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01-12-2011 | Research

Histopathological Safety Evaluation of Newly-Developed MgO Sealer

Authors: K Nakano, M Tomida, M Sato, S Matsuura, A Yamamoto, E Kasahara, T Kawakami

Published in: European Journal of Medical Research | Issue 12/2011

Abstract

We aimed to evaluate the subcutaneous tissue reaction to a newly-developed MgO Sealer for root canals. We injected the experimental material and three existing control materials into the dorsal area of 43 male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding sites was removed and histopathological examination was performed. The results demonstrate that the basic histopathological reaction is the formation of fibrous capsules consisting of granulation tissue around the experimental and control embedded materials. Based on our results, we believe that the newly-developed MgO Sealer is as safe as the existing control materials and can be considered for dental use as a root canal sealer.

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Title: Histopathological Safety Evaluation of Newly-Developed MgO Sealer
Authors: K Nakano
M Tomida
M Sato
S Matsuura
A Yamamoto
E Kasahara
T Kawakami
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 12/2011
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/2047-783X-16-12-526

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Histopathological Safety Evaluation of Newly-Developed MgO Sealer

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