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Journal of Experimental & Clinical Cancer Research

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01-12-2021 | Hepatocellular Carcinoma | Review

Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets

Authors: Xiang-Yuan Luo, Kong-Ming Wu, Xing-Xing He

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2021

Abstract

Although hepatocellular carcinoma (HCC) is one of the deadliest health burdens worldwide, few drugs are available for its clinical treatment. However, in recent years, major breakthroughs have been made in the development of new drugs due to intensive fundamental research and numerous clinical trials in HCC. Traditional systemic therapy schemes and emerging immunotherapy strategies have both advanced. Between 2017 and 2020, the United States Food and Drug Administration (FDA) approved a variety of drugs for the treatment of HCC, including multikinase inhibitors (regorafenib, lenvatinib, cabozantinib, and ramucirumab), immune checkpoint inhibitors (nivolumab and pembrolizumab), and bevacizumab combined with atezolizumab. Currently, there are more than 1000 ongoing clinical trials involving HCC, which represents a vibrant atmosphere in the HCC drug research and development field. Additionally, traditional Chinese medicine approaches are being gradually optimized. This review summarizes FDA-approved agents for HCC, elucidates promising agents evaluated in clinical phase I/II/III trials and identifies emerging targets for HCC treatment. In addition, we introduce the development of HCC drugs in China. Finally, we discuss potential problems in HCC drug therapy and possible future solutions and indicate future directions for the development of drugs for HCC treatment.

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Title: Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets
Authors: Xiang-Yuan Luo
Kong-Ming Wu
Xing-Xing He
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Hepatocellular Carcinoma
Hepatocellular Carcinoma
Cabozantinib
Lenvatinib
Regorafenib
Sorafenib
Ramucirumab
Published in: Journal of Experimental & Clinical Cancer Research / Issue 1/2021
Electronic ISSN: 1756-9966
DOI: https://doi.org/10.1186/s13046-021-01968-w

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