in
AIDS Research and Therapy / Issue 1/2019
Electronic ISSN: 1742-6405
DOI
https://doi.org/10.1186/s12981-019-0220-8

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