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01-11-2018 | Original Article

Hematology and serum biochemistry of growing New Zealand White (NZW) rabbits administered Panax ginseng extracts

Authors: T. C. Iwuji, U. Herbert, M. A. Oguike, I. P. Ogbuewu

Published in: Comparative Clinical Pathology | Issue 6/2018

Abstract

This study was conducted to evaluate the hematological and serum biochemical parameters of growing New Zealand White (NZW) rabbits administered Panax ginseng extracts (PGEs). A total of 48 NZW growing male (M) and female (F) rabbits (24 each) were used and the experiment lasted for 28 days. It was carried out in a randomized complete block design (RCBD), made up of T₁ (0.0 mg/ml of PGEs), T₂ (200.0 mg/ml of PGEs), and T₃ (400.0 mg/ml of PGEs) which was replicated thrice and sex served as the block. Packed cell volume (PCV) (34.03%), red blood cell (RBC) (5.52 × 10⁶/μl), white blood cell (WBC) (7.60 × 10³/μl), and heterophil (34.00%) counts of the growing male NZW rabbits were significantly (P < 0.05) higher in MT₃ rabbits. PGEs positively affected mean corpuscular volume (MCV) of the male rabbits which recorded a significantly (P < 0.05) higher value in MT₃ (400.0 mg/ml of PGEs), but negatively affected the female rabbits which recorded a significantly (P < 0.05) higher value in FT₁ (0.0 mg/ml of PGEs). Total protein values were significantly (P < 0.05) different among the experimental rabbits, with the lowest value obtained from FT₃ (4.58 g/dl) rabbits. Globulin values of the rabbits were significantly (P < 0.05) lower in MT₃ and FT₃ rabbits. Serum cholesterol of the experimental rabbits were significantly (P < 0.05) lower in PGE-treated rabbits (MT₂, MT₃, FT₂, and FT₃). Alkaline phosphatase (ALP), alanine transaminase (ALT), and aspartate transaminase (AST) values of the growing female NZW rabbits were significantly (P < 0.05) lower in PGE-treated female rabbits. The result of this study suggests improved PCV, RBC, and cellular immunity in growing male NZW rabbits. It also suggests that PGEs have an anti-cholesterolemic effect on both male and female growing NZW rabbits.

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Title: Hematology and serum biochemistry of growing New Zealand White (NZW) rabbits administered Panax ginseng extracts
Authors: T. C. Iwuji
U. Herbert
M. A. Oguike
I. P. Ogbuewu
Publication date: 01-11-2018
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 6/2018
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-018-2795-1

At a glance: The STEP trials

Springer Medicine

Hematology and serum biochemistry of growing New Zealand White (NZW) rabbits administered Panax ginseng extracts

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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