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Published in: Diagnostic Pathology 1/2011

Open Access 01-12-2011 | Case Report

High grade angiosarcoma arising in fibroadenoma

Authors: Emina Babarović, Gordana Zamolo, Elvira Mustać, Miroslav Strčić

Published in: Diagnostic Pathology | Issue 1/2011

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Abstract

Primary angiosarcoma of the breast is a rare tumour that account for fewer than 0.05% of all malignant mammary tumours. Angiosarcoma may have an perfidious clinical onset. Radiologic findings are often nonspecific and may appear completely normal in one-third of cases with primary angiosarcoma. The prognosis is usually poor because of the high rates of local recurrence and early development of metastases. Aggressive surgical resection is the mainstay of treatment. The role of adjuvant therapy has not yet been well established.
Here we present a case of a 53 year old, postmenopausal women with primary angiosarcoma arising in fibroadenoma. To our knowledge, this is the first case described in the literature to date.

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Literature
1.
go back to reference Olawaiye AB, Morgan JA, Goodman A, Fuller AF, Penson RT: Epithelioid angiosarcoma of the uterus: a review of management. Arch Gynecol Obstet. 2008, 278: 401-4. 10.1007/s00404-008-0727-z.CrossRefPubMed Olawaiye AB, Morgan JA, Goodman A, Fuller AF, Penson RT: Epithelioid angiosarcoma of the uterus: a review of management. Arch Gynecol Obstet. 2008, 278: 401-4. 10.1007/s00404-008-0727-z.CrossRefPubMed
2.
go back to reference Bösmüller H, Gruber C, Haitchi-Petnehazy S, Wagner D, Webersinke G, Hauptmann S: Primary angiosarcoma of the ovary with prominent fibrosis of the ovarian stroma. Case report of an 81-year old patient. Diagn Pathol. 2011, 6: 65-10.1186/1746-1596-6-65.PubMedCentralCrossRefPubMed Bösmüller H, Gruber C, Haitchi-Petnehazy S, Wagner D, Webersinke G, Hauptmann S: Primary angiosarcoma of the ovary with prominent fibrosis of the ovarian stroma. Case report of an 81-year old patient. Diagn Pathol. 2011, 6: 65-10.1186/1746-1596-6-65.PubMedCentralCrossRefPubMed
3.
go back to reference Al Ali J, Ko HH, Owen D, Steinbrecher UP: Epithelioid angiosarcoma of the small bowel. Gastrointest Endosc. 2006, 64: 1018-21. 10.1016/j.gie.2006.04.020.CrossRefPubMed Al Ali J, Ko HH, Owen D, Steinbrecher UP: Epithelioid angiosarcoma of the small bowel. Gastrointest Endosc. 2006, 64: 1018-21. 10.1016/j.gie.2006.04.020.CrossRefPubMed
4.
go back to reference Pandit SA, Fiedler PN, Westcott JL: Primary angiosarcoma of the lung. Ann Diagn Pathol. 2005, 9: 302-4. 10.1016/j.anndiagpath.2005.04.001.CrossRefPubMed Pandit SA, Fiedler PN, Westcott JL: Primary angiosarcoma of the lung. Ann Diagn Pathol. 2005, 9: 302-4. 10.1016/j.anndiagpath.2005.04.001.CrossRefPubMed
5.
go back to reference Uto T, Bando M, Yamauchi H, Nakayama M, Ohata M, Mato N, Nakaya T, Yamasawa H, Kawai T, Sugiyama Y: Primary cardiac angiosarcoma of the right auricle with difficult-to-treat bilateral pleural effusion. Intern Med. 2011, 50: 2371-4. 10.2169/internalmedicine.50.5751.CrossRefPubMed Uto T, Bando M, Yamauchi H, Nakayama M, Ohata M, Mato N, Nakaya T, Yamasawa H, Kawai T, Sugiyama Y: Primary cardiac angiosarcoma of the right auricle with difficult-to-treat bilateral pleural effusion. Intern Med. 2011, 50: 2371-4. 10.2169/internalmedicine.50.5751.CrossRefPubMed
7.
go back to reference Siddens JD, Fishman JR, Jackson IT, Nesi FA, Tsao K: Primary orbital angiosarcoma: a case report. Ophthal Plast Reconstr Surg. 1999, 15: 454-9. 10.1097/00002341-199911000-00019.CrossRefPubMed Siddens JD, Fishman JR, Jackson IT, Nesi FA, Tsao K: Primary orbital angiosarcoma: a case report. Ophthal Plast Reconstr Surg. 1999, 15: 454-9. 10.1097/00002341-199911000-00019.CrossRefPubMed
8.
go back to reference Isa NM, James DT, Saw TH, Pennisi R, Gough I: Primary angiosarcoma of the thyroid gland with recurrence diagnosed by fine needle aspiration: a case report. Diagn Cytopathol. 2009, 37: 427-32. 10.1002/dc.21065.CrossRefPubMed Isa NM, James DT, Saw TH, Pennisi R, Gough I: Primary angiosarcoma of the thyroid gland with recurrence diagnosed by fine needle aspiration: a case report. Diagn Cytopathol. 2009, 37: 427-32. 10.1002/dc.21065.CrossRefPubMed
9.
go back to reference Luini A, Gatti G, Diaz J, Botteri E, Oliveira E, Cecilio Sahium de Almeida R, Veronesi P, Intra M, Pagani G, Naninato P, Viale G: Angiosarcoma of the breast: the experience of the European Institute of Oncology and a review of the literature. Breast Cancer Res Treat. 2007, 105: 81-5. 10.1007/s10549-006-9429-z.CrossRefPubMed Luini A, Gatti G, Diaz J, Botteri E, Oliveira E, Cecilio Sahium de Almeida R, Veronesi P, Intra M, Pagani G, Naninato P, Viale G: Angiosarcoma of the breast: the experience of the European Institute of Oncology and a review of the literature. Breast Cancer Res Treat. 2007, 105: 81-5. 10.1007/s10549-006-9429-z.CrossRefPubMed
10.
go back to reference Biswas T, Tang P, Muhs A, Ling M: Angiosarcoma of the breast: a rare clinicopathological entity. Am J Clin Oncol. 2009, 32: 582-6. 10.1097/COC.0b013e3181967f09.CrossRefPubMed Biswas T, Tang P, Muhs A, Ling M: Angiosarcoma of the breast: a rare clinicopathological entity. Am J Clin Oncol. 2009, 32: 582-6. 10.1097/COC.0b013e3181967f09.CrossRefPubMed
11.
go back to reference Zhou SA, Wei H, Ding K: A Rare Case of Metachronous Bilateral Angiosarcoma of the Breast. Breast Care (Basel). 2009, 4: 405-407. 10.1159/000261506.CrossRef Zhou SA, Wei H, Ding K: A Rare Case of Metachronous Bilateral Angiosarcoma of the Breast. Breast Care (Basel). 2009, 4: 405-407. 10.1159/000261506.CrossRef
12.
go back to reference Ryan JF, Kealy WF: Concomitant angiosarcoma and carcinoma of the breast: a case report. Histopathology. 1985, 9: 893-9. 10.1111/j.1365-2559.1985.tb02874.x.CrossRefPubMed Ryan JF, Kealy WF: Concomitant angiosarcoma and carcinoma of the breast: a case report. Histopathology. 1985, 9: 893-9. 10.1111/j.1365-2559.1985.tb02874.x.CrossRefPubMed
13.
go back to reference Tranbaloc P, Lefranc JP, Blondon J, Chomette G: Angiosarcoma of the breast associated with contralateral carcinoma. Apropos of a case report. Ann Pathol. 1988, 8: 67-9.PubMed Tranbaloc P, Lefranc JP, Blondon J, Chomette G: Angiosarcoma of the breast associated with contralateral carcinoma. Apropos of a case report. Ann Pathol. 1988, 8: 67-9.PubMed
14.
go back to reference Takenaka M, Tanaka M, Isobe M, Yamaguchi R, Kojiro M, Shirouzu K: Angiosarcoma of the breast with silicone granuloma: a case report. Kurume Med J. 2009, 56: 33-7. 10.2739/kurumemedj.56.33.CrossRefPubMed Takenaka M, Tanaka M, Isobe M, Yamaguchi R, Kojiro M, Shirouzu K: Angiosarcoma of the breast with silicone granuloma: a case report. Kurume Med J. 2009, 56: 33-7. 10.2739/kurumemedj.56.33.CrossRefPubMed
15.
go back to reference Diaz NM, Palmer JO, McDivitt RW: Carcinoma arising within fibroadenomas of the breast. A clinicopathologic study of 105 patients. Am J Clin Pathol. 1991, 95: 614-22.PubMed Diaz NM, Palmer JO, McDivitt RW: Carcinoma arising within fibroadenomas of the breast. A clinicopathologic study of 105 patients. Am J Clin Pathol. 1991, 95: 614-22.PubMed
16.
go back to reference Mamoon N, Mushtaq S, Hassan U, Rashid R, Khadim MT, Sarfraz T, Waqar MA: Angiosarcoma arising in recurrent phyllodes tumour. Histopathology. 2009, 54: 913-6. 10.1111/j.1365-2559.2009.03314.x.CrossRefPubMed Mamoon N, Mushtaq S, Hassan U, Rashid R, Khadim MT, Sarfraz T, Waqar MA: Angiosarcoma arising in recurrent phyllodes tumour. Histopathology. 2009, 54: 913-6. 10.1111/j.1365-2559.2009.03314.x.CrossRefPubMed
17.
go back to reference Barrenetxea G, Schneider J, Tánago JG, Pérez C, Centeno MM, Rodríguez-Escudero FJ: Angiosarcoma of the breast and pregnancy: a new therapeutic approach. Eur J Obstet Gynecol Reprod Biol. 1995, 60: 87-9. 10.1016/0028-2243(95)80002-6.CrossRefPubMed Barrenetxea G, Schneider J, Tánago JG, Pérez C, Centeno MM, Rodríguez-Escudero FJ: Angiosarcoma of the breast and pregnancy: a new therapeutic approach. Eur J Obstet Gynecol Reprod Biol. 1995, 60: 87-9. 10.1016/0028-2243(95)80002-6.CrossRefPubMed
18.
go back to reference Chen KT, Kirkegaard DD, Bocian JJ: Angiosarcoma of the breast. Cancer. 1980, 46: 368-71. 10.1002/1097-0142(19800715)46:2<368::AID-CNCR2820460226>3.0.CO;2-E.CrossRefPubMed Chen KT, Kirkegaard DD, Bocian JJ: Angiosarcoma of the breast. Cancer. 1980, 46: 368-71. 10.1002/1097-0142(19800715)46:2<368::AID-CNCR2820460226>3.0.CO;2-E.CrossRefPubMed
19.
go back to reference Sher T, Hennessy BT, Valero V, Broglio K, Woodward WA, Trent J, Hunt KK, Hortobagyi GN, Gonzalez-Angulo AM: Primary angiosarcomas of the breast. Cancer. 2007, 110: 173-8. 10.1002/cncr.22784.PubMedCentralCrossRefPubMed Sher T, Hennessy BT, Valero V, Broglio K, Woodward WA, Trent J, Hunt KK, Hortobagyi GN, Gonzalez-Angulo AM: Primary angiosarcomas of the breast. Cancer. 2007, 110: 173-8. 10.1002/cncr.22784.PubMedCentralCrossRefPubMed
20.
go back to reference Liberman L, Dershaw DD, Kaufman RJ, Rosen PP: Angiosarcoma of the breast. Radiology. 1992, 183: 649-54.CrossRefPubMed Liberman L, Dershaw DD, Kaufman RJ, Rosen PP: Angiosarcoma of the breast. Radiology. 1992, 183: 649-54.CrossRefPubMed
21.
go back to reference Prescott RJ, Banerjee SS, Eyden BP, Haboubi NY: Cutaneous epithelioid angiosarcoma: a clinicopathological study of four cases. Histopathology. 1994, 25: 421-10.1111/j.1365-2559.1994.tb00003.x.CrossRefPubMed Prescott RJ, Banerjee SS, Eyden BP, Haboubi NY: Cutaneous epithelioid angiosarcoma: a clinicopathological study of four cases. Histopathology. 1994, 25: 421-10.1111/j.1365-2559.1994.tb00003.x.CrossRefPubMed
22.
go back to reference Nascimento AF, Raut CP, Fletcher CD: Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic. Am J Surg Pathol. 2008, 32: 1896-904. 10.1097/PAS.0b013e318176dbc7.CrossRefPubMed Nascimento AF, Raut CP, Fletcher CD: Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic. Am J Surg Pathol. 2008, 32: 1896-904. 10.1097/PAS.0b013e318176dbc7.CrossRefPubMed
23.
go back to reference Zelek L, Llombart-Cussac A, Terrier P, Pivot X, Guinebretiere JM, Le Pechoux C, Tursz T, Rochard F, Spielmann M, Le Cesne A: Prognostic factors in primary breast sarcomas: a series of patients with long-term follow-up. J Clin Oncol. 2003, 21: 2583-8. 10.1200/JCO.2003.06.080.CrossRefPubMed Zelek L, Llombart-Cussac A, Terrier P, Pivot X, Guinebretiere JM, Le Pechoux C, Tursz T, Rochard F, Spielmann M, Le Cesne A: Prognostic factors in primary breast sarcomas: a series of patients with long-term follow-up. J Clin Oncol. 2003, 21: 2583-8. 10.1200/JCO.2003.06.080.CrossRefPubMed
24.
go back to reference Bousquet G, Confavreux C, Magné N, de Lara CT, Poortmans P, Senkus E, de Lafontan B, Bolla M, Largillier R, Lagneau E, Kadish S, Lemanski C, Ozsahin M, Belkacémi Y: Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network. Radiother Oncol. 2007, 85: 355-61. 10.1016/j.radonc.2007.10.015.CrossRefPubMed Bousquet G, Confavreux C, Magné N, de Lara CT, Poortmans P, Senkus E, de Lafontan B, Bolla M, Largillier R, Lagneau E, Kadish S, Lemanski C, Ozsahin M, Belkacémi Y: Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network. Radiother Oncol. 2007, 85: 355-61. 10.1016/j.radonc.2007.10.015.CrossRefPubMed
25.
go back to reference Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, Mankin HJ, Kirsch DG, Rosenberg AE, Nielsen GP, Desphpande V, Suit HD, DeLaney TF, Yoon SS: Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol. 2007, 14: 1953-67. 10.1245/s10434-006-9335-y.CrossRefPubMed Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, Mankin HJ, Kirsch DG, Rosenberg AE, Nielsen GP, Desphpande V, Suit HD, DeLaney TF, Yoon SS: Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol. 2007, 14: 1953-67. 10.1245/s10434-006-9335-y.CrossRefPubMed
26.
go back to reference Monroe AT, Feigenberg SJ, Mendenhall NP: Angiosarcoma after breast-conserving therapy. Cancer. 2003, 97: 1832-40. 10.1002/cncr.11277.CrossRefPubMed Monroe AT, Feigenberg SJ, Mendenhall NP: Angiosarcoma after breast-conserving therapy. Cancer. 2003, 97: 1832-40. 10.1002/cncr.11277.CrossRefPubMed
27.
go back to reference Raina V, Sengar M, Shukla NK, Deo SS, Mohanty BK, Sharma D, Ray R, Das P, Rath GK: Complete response from thalidomide in angiosarcoma after treatment of breast cancer. J Clin Oncol. 2007, 25: 900-1. 10.1200/JCO.2006.09.7261.CrossRefPubMed Raina V, Sengar M, Shukla NK, Deo SS, Mohanty BK, Sharma D, Ray R, Das P, Rath GK: Complete response from thalidomide in angiosarcoma after treatment of breast cancer. J Clin Oncol. 2007, 25: 900-1. 10.1200/JCO.2006.09.7261.CrossRefPubMed
Metadata
Title
High grade angiosarcoma arising in fibroadenoma
Authors
Emina Babarović
Gordana Zamolo
Elvira Mustać
Miroslav Strčić
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2011
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-6-125

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