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European Journal of Clinical Microbiology & Infectious Diseases
Published in: European Journal of Clinical Microbiology & Infectious Diseases 6/2019

01-06-2019 | Helicobacter Pylori | Review

Helicobacter pylori infection in children: an overview of diagnostic methods

Authors: Parisa Sabbagh, Mostafa Javanian, Veerendra Koppolu, VeneelaKrishna Rekha Vasigala, Soheil Ebrahimpour

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 6/2019

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Abstract

Children differ from adults regarding Helicobacter pylori (H. pylori) infection in many terms. H. pylori infection represents a key factor in the pathogenesis of duodenal ulcer and chronic gastritis in children. H. pylori infection causes some extraintestinal diseases as well as gastrointestinal diseases. Although, among these illnesses in children, symptoms like recurrent abdominal pain are not specific. Moreover, the role of the pathogen in the growth faltering, iron deficiency anemia, and asthma still remains controversial. A reliable method to detect H. pylori infection is a crucial issue, sand is still a matter of active debate. The tests applied for H. pylori diagnosis are grouped as either invasive or non-invasive methods. Invasive methods consist of endoscopic evaluation, the rapid urease test (RUT), histology, and bacterial culture. Non-invasive tests include the urea breath test (UBT), stool antigen test (SAT), serology, and molecular diagnostic approaches. Use of endoscopy is a pre-requisite for all invasive methods and poses difficulties in children as it is a difficult procedure and requires patient’s cooperation. For this reason, the non-invasive tests have been commonly used in children, although their accuracy is not very reliable in some cases. Invasive tests may be opted to confirm the diagnosis as and when needed. This review presents the diagnostic tests used to detect H. pylori infection in children.
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Metadata
Title
Helicobacter pylori infection in children: an overview of diagnostic methods
Authors
Parisa Sabbagh
Mostafa Javanian
Veerendra Koppolu
VeneelaKrishna Rekha Vasigala
Soheil Ebrahimpour
Publication date
01-06-2019
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Clinical Microbiology & Infectious Diseases / Issue 6/2019
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-019-03502-5

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