Published in:
01-07-2019 | Hepatocellular Carcinoma | Classics in Abdominal Radiology
“Nodule-in-nodule” architecture of hepatocellular carcinoma
Published in: Abdominal Radiology | Issue 7/2019
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The “nodule-in-nodule” architecture of hepatocellular carcinoma (HCC) is defined by the presence of one or more smaller inner nodules having different imaging features than a larger outer nodule (Fig. 1) [1]. This appearance is a variant of the “mosaic” architecture of HCC, that is defined as the presence of randomly distributed internal nodules or compartments, with different imaging features regarding enhancement, attenuation, intensity, and size [1, 2].
Fig. 1
Schematic representation of nodule-in-nodule architecture of hepatocellular carcinoma. A single nodule is located within a larger mass. The nodule and the larger mass typically have different attenuation/intensity and enhancement
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