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World Journal of Surgery
Published in: World Journal of Surgery 10/2014

01-10-2014

High Survival in Patients Operated for Small Isolated Liver Metastases from Gastric Cancer: A Multi-institutional Study

Authors: Koji Komeda, Michihiro Hayashi, Shoji Kubo, Hiroaki Nagano, Takuya Nakai, Masaki Kaibori, Hiroshi Wada, Shigekazu Takemura, Masahiko Kinoshita, Chikato Koga, Masataka Matsumoto, Tatsuma Sakaguchi, Yoshihiro Inoue, Fumitoshi Hirokawa, A-Hon Kwon, Kazuhisa Uchiyama

Published in: World Journal of Surgery | Issue 10/2014

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Abstract

Background

Although several studies have reported the outcomes of surgery for the treatment of liver metastases of gastric cancer (GLM), indications for liver resection for gastric metastases remain controversial. This study was designed to identify prognostic determinants that identify operable hepatic metastases from gastric cancer and to evaluate the actual targets of surgical therapy.

Methods

Retrospective analysis was performed on outcomes for 24 consecutive patients at five institutions who underwent gastrectomy for gastric cancer followed by curative hepatectomy for GLM between 2000 and June 2012.

Results

Overall 5-year survival and median survival were 40.1 % and 22.3 months, respectively. Uni- and multivariate analyses showed that liver metastatic tumour size less than 5 cm was the most important predictor of overall survival (OS, p = 0.03). Four patients survived >5 years. Repeat hepatectomy was performed in three patients. Two of these patients have remained disease-free since the repeat hepatectomy.

Conclusions

GLM patients with metastatic tumour diameter less than 5 cm maximum are the best candidates for hepatectomy. Hepatic resection should be considered as an option for gastric cancer patients with liver metastases.
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Metadata
Title
High Survival in Patients Operated for Small Isolated Liver Metastases from Gastric Cancer: A Multi-institutional Study
Authors
Koji Komeda
Michihiro Hayashi
Shoji Kubo
Hiroaki Nagano
Takuya Nakai
Masaki Kaibori
Hiroshi Wada
Shigekazu Takemura
Masahiko Kinoshita
Chikato Koga
Masataka Matsumoto
Tatsuma Sakaguchi
Yoshihiro Inoue
Fumitoshi Hirokawa
A-Hon Kwon
Kazuhisa Uchiyama
Publication date
01-10-2014
Publisher
Springer US
Published in
World Journal of Surgery / Issue 10/2014
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-014-2608-x

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