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Tumor Biology
Published in: Tumor Biology 7/2014

01-07-2014 | Research Article

High serum transforming growth factor beta 1 (TGFB1) level predicts better survival in breast cancer

Authors: Rumeysa Ciftci, Faruk Tas, Ceren Tilgen Yasasever, Ece Aksit, Senem Karabulut, Fatma Sen, Serkan Keskin, Leyla Kilic, İbrahim Yildiz, Hamza Ugur Bozbey, Derya Duranyildiz, Sezai Vatansever

Published in: Tumor Biology | Issue 7/2014

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Abstract

The transforming growth factor beta 1 (TGFB1) is a regulatory cytokine with both tumor suppressor and tumor-promoting effects in breast cancer (BC) cell lines and tissue. Data about level of circulating TGFB1 and its prognostic significance in BC patients is conflicting. The objective of this study is to determine the clinical significance of the serum TGFB1 levels in BC patients. We enrolled 96 female patients with histopathologically diagnosed BC who did not receive chemotherapy (CT) or radiotherapy. Serum TGFB1 levels were measured by ELISA method and compared with 30 healthy controls. The mean serum TGFB1 level of BC patients was significantly higher than controls (0.08 vs. 0.04 ng/ml, p < 0.001). There was no significant difference according to known disease-related clinicopathological or laboratory parameters. Serum TGFB1 level had a significant impact on overall survival in both univariate (p = 0.01) and multivariate analysis (p = 0.013). Serum TGFB1 level is elevated in BC patients and has a favorable prognostic value. However, it has no predictive role on CT response.
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Metadata
Title
High serum transforming growth factor beta 1 (TGFB1) level predicts better survival in breast cancer
Authors
Rumeysa Ciftci
Faruk Tas
Ceren Tilgen Yasasever
Ece Aksit
Senem Karabulut
Fatma Sen
Serkan Keskin
Leyla Kilic
İbrahim Yildiz
Hamza Ugur Bozbey
Derya Duranyildiz
Sezai Vatansever
Publication date
01-07-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 7/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-014-1932-y

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