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Open Access 01-12-2016 | Original Article

High prevalence of secondary factors for bone fragility in patients with a recent fracture independently of BMD

Authors: F. Malgo, N. M. Appelman-Dijkstra, M. F. Termaat, H. J. L. van der Heide, I. B. Schipper, T. J. Rabelink, N. A. T. Hamdy

Published in: Archives of Osteoporosis | Issue 1/2016

Abstract

Summary

In this study, we demonstrate a high prevalence of secondary factors in patients with a recent fracture independently of bone mineral density (BMD). Our results suggest that patients with a recent fracture should be screened for secondary factors for bone fragility regardless of BMD values.

Introduction

Secondary factors for bone fragility are common in patients with osteoporosis who have sustained a fracture. The majority of fragility fractures occurs, however, in patients with osteopenia, and it is not known whether secondary factors may contribute to fracture risk in these patients or in those with normal BMD.

Methods

Prospective cohort study evaluating the prevalence of secondary factors for bone fragility in consecutive patients referred to our fracture liaison service from June 2012 to June 2014 after a recent fracture.

Results

Seven hundred nine patients were included, 201 (28 %) with osteoporosis, 391 (55 %) with osteopenia and 117 (17 %) with normal BMD. Mean age was 66.0 ± 9.8 years, 504 (73 %) were women and 390 (57 %) had one or more underlying secondary factor. Evaluation of clinical risk factors using fracture risk assessment tool (FRAX) identified 38 % of patients with ≥1 secondary factor including smoking (18 %), excessive alcohol use (12 %), glucocorticoid use (12 %) and rheumatoid arthritis (3 %). Laboratory investigations revealed chronic kidney disease in 13 %, monoclonal gammopathy also in 13 % and primary or secondary hyperparathyroidism in 1 and 6 %, respectively. Secondary factors for bone fragility were equally prevalent in patients with osteoporosis, osteopenia or normal BMD.

Conclusions

Our findings demonstrate a high prevalence of secondary factors for bone fragility in patients who have sustained a recent fracture, independently of BMD. The significant number of documented factors, which were treatable, suggest that patients who sustained a fracture should be screened for secondary factors for bone fragility regardless of BMD values to optimise secondary fracture prevention.

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Title: High prevalence of secondary factors for bone fragility in patients with a recent fracture independently of BMD
Authors: F. Malgo
N. M. Appelman-Dijkstra
M. F. Termaat
H. J. L. van der Heide
I. B. Schipper
T. J. Rabelink
N. A. T. Hamdy
Publication date: 01-12-2016
Publisher: Springer London
Published in: Archives of Osteoporosis / Issue 1/2016
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-016-0258-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

High prevalence of secondary factors for bone fragility in patients with a recent fracture independently of BMD

Abstract

Summary

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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