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Abdominal Radiology

Published in:

24-12-2023 | Hepatocellular Carcinoma | Hepatobiliary

Ultrasound findings of hepatic epithelioid hemangioendothelioma: comparison with other malignant hepatic tumors

Authors: Yadan Xu, Kailing Chen, Qi Zhang, Yang Tang, Benhua Xu, Xi Wang, Chaolun Li, Hantao Wang, Wenping Wang

Published in: Abdominal Radiology | Issue 3/2024

Abstract

Purpose

To investigate and compare the ultrasonic features of hepatic epithelioid hemangioendothelioma (HEHE) and other common hepatic malignancies, such as hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and hepatic metastatic tumor (HMT).

Methods

A total of 37 patients with pathologically proven HEHE, 37 HCC cases, 37 ICC cases, and 37 HMT cases were enrolled from single hospital. The clinical characteristics and ultrasonic features of all cases were summarized and statistically analyzed.

Results

There were significant differences in sex and age between the HEHE group and other three groups (P < 0.001). The probability of HEHE infection with hepatitis B virus was lower than that of HCC and ICC groups (P < 0.05). The probability of elevated serum tumor markers in HEHE was significantly lower than that in the other three groups (P < 0.05). On conventional ultrasound (CUS), the probability of multiple lesions in HEHE was significantly higher than that in the other three groups (P < 0.05). On contrast-enhanced ultrasound (CEUS), the time to wash out in HEHE was significantly shorter than that of the other three groups (P < 0.001). The proportion of synchronous or slow enhancement in HEHE was significantly higher than that of the other three groups (P < 0.001). The proportion of HEHE with iso- or hypo-enhancement was significantly higher than in HCC and HMT groups (P < 0.05).

Conclusion

HEHE mainly performed multiple hypoechoic lesions on CUS and displayed greater odds of synchronous enhancement in arterial phase, iso- or hypo-enhancement in peak time and wash out more quickly on CEUS, which allowed for differentiation from other common malignant tumors.

Graphical abstract

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Title: Ultrasound findings of hepatic epithelioid hemangioendothelioma: comparison with other malignant hepatic tumors
Authors: Yadan Xu
Kailing Chen
Qi Zhang
Yang Tang
Benhua Xu
Xi Wang
Chaolun Li
Hantao Wang
Wenping Wang
Publication date: 24-12-2023
Publisher: Springer US
Keywords: Hepatocellular Carcinoma
Hepatocellular Carcinoma
Cholangiocarcinoma
Cholangiocarcinoma
Published in: Abdominal Radiology / Issue 3/2024
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI: https://doi.org/10.1007/s00261-023-04126-2

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