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01-02-2016 | Original Article

Hepatitis E virus infection activates signal regulator protein α to down-regulate type I interferon

Authors: Fen Huang, Chenchen Yang, Wenhai Yu, Yanhong Bi, Feiyan Long, Jue Wang, Yunlong Li, Shenrong Jing

Published in: Immunologic Research | Issue 1/2016

Abstract

Hepatitis E virus (HEV) is a major cause of enterically transmitted acute hepatitis worldwide. However, the mechanism of HEV replication is unclear. Type I interferon is the first defense line of host against viral infection. Signal regulator protein α (SIRP-α) plays an important role in negative regulation of innate immunity. In the present study, HEV infection significantly activated the expression of SIRP-α and down-regulated phosphorylation of IRF3, consequently resulted in suppression of type I interferon (IFN-β). In conclusion, HEV exploited SIRP-α to negative regulated IFN-β of the host innate immune system to promote viral infection. It suggested that interfering with the functions of SIRP-α should be considered as a potential therapeutic approach to the prevention and treatment of HEV infection.

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Title: Hepatitis E virus infection activates signal regulator protein α to down-regulate type I interferon
Authors: Fen Huang
Chenchen Yang
Wenhai Yu
Yanhong Bi
Feiyan Long
Jue Wang
Yunlong Li
Shenrong Jing
Publication date: 01-02-2016
Publisher: Springer US
Published in: Immunologic Research / Issue 1/2016
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-015-8729-y

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Springer Medicine

Hepatitis E virus infection activates signal regulator protein α to down-regulate type I interferon

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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