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Cancer Cell International
Published in: Cancer Cell International 1/2020

Open Access 01-12-2020 | Hepatocellular Carcinoma | Review

The emerging roles of non-coding competing endogenous RNA in hepatocellular carcinoma

Authors: Gang Xu, Wei-Yu Xu, Yao Xiao, Bao Jin, Shun-Da Du, Yi-lei Mao, Zhong-Tao Zhang

Published in: Cancer Cell International | Issue 1/2020

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Abstract

Accumulating evidence has emerged revealing that noncoding RNAs (ncRNAs) play essential roles in the occurrence and development of hepatocellular carcinoma (HCC). However, the complicated regulatory interactions among various ncRNAs in the development of HCC are not entirely understood. The newly discovered mechanism of competing endogenous RNAs (ceRNAs) uncovered regulatory interactions among different varieties of RNAs. In recent years, a growing number of studies have suggested that ncRNAs, including long ncRNAs, circular RNAs and pseudogenes, play major roles in the biological functions of the ceRNA network in HCC. These ncRNAs can share microRNA response elements to affect microRNA affinity with target RNAs, thus regulating gene expression at the transcriptional level and both physiological and pathological processes. The ncRNAs that function as ceRNAs are involved in diverse biological processes in HCC cells, such as tumor cell proliferation, epithelial-mesenchymal transition, invasion, metastasis and chemoresistance. Based on these findings, ncRNAs that act as ceRNAs may be promising candidates for clinical diagnosis and treatments. In this review, we discuss the mechanisms and research methods of ceRNA networks. We also reviewed the recent advances in studying the roles of ncRNAs as ceRNAs in HCC and highlight possible directions and possibilities of ceRNAs as diagnostic biomarkers or therapeutic targets. Finally, the limitations, gaps in knowledge and opportunities for future research are also discussed.
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Metadata
Title
The emerging roles of non-coding competing endogenous RNA in hepatocellular carcinoma
Authors
Gang Xu
Wei-Yu Xu
Yao Xiao
Bao Jin
Shun-Da Du
Yi-lei Mao
Zhong-Tao Zhang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2020
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-020-01581-5

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