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Published in: European Radiology 5/2014

01-05-2014 | Hepatobiliary-Pancreas

Hepatic cysts treated with percutaneous ethanol sclerotherapy: time to extend the indications to haemorrhagic cysts and polycystic liver disease

Authors: Julie Benzimra, Maxime Ronot, David Fuks, Mohamed Abdel-Rehim, Annie Sibert, Olivier Farges, Valérie Vilgrain

Published in: European Radiology | Issue 5/2014

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Abstract

Objectives

To describe the long-term clinical and morphological outcome of symptomatic hepatic cysts treated with percutaneous ethanol sclerotherapy (PES).

Methods

From December 2003 to September 2011, all patients with hepatic cysts undergoing PES with a follow-up after 12 months were included. Evolution of the volume of the cysts and clinical and biological data were recorded. Features of the cyst were evaluated in each patient: simple, haemorrhagic or developed on underlying polycystic liver disease (PCLD).

Results

Fifty-eight cysts (median volume 666 mL) were treated in 57 patients (52 women, mean age 58 years (18–80)). Twenty-two patients (39 %) had simple hepatic cysts, 19 (33 %) had dominant cysts on PCLD and 20 had haemorrhagic cysts (34.5 %), including 4 with PCLD. After a mean 27.3 months of follow-up, the final median cystic volume was 13.5 mL (p < 0.0001), and the median reduction in cyst volume was 94 % (58–100 %). Treatment was satisfactory in 95 % of the patients (54/57) (symptoms disappeared in 45/57 (79 %), decreased in 9/57 (16 %)). There was no clinical or morphological difference between patients with PCLD, haemorrhagic cysts or simple cysts.

Conclusion

The clinical and morphological efficacy of a single session of PES is very high, regardless of the presence of intracystic haemorrhage or underlying PCLD.

Key Points

The clinical efficacy of percutaneous ethanol sclerotherapy is very high.
Haemorrhagic content should not be a contraindication for percutaneous sclerotherapy.
Dominant cysts on polycystic liver disease should be treated with PES.
Imaging follow-up should not be performed shortly after the procedure.
Appendix
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Literature
1.
go back to reference Gaines PA, Sampson MA (1989) The prevalence and characterization of simple hepatic cysts by ultrasound examination. Br J Radiol 62:335–337PubMedCrossRef Gaines PA, Sampson MA (1989) The prevalence and characterization of simple hepatic cysts by ultrasound examination. Br J Radiol 62:335–337PubMedCrossRef
2.
go back to reference Caremani M, Vincenti A, Benci A, Sassoli S, Tacconi D (1993) Echographic epidemiology of non-parasitic hepatic cysts. J Clin Ultrasound 21:115–118PubMedCrossRef Caremani M, Vincenti A, Benci A, Sassoli S, Tacconi D (1993) Echographic epidemiology of non-parasitic hepatic cysts. J Clin Ultrasound 21:115–118PubMedCrossRef
3.
go back to reference Redston MS, Wanless IR (1996) The hepatic von Meyenburg complex: prevalence and association with hepatic and renal cysts among 2843 autopsies [corrected]. Mod Pathol 9:233–237PubMed Redston MS, Wanless IR (1996) The hepatic von Meyenburg complex: prevalence and association with hepatic and renal cysts among 2843 autopsies [corrected]. Mod Pathol 9:233–237PubMed
4.
go back to reference Carrim ZI, Murchison JT (2003) The prevalence of simple renal and hepatic cysts detected by spiral computed tomography. Clin Radiol 58:626–629PubMedCrossRef Carrim ZI, Murchison JT (2003) The prevalence of simple renal and hepatic cysts detected by spiral computed tomography. Clin Radiol 58:626–629PubMedCrossRef
5.
go back to reference Frisell J, Rojdmark S, Arvidsson H, Lundh G (1979) Compression of the inferior caval vein–a rare complication of a large non-parasitic liver cyst. Acta Med Scand 205:541–542PubMedCrossRef Frisell J, Rojdmark S, Arvidsson H, Lundh G (1979) Compression of the inferior caval vein–a rare complication of a large non-parasitic liver cyst. Acta Med Scand 205:541–542PubMedCrossRef
6.
go back to reference Howard RJ, Hanson RF, Delaney JP (1976) Jaundice associated with polycystic liver disease. Relief by surgical decompression of the cysts. Arch Surg 111:816–817PubMedCrossRef Howard RJ, Hanson RF, Delaney JP (1976) Jaundice associated with polycystic liver disease. Relief by surgical decompression of the cysts. Arch Surg 111:816–817PubMedCrossRef
7.
go back to reference Newman KD, Torres VE, Rakela J, Nagorney DM (1990) Treatment of highly symptomatic polycystic liver disease. Preliminary experience with a combined hepatic resection-fenestration procedure. Ann Surg 212:30–37PubMedCentralPubMedCrossRef Newman KD, Torres VE, Rakela J, Nagorney DM (1990) Treatment of highly symptomatic polycystic liver disease. Preliminary experience with a combined hepatic resection-fenestration procedure. Ann Surg 212:30–37PubMedCentralPubMedCrossRef
8.
go back to reference Henne-Bruns D, Klomp HJ, Kremer B (1993) Non-parasitic liver cysts and polycystic liver disease: results of surgical treatment. Hepatogastroenterology 40:1–5PubMed Henne-Bruns D, Klomp HJ, Kremer B (1993) Non-parasitic liver cysts and polycystic liver disease: results of surgical treatment. Hepatogastroenterology 40:1–5PubMed
9.
go back to reference Que F, Nagorney DM, Gross JB Jr, Torres VE (1995) Liver resection and cyst fenestration in the treatment of severe polycystic liver disease. Gastroenterology 108:487–494PubMedCrossRef Que F, Nagorney DM, Gross JB Jr, Torres VE (1995) Liver resection and cyst fenestration in the treatment of severe polycystic liver disease. Gastroenterology 108:487–494PubMedCrossRef
10.
go back to reference Gigot JF, Legrand M, Hubens G et al (1996) Laparoscopic treatment of nonparasitic liver cysts: adequate selection of patients and surgical technique. World J Surg 20:556–561PubMedCrossRef Gigot JF, Legrand M, Hubens G et al (1996) Laparoscopic treatment of nonparasitic liver cysts: adequate selection of patients and surgical technique. World J Surg 20:556–561PubMedCrossRef
11.
go back to reference Koperna T, Vogl S, Satzinger U, Schulz F (1997) Nonparasitic cysts of the liver: results and options of surgical treatment. World J Surg 21:850–854PubMedCrossRef Koperna T, Vogl S, Satzinger U, Schulz F (1997) Nonparasitic cysts of the liver: results and options of surgical treatment. World J Surg 21:850–854PubMedCrossRef
12.
go back to reference Emmermann A, Zornig C, Lloyd DM, Peiper M, Bloechle C, Broelsch CE (1997) Laparoscopic treatment of nonparasitic cysts of the liver with omental transposition flap. Surg Endosc 11:734–736PubMedCrossRef Emmermann A, Zornig C, Lloyd DM, Peiper M, Bloechle C, Broelsch CE (1997) Laparoscopic treatment of nonparasitic cysts of the liver with omental transposition flap. Surg Endosc 11:734–736PubMedCrossRef
13.
go back to reference Paterson-Brown S, Garden OJ (1991) Laser-assisted laparoscopic excision of liver cyst. Br J Surg 78:1047PubMedCrossRef Paterson-Brown S, Garden OJ (1991) Laser-assisted laparoscopic excision of liver cyst. Br J Surg 78:1047PubMedCrossRef
14.
go back to reference Regev A, Reddy KR, Berho M et al (2001) Large cystic lesions of the liver in adults: a 15-year experience in a tertiary center. J Am Coll Surg 193:36–45PubMedCrossRef Regev A, Reddy KR, Berho M et al (2001) Large cystic lesions of the liver in adults: a 15-year experience in a tertiary center. J Am Coll Surg 193:36–45PubMedCrossRef
15.
go back to reference Tagaya N, Nemoto T, Kubota K (2003) Long-term results of laparoscopic unroofing of symptomatic solitary nonparasitic hepatic cysts. Surg Laparosc Endosc Percutan Tech 13:76–79PubMedCrossRef Tagaya N, Nemoto T, Kubota K (2003) Long-term results of laparoscopic unroofing of symptomatic solitary nonparasitic hepatic cysts. Surg Laparosc Endosc Percutan Tech 13:76–79PubMedCrossRef
16.
go back to reference Saini S, Mueller PR, Ferrucci JT Jr, Simeone JF, Wittenberg J, Butch RJ (1983) Percutaneous aspiration of hepatic cysts does not provide definitive therapy. AJR Am J Roentgenol 141:559–560PubMedCrossRef Saini S, Mueller PR, Ferrucci JT Jr, Simeone JF, Wittenberg J, Butch RJ (1983) Percutaneous aspiration of hepatic cysts does not provide definitive therapy. AJR Am J Roentgenol 141:559–560PubMedCrossRef
17.
18.
go back to reference Trinkl W, Sassaris M, Hunter FM (1985) Nonsurgical treatment for symptomatic nonparasitic liver cyst. Am J Gastroenterol 80:907–911PubMed Trinkl W, Sassaris M, Hunter FM (1985) Nonsurgical treatment for symptomatic nonparasitic liver cyst. Am J Gastroenterol 80:907–911PubMed
19.
go back to reference Andersson R, Jeppsson B, Lunderquist A, Bengmark S (1989) Alcohol sclerotherapy of non-parasitic cysts of the liver. Br J Surg 76:254–255PubMedCrossRef Andersson R, Jeppsson B, Lunderquist A, Bengmark S (1989) Alcohol sclerotherapy of non-parasitic cysts of the liver. Br J Surg 76:254–255PubMedCrossRef
20.
go back to reference Kairaluoma MI, Leinonen A, Stahlberg M, Paivansalo M, Kiviniemi H, Siniluoto T (1989) Percutaneous aspiration and alcohol sclerotherapy for symptomatic hepatic cysts. An alternative to surgical intervention. Ann Surg 210:208–215PubMedCentralPubMedCrossRef Kairaluoma MI, Leinonen A, Stahlberg M, Paivansalo M, Kiviniemi H, Siniluoto T (1989) Percutaneous aspiration and alcohol sclerotherapy for symptomatic hepatic cysts. An alternative to surgical intervention. Ann Surg 210:208–215PubMedCentralPubMedCrossRef
21.
go back to reference Buckenham TM, Teele R (1990) Percutaneous therapy for hepatic cysts. Case report and review of literature. Australas Radiol 34:159–161PubMedCrossRef Buckenham TM, Teele R (1990) Percutaneous therapy for hepatic cysts. Case report and review of literature. Australas Radiol 34:159–161PubMedCrossRef
22.
go back to reference Simonetti G, Profili S, Sergiacomi GL, Meloni GB, Orlacchio A (1993) Percutaneous treatment of hepatic cysts by aspiration and sclerotherapy. Cardiovasc Intervent Radiol 16:81–84PubMedCrossRef Simonetti G, Profili S, Sergiacomi GL, Meloni GB, Orlacchio A (1993) Percutaneous treatment of hepatic cysts by aspiration and sclerotherapy. Cardiovasc Intervent Radiol 16:81–84PubMedCrossRef
23.
go back to reference Garber S, Mathieson J, Cooperberg PL (1993) Percutaneous sclerosis of hepatic cysts to treat obstructive jaundice in a patient with polycystic liver disease. AJR Am J Roentgenol 161:77–78PubMedCrossRef Garber S, Mathieson J, Cooperberg PL (1993) Percutaneous sclerosis of hepatic cysts to treat obstructive jaundice in a patient with polycystic liver disease. AJR Am J Roentgenol 161:77–78PubMedCrossRef
24.
go back to reference Montorsi M, Torzilli G, Fumagalli U et al (1994) Percutaneous alcohol sclerotherapy of simple hepatic cysts. Results from a multicentre survey in Italy. HPB Surg 8:89–94PubMedCentralPubMedCrossRef Montorsi M, Torzilli G, Fumagalli U et al (1994) Percutaneous alcohol sclerotherapy of simple hepatic cysts. Results from a multicentre survey in Italy. HPB Surg 8:89–94PubMedCentralPubMedCrossRef
25.
go back to reference vanSonnenberg E, Wroblicka JT, D'Agostino HB et al (1994) Symptomatic hepatic cysts: percutaneous drainage and sclerosis. Radiology 190:387–392PubMed vanSonnenberg E, Wroblicka JT, D'Agostino HB et al (1994) Symptomatic hepatic cysts: percutaneous drainage and sclerosis. Radiology 190:387–392PubMed
26.
go back to reference Tikkakoski T, Makela JT, Leinonen S et al (1996) Treatment of symptomatic congenital hepatic cysts with single-session percutaneous drainage and ethanol sclerosis: technique and outcome. J Vasc Interv Radiol 7:235–239PubMedCrossRef Tikkakoski T, Makela JT, Leinonen S et al (1996) Treatment of symptomatic congenital hepatic cysts with single-session percutaneous drainage and ethanol sclerosis: technique and outcome. J Vasc Interv Radiol 7:235–239PubMedCrossRef
27.
go back to reference Larssen TB, Viste A, Jensen DK, Sondenaa K, Rokke O, Horn A (1997) Single-session alcohol sclerotherapy in benign symptomatic hepatic cysts. Acta Radiol 38:993–997PubMedCrossRef Larssen TB, Viste A, Jensen DK, Sondenaa K, Rokke O, Horn A (1997) Single-session alcohol sclerotherapy in benign symptomatic hepatic cysts. Acta Radiol 38:993–997PubMedCrossRef
28.
go back to reference Larssen TB, Jensen DK, Viste A, Horn A (1999) Single-session alcohol sclerotherapy in symptomatic benign hepatic cysts. Long-term results. Acta Radiol 40:636–638PubMedCrossRef Larssen TB, Jensen DK, Viste A, Horn A (1999) Single-session alcohol sclerotherapy in symptomatic benign hepatic cysts. Long-term results. Acta Radiol 40:636–638PubMedCrossRef
29.
go back to reference Okano A, Hajiro K, Takakuwa H, Nishio A (2000) Alcohol sclerotherapy of hepatic cysts: its effect in relation to ethanol concentration. Hepatol Res 17:179–184PubMedCrossRef Okano A, Hajiro K, Takakuwa H, Nishio A (2000) Alcohol sclerotherapy of hepatic cysts: its effect in relation to ethanol concentration. Hepatol Res 17:179–184PubMedCrossRef
30.
go back to reference Moorthy K, Mihssin N, Houghton PW (2001) The management of simple hepatic cysts: sclerotherapy or laparoscopic fenestration. Ann R Coll Surg Engl 83:409–414PubMedCentralPubMed Moorthy K, Mihssin N, Houghton PW (2001) The management of simple hepatic cysts: sclerotherapy or laparoscopic fenestration. Ann R Coll Surg Engl 83:409–414PubMedCentralPubMed
31.
go back to reference Larssen TB, Rosendahl K, Horn A, Jensen DK, Rorvik J (2003) Single-session alcohol sclerotherapy in symptomatic benign hepatic cysts performed with a time of exposure to alcohol of 10 min: initial results. Eur Radiol 13:2627–2632PubMedCrossRef Larssen TB, Rosendahl K, Horn A, Jensen DK, Rorvik J (2003) Single-session alcohol sclerotherapy in symptomatic benign hepatic cysts performed with a time of exposure to alcohol of 10 min: initial results. Eur Radiol 13:2627–2632PubMedCrossRef
32.
go back to reference Kimura F, Miyazaki M, Itoh H, Suwa T, Sugiura T, Shinoda T (2005) Repeated instillation of a limited volume of ethanol for the treatment of symptomatic hepatic cysts. Hepatogastroenterology 52:1147–1150PubMed Kimura F, Miyazaki M, Itoh H, Suwa T, Sugiura T, Shinoda T (2005) Repeated instillation of a limited volume of ethanol for the treatment of symptomatic hepatic cysts. Hepatogastroenterology 52:1147–1150PubMed
33.
go back to reference Yang CF, Liang HL, Pan HB et al (2006) Single-session prolonged alcohol-retention sclerotherapy for large hepatic cysts. AJR Am J Roentgenol 187:940–943PubMedCrossRef Yang CF, Liang HL, Pan HB et al (2006) Single-session prolonged alcohol-retention sclerotherapy for large hepatic cysts. AJR Am J Roentgenol 187:940–943PubMedCrossRef
34.
go back to reference Blonski WC, Campbell MS, Faust T, Metz DC (2006) Successful aspiration and ethanol sclerosis of a large, symptomatic, simple liver cyst: case presentation and review of the literature. World J Gastroenterol 12:2949–2954PubMed Blonski WC, Campbell MS, Faust T, Metz DC (2006) Successful aspiration and ethanol sclerosis of a large, symptomatic, simple liver cyst: case presentation and review of the literature. World J Gastroenterol 12:2949–2954PubMed
35.
go back to reference Zerem E, Imamovic G, Omerovic S (2008) Percutaneous treatment of symptomatic non-parasitic benign liver cysts: single-session alcohol sclerotherapy versus prolonged catheter drainage with negative pressure. Eur Radiol 18:400–406PubMedCrossRef Zerem E, Imamovic G, Omerovic S (2008) Percutaneous treatment of symptomatic non-parasitic benign liver cysts: single-session alcohol sclerotherapy versus prolonged catheter drainage with negative pressure. Eur Radiol 18:400–406PubMedCrossRef
36.
go back to reference Tanaka S, Watanabe M, Akagi S et al (1998) Laparoscopic fenestration in combination with ethanol sclerotherapy prevents a recurrence of symptomatic giant liver cyst. Surg Laparosc Endosc 8:453–456PubMedCrossRef Tanaka S, Watanabe M, Akagi S et al (1998) Laparoscopic fenestration in combination with ethanol sclerotherapy prevents a recurrence of symptomatic giant liver cyst. Surg Laparosc Endosc 8:453–456PubMedCrossRef
37.
go back to reference Ferris JV (2003) Serial ethanol ablation of multiple hepatic cysts as an alternative to liver transplantation. AJR Am J Roentgenol 180:472–474PubMedCrossRef Ferris JV (2003) Serial ethanol ablation of multiple hepatic cysts as an alternative to liver transplantation. AJR Am J Roentgenol 180:472–474PubMedCrossRef
38.
go back to reference Erdogan D, van Delden OM, Rauws EA et al (2007) Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease. World J Gastroenterol 13:3095–3100PubMed Erdogan D, van Delden OM, Rauws EA et al (2007) Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease. World J Gastroenterol 13:3095–3100PubMed
39.
go back to reference Hahn ST, Han SY, Yun EH et al (2008) Recurrence after percutaneous ethanol ablation of simple hepatic, renal, and splenic cysts: is it true recurrence requiring an additional treatment? Acta Radiol 49:982–986PubMedCrossRef Hahn ST, Han SY, Yun EH et al (2008) Recurrence after percutaneous ethanol ablation of simple hepatic, renal, and splenic cysts: is it true recurrence requiring an additional treatment? Acta Radiol 49:982–986PubMedCrossRef
40.
go back to reference Mortele KJ, Ros PR (2001) Cystic focal liver lesions in the adult: differential CT and MR imaging features. RadioGraphics 21:895–910PubMedCrossRef Mortele KJ, Ros PR (2001) Cystic focal liver lesions in the adult: differential CT and MR imaging features. RadioGraphics 21:895–910PubMedCrossRef
41.
go back to reference Qian Q, Li A, King BF et al (2003) Clinical profile of autosomal dominant polycystic liver disease. Hepatology 37:164–171PubMedCrossRef Qian Q, Li A, King BF et al (2003) Clinical profile of autosomal dominant polycystic liver disease. Hepatology 37:164–171PubMedCrossRef
42.
go back to reference Vilgrain V, Silbermann O, Benhamou JP, Nahum H (1993) MR imaging in intracystic hemorrhage of simple hepatic cysts. Abdom Imaging 18:164–167PubMedCrossRef Vilgrain V, Silbermann O, Benhamou JP, Nahum H (1993) MR imaging in intracystic hemorrhage of simple hepatic cysts. Abdom Imaging 18:164–167PubMedCrossRef
43.
go back to reference Wernet A, Sibert A, Paugam-Burtz C et al (2008) Ethanol-induced coma after therapeutic ethanol injection of a hepatic cyst. Anesthesiology 108:328–329PubMedCrossRef Wernet A, Sibert A, Paugam-Burtz C et al (2008) Ethanol-induced coma after therapeutic ethanol injection of a hepatic cyst. Anesthesiology 108:328–329PubMedCrossRef
44.
go back to reference Van Keimpema L, De Koning DB, Van Hoek B et al (2011) Patients with isolated polycystic liver disease referred to liver centres: clinical characterization of 137 cases. Liver Int 31:92–98PubMedCrossRef Van Keimpema L, De Koning DB, Van Hoek B et al (2011) Patients with isolated polycystic liver disease referred to liver centres: clinical characterization of 137 cases. Liver Int 31:92–98PubMedCrossRef
45.
go back to reference Nakaoka R, Das K, Kudo M, Chung H, Innoue T (2009) Percutaneous aspiration and ethanolamine oleate sclerotherapy for sustained resolution of symptomatic polycystic liver disease: an initial experience. AJR Am J Roentgenol 193:1540–1545PubMedCrossRef Nakaoka R, Das K, Kudo M, Chung H, Innoue T (2009) Percutaneous aspiration and ethanolamine oleate sclerotherapy for sustained resolution of symptomatic polycystic liver disease: an initial experience. AJR Am J Roentgenol 193:1540–1545PubMedCrossRef
46.
go back to reference Aussilhou B, Doufle G, Hubert C et al (2010) Extended liver resection for polycystic liver disease can challenge liver transplantation. Ann Surg 252:735–743PubMedCrossRef Aussilhou B, Doufle G, Hubert C et al (2010) Extended liver resection for polycystic liver disease can challenge liver transplantation. Ann Surg 252:735–743PubMedCrossRef
47.
go back to reference Fong ZV, Wolf AM, Doria C, Berger AC, Rosato EL, Palazzo F (2012) Hemorrhagic hepatic cyst: report of a case and review of the literature with emphasis on clinical approach and management. J Gastrointest Surg 16:1782–1789PubMedCrossRef Fong ZV, Wolf AM, Doria C, Berger AC, Rosato EL, Palazzo F (2012) Hemorrhagic hepatic cyst: report of a case and review of the literature with emphasis on clinical approach and management. J Gastrointest Surg 16:1782–1789PubMedCrossRef
Metadata
Title
Hepatic cysts treated with percutaneous ethanol sclerotherapy: time to extend the indications to haemorrhagic cysts and polycystic liver disease
Authors
Julie Benzimra
Maxime Ronot
David Fuks
Mohamed Abdel-Rehim
Annie Sibert
Olivier Farges
Valérie Vilgrain
Publication date
01-05-2014
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 5/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3117-x

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