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Open Access 01-05-2021 | Hepatocellular Carcinoma | Original Article

Intraoperative Transfusion of Fresh Frozen Plasma Predicts Morbidity Following Partial Liver Resection for Hepatocellular Carcinoma

Authors: Jan Bednarsch, Zoltan Czigany, Isabella Lurje, Christian Trautwein, Tom Lüdde, Pavel Strnad, Nadine Therese Gaisa, Alexandra Barabasch, Philipp Bruners, Tom Ulmer, Sven Arke Lang, Ulf Peter Neumann, Georg Lurje

Published in: Journal of Gastrointestinal Surgery | Issue 5/2021

Abstract

Background

The reduction of perioperative morbidity is a main surgical goal in patients undergoing partial hepatectomy for hepatocellular carcinoma (HCC). Here, we investigated clinical determinants of perioperative morbidity in a European cohort of patients undergoing surgical resection for HCC.

Methods

A total 136 patients who underwent partial hepatectomy for HCC between 2011 and 2017 at our institution were included in this analysis. The associations between major surgical complications (Clavien-Dindo ≥ 3) and overall morbidity (Clavien-Dindo ≥ 1) with clinical variables were assessed using univariate and multivariable binary logistic regression analysis.

Results

Multivariable analysis identified the Child-Pugh-Score (CPS, HR = 3.23; p = 0.040), operative time (HR = 5.63; p = 0.003), and intraoperatively administered fresh frozen plasma (FFP, HR = 5.62; p = 0.001) as independent prognostic markers of major surgical complications, while only FFP (HR = 6.52; p = 0.001) was associated with morbidity in the multivariable analysis. The transfusion of FFP was not associated with perioperative liver functions tests.

Conclusions

The intraoperative administration of FFP is an important independent predictor of perioperative morbidity in patients undergoing partial hepatectomy for HCC.

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Title: Intraoperative Transfusion of Fresh Frozen Plasma Predicts Morbidity Following Partial Liver Resection for Hepatocellular Carcinoma
Authors: Jan Bednarsch
Zoltan Czigany
Isabella Lurje
Christian Trautwein
Tom Lüdde
Pavel Strnad
Nadine Therese Gaisa
Alexandra Barabasch
Philipp Bruners
Tom Ulmer
Sven Arke Lang
Ulf Peter Neumann
Georg Lurje
Publication date: 01-05-2021
Publisher: Springer US
Keywords: Hepatocellular Carcinoma
Hepatocellular Carcinoma
Published in: Journal of Gastrointestinal Surgery / Issue 5/2021
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-020-04652-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intraoperative Transfusion of Fresh Frozen Plasma Predicts Morbidity Following Partial Liver Resection for Hepatocellular Carcinoma

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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