Published in:
Open Access
01-12-2010 | Poster presentation
High levels of polymorphisms related to raltegravir resistance among raltegravir-naïve individuals in Brazil
Authors:
N Mantovani Pena, R Gonçalves Azevedo, D Funayama Castro, R Sobhie Diaz, S Vasconcelos Komninakis
Published in:
Journal of the International AIDS Society
|
Special Issue 4/2010
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Excerpt
Raltegravir (RAL) is an HIV-1 integrase strand-transfer inhibitor that has exhibited substantial efficacy and a favorable safety profile in HIV-1 infected patients. The goal of this study was to explore the presence of natural polymorphisms and primary mutations related to RAL resistance among HIV-1 patients failing to multiple antiretroviral agents. …