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01-07-2010

Hepatitis C virus evasion of adaptive immune responses: a model for viral persistence

Authors: Kelly P. Burke, Andrea L. Cox

Published in: Immunologic Research | Issue 1-3/2010

Abstract

Hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of cirrhosis and hepatocellular carcinoma. Approximately 80% of those acutely infected clear the infection, whereas the remaining 20% progress to chronic infection. Hepatitis C thus provides a model in which successful and unsuccessful responses can be compared to better understand the human response to viral infection. Our laboratory studies the strategies by which HCV evades the adaptive immune response. This review describes the impact of viral mutation on T cell recognition, the role of cell surface inhibitory receptors in recognition of HCV, and the development of antibodies that neutralize HCV infection. Understanding what constitutes an effective immune response in the control of HCV may enable the development of prophylactic and therapeutic vaccines for HCV and other chronic viral infections.

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Title: Hepatitis C virus evasion of adaptive immune responses: a model for viral persistence
Authors: Kelly P. Burke
Andrea L. Cox
Publication date: 01-07-2010
Publisher: Humana Press Inc
Published in: Immunologic Research / Issue 1-3/2010
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-009-8152-3

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Springer Medicine

Hepatitis C virus evasion of adaptive immune responses: a model for viral persistence

Abstract

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Abstract

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