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BMC Gastroenterology
Published in: BMC Gastroenterology 1/2011

Open Access 01-12-2011 | Research article

Helicobacter pylori infection and circulating ghrelin levels - A systematic review

Authors: Chidi V Nweneka, Andrew M Prentice

Published in: BMC Gastroenterology | Issue 1/2011

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Abstract

Background

The nature of the association between ghrelin, an orexigenic hormone produced mainly in the stomach, and Helicobacter pylori (H pylori), a bacterium that colonises the stomach, is still controversial. We examined available evidence to determine whether an association exists between the two; and if one exists, in what direction.

Methods

We reviewed original English language studies on humans reporting circulating ghrelin levels in H pylori infected and un-infected participants; and circulating ghrelin levels before and after H pylori eradication. Meta-analyses were conducted for eligible studies by combining study specific estimates using the inverse variance method with weighted average for continuous outcomes in a random effects model.

Results

Seventeen out of 27 papers that reported ghrelin levels in H pylori positive and negative subjects found lower circulating ghrelin levels in H pylori positive subjects; while 10 found no difference. A meta-analysis of 19 studies with a total of 1801 participants showed a significantly higher circulating ghrelin concentration in H pylori negative participants than in H pylori positive participants (Effect estimate (95%CI) = -0.48 (-0.60, -0.36)). However, eradicating H pylori did not have any significant effect on circulating ghrelin levels (Effect estimate (95% CI) = 0.08 (-0.33, 0.16); Test for overall effect: Z = 0.67 (P = 0.5)).

Conclusions

We conclude that circulating ghrelin levels are lower in H pylori infected people compared to those not infected; but the relationship between circulating ghrelin and eradication of H pylori is more complex.
Appendix
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Literature
1.
Taniaka-Shintani M, Watanabe M: Distribution of ghrelin-immunoreactive cells in human gastric mucosa: comparison with that of parietal cells. Journal of gastroenterology. 2005, 40 (4): 345-349. 10.1007/s00535-004-1550-3.CrossRef
2.
Nwokolo CU, Freshwater DA, O'Hare P, Randeva HS: Plasma ghrelin following cure of Helicobacter pylori. Gut. 2003, 52 (5): 637-640. 10.1136/gut.52.5.637.CrossRefPubMedPubMedCentral
3.
Gokcel A, Gumurdulu Y, Kayaselcuk F, Serin E, Ozer B, Ozsahin AK, Guvener N: Helicobacter pylori has no effect on plasma ghrelin levels. European Journal of Endocrinology. 2003, 148 (4): 423-426. 10.1530/eje.0.1480423.CrossRefPubMed
4.
Abiko Y, Suzuki H, Masaoka T, Nomura S, Kurabayashi K, Hosoda H, Kangawa K, Hibi T: Enhanced plasma ghrelin levels in Helicobacter pylori-colonized, interleukin-1-receptor type 1-homozygous knockout (IL-1R1-/-) mice. World J Gastroenterol. 2005, 11 (27): 4148-4153.CrossRefPubMedPubMedCentral
5.
Anania C, Pacifico L, Castronovo A, Neaga M, Ferrara E, Schiavo E, Bonamico M, Chiesa C: Long-term effects of Helicobacter pylori eradication on the levels of circulating ghrelin and leptin concentrations and on body composition in prepubertal children. Helicobacter. 2007, 12 (4): 393-393.
6.
Choe YH, Lee JH, Lee HJ, Paik KH, Jin DK, Song SY, Lee JH: Ghrelin Levels in Gastric Mucosa before and after Eradication of Helicobacter pylori. Gut Liver. 2007, 1 (2): 132-137. 10.5009/gnl.2007.1.2.132.CrossRefPubMedPubMedCentral
7.
Choi JY, Hahm KB: [Ghrelin; influences on Helicobacter pylori-associated gastric diseases]. Korean J Gastroenterol. 2006, 48 (2): 75-81.PubMed
8.
9.
Weigt J, Malfertheiner P: Influence of Helicobacter pylori on gastric regulation of food intake. Curr Opin Clin Nutr Metab Care. 2009, 12 (5): 522-525. 10.1097/MCO.0b013e32832eb56e.CrossRefPubMed
10.
Checchi S, Montanaro A, Pasqui L, Ciuoli C, Cevenini G, Sestini F, Fioravanti C, Pacini F: Serum ghrelin as a marker of atrophic body gastritis in patients with parietal cell antibodies. Journal of Clinical Endocrinology & Metabolism. 2007, 92 (11): 4346-4351. 10.1210/jc.2007-0988.CrossRef
11.
Cindoruk M, Yetkin I, Deger SM, Karakan T, Kan E, Unal S: Influence of H pylori on plasma ghrelin in patients without atrophic gastritis. World Journal of Gastroenterology. 2007, 13 (10): 1595-1598.CrossRefPubMedPubMedCentral
12.
Czesnikiewicz-Guzik M, Bielanski W, Guzik TJ, Loster B, Konturek SJ: Helicobacter pylori in the oral cavity and its implications for gastric infection, periodontal health, immunology and dyspepsia. J Physiol Pharmacol. 2005, 56 (Suppl 6): 77-89.PubMed
13.
Czesnikiewicz-Guzik M, Loster B, Bielanski W, Guzik TJ, Konturek PC, Zapala J, Konturek SJ: Implications of oral Helicobacter pylori for the outcome of its gastric eradication therapy. Journal of Clinical Gastroenterology. 2007, 41 (2): 145-151. 10.1097/01.mcg.0000225654.85060.3d.CrossRefPubMed
14.
de Martel C, Haggerty TD, Corley DA, Vogelman JH, Orentreich N, Parsonnet J: Serum ghrelin levels and risk of subsequent adenocarcinoma of the esophagus. American Journal of Gastroenterology. 2007, 102 (6): 1166-1172. 10.1111/j.1572-0241.2007.01116.x.CrossRefPubMed
15.
Gao X, Kuang H, Liu X, Duan P, Yang Y, Ma Z: Circulating ghrelin/obestatin ratio in subjects with Helicobacter pylori infection. Nutrition. 2009, 25 (5): 506-511. 10.1016/j.nut.2008.11.002.CrossRefPubMed
16.
Jang EJ, Park SW, Park JS, Park SJ, Hahm KB, Paik SY, Sin MK, Lee ES, Oh SW, Park CY, et al: The influence of the eradication of Helicobacter pylori on gastric ghrelin, appetite, and body mass index in patients with peptic ulcer disease. Journal of gastroenterology and hepatology. 2008, 23 (Suppl 2): S278-285. 10.1111/j.1440-1746.2008.05415.x.CrossRefPubMed
17.
Konturek PC, Czesnikiewicz-Guzik M, Bielanski W, Konturek SJ: Involvement of Helicobacter pylori infection in neuro-hormonal control of food intake. Journal of Physiology & Pharmacology. 2006, 57 (Suppl 5): 67-81.
18.
Roper J, Francois F, Shue PL, Mourad MS, Pei Z, Olivares de Perez AZ, Perez-Perez GI, Tseng CH, Blaser MJ: Leptin and ghrelin in relation to Helicobacter pylori status in adult males. Journal of Clinical Endocrinology & Metabolism. 2008, 93 (6): 2350-2357. 10.1210/jc.2007-2057.CrossRef
19.
Salles N, Menard A, Georges A, Salzmann M, de Ledinghen V, de Mascarel A, Emeriau JP, Lamouliatte H, Megraud F: Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients. Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 2006, 61 (11): 1144-1150.CrossRef
20.
Shindo T, Futagami S, Hiratsuka T, Horie A, Hamamoto T, Ueki N, Kusunoki M, Miyake K, Gudis K, Tsukui T, et al: Comparison of Gastric Emptying and Plasma Ghrelin Levels in Patients with Functional Dyspepsia and Non-Erosive Reflux Disease. Digestion. 2009, 79 (2): 65-72. 10.1159/000205740.CrossRefPubMed
21.
Shiotani A, Miyanishi T, Uedo N, Iishi H: Helicobacter pylori infection is associated with reduced circulating ghrelin levels independent of body mass index. Helicobacter. 2005, 10 (5): 373-378. 10.1111/j.1523-5378.2005.00343.x.CrossRefPubMed
22.
Zub-Pokrowiecka A, Rembiasz K, Konturek SJ, Budzynski A, Konturek PC, Budzynski P: Ghrelin in diseases of the gastric mucosa associated with Helicobacter pylori infection. Med Sci Monit. 2010, 16 (10): CR493-500.PubMed
23.
Lee ES, Yoon YS, Park CY, Kim HS, Um TH, Baik HW, Jang EJ, Lee S, Park HS, Oh SW: Eradication of Helicobacter pylori increases ghrelin mRNA expression in the gastric mucosa. Journal of Korean Medical Science. 2010, 25 (2): 265-271. 10.3346/jkms.2010.25.2.265.CrossRefPubMedPubMedCentral
24.
Stec-Michalska K, Malicki S, Michalski B, Peczek L, Wisniewska-Jarosinska M, Nawrot B: Gastric ghrelin in relation to gender, stomach topography and Helicobacter pylori in dyspeptic patients. World Journal of Gastroenterology. 2009, 15 (43): 5409-5417. 10.3748/wjg.15.5409.CrossRefPubMedPubMedCentral
25.
Suzuki H, Masaoka T, Hosoda H, Nomura S, Ohara T, Kangawa K, Ishii H, Hibi T: Plasma ghrelin concentration correlates with the levels of serum pepsinogen I and pepsinogen I/II ratio - A possible novel and non-invasive marker for gastric atrophy. Hepato-Gastroenterology. 2004, 51 (59): 1249-1254.PubMed
26.
Pacifico L, Anania C, Osborn JF, Ferrara E, Schiavo E, Bonamico M, Chiesa C: Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children. European Journal of Endocrinology. 2008, 158 (3): 323-332. 10.1530/EJE-07-0438.CrossRefPubMed
27.
Nunes FA, Alves JS, Diniz MTC, Barbosa AJA: Helicobacter pylori infection and density of gastric ghrelin-producing cells in obese and Nonobese patients. Helicobacter. 2006, 11 (4): 368-368. 10.1111/j.1523-5378.2006.00419_10.x.CrossRef
28.
29.
Higgins JP, Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 2002, 21 (11): 1539-1558. 10.1002/sim.1186.CrossRefPubMed
30.
Chuang CH, Sheu BS, Yang HB, Lee SC, Kao AW, Cheng HC, Chang WL, Yao WJ: Gender difference of circulating ghrelin and leptin concentrations in chronic Helicobacter pylori infection. Helicobacter. 2009, 14 (1): 54-60. 10.1111/j.1523-5378.2009.00653.x.CrossRefPubMed
31.
D'Onghia V, Leoncini R, Carli R, Santoro A, Giglioni S, Sorbellini F, Marzocca G, Bernini A, Campagna S, Marinello E, et al: Circulating gastrin and ghrelin levels in patients with colorectal cancer: correlation with tumour stage, Helicobacter pylori infection and BMI. Biomedicine & Pharmacotherapy. 2007, 61 (2-3): 137-141. 10.1016/j.biopha.2006.08.007.CrossRef
32.
Plonka M, Konturek PC, Bielanski W, Pawlik T, Brzozowski T, Konturek SJ: Relationship between ghrelin and Helicobacter pylori infection in Polish adult shepherds and their children. Alimentary Pharmacology & Therapeutics. 2006, 24: 160-168. 10.1111/j.1365-2036.2006.00040.x.CrossRef
33.
Cindoruk M, Yetkin I, Deger SM, Karakan T, Kan E, Unal S: Influence of H pylori on plasma ghrelin in patients without atrophic gastritis. World J Gastroenterol. 2007, 13 (10): 1595-1598.CrossRefPubMedPubMedCentral
34.
Isomoto H, Nakazato M, Ueno H, Date Y, Nishi Y, Mukae H, Mizuta Y, Ohtsuru A, Yamashita S, Kohno S: Low plasma ghrelin levels in patients with Helicobacter pylori-associated gastritis. American Journal of Medicine. 2004, 117 (6): 429-432. 10.1016/j.amjmed.2004.01.030.CrossRefPubMed
35.
Isomoto H, Ueno H, Nishi Y, Wen CY, Nakazato M, Kohno S: Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma. World Journal of Gastroenterology. 2005, 11 (11): 1644-1648.CrossRefPubMedPubMedCentral
36.
Isomoto H, Ueno H, Saenko VA, Mondal MS, Nishi Y, Kawano N, Ohnita K, Mizuta Y, Ohtsuru A, Yamashita S, et al: Impact of Helicobacter pylori infection on gastric and plasma ghrelin dynamics in humans. American Journal of Gastroenterology. 2005, 100 (8): 1711-1720. 10.1111/j.1572-0241.2005.41492.x.CrossRefPubMed
37.
Jun DW, Lee OY, Lee YY, Choi HS, Kim TH, Yoon BC: Correlation between gastrointestinal symptoms and gastric leptin and ghrelin expression in patients with gastritis. Digestive Diseases & Sciences. 2007, 52 (10): 2866-2872. 10.1007/s10620-006-9651-x.CrossRef
38.
Kawashima J, Ohno S, Sakurada T, Takabayashi H, Kudo M, Ro S, Kato S, Yakabi K: Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis. Journal of Gastroenterology. 2009, 44 (10): 1046-1054. 10.1007/s00535-009-0120-0.CrossRefPubMed
39.
Suzuki H, Nishizawa T, Tsuchimoto K, Hibi T: [Helicobacter pylori infected gastric mucosa--inflammation, atrophy and carcinogenesis]. Nippon Saikingaku Zasshi. 2005, 60 (3): 453-457.CrossRefPubMed
40.
Osawa H, Nakazato M, Date Y, Kita H, Ohnishi H, Ueno H, Shiiya T, Satoh K, Ishino Y, Sugano K: Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pylori. Journal of Clinical Endocrinology & Metabolism. 2005, 90 (1): 10-16. 10.1210/jc.2004-1330.CrossRef
41.
Isomoto H, Nishi Y, Ohnita K, Mizuta Y, Kohno S, Ueno H, Nakazato M: The Relationship between Plasma and Gastric Ghrelin Levels and Strain Diversity in Helicobacter pylori Virulence. Am J Gastroenterol. 2005, 100 (6): 1425-1427. 10.1111/j.1572-0241.2005.41929_7.x.CrossRefPubMed
42.
Alonso N, Granada ML, Salinas I, Reverter JL, Flores L, Ojanguren I, Martinez-Caceres EM, Sanmarti A: Plasma ghrelin concentrations in type 1 diabetic patients with autoimmune atrophic gastritis. European Journal of Endocrinology. 2007, 157 (6): 763-769. 10.1530/EJE-07-0300.CrossRefPubMed
43.
Plonka M, Bielanski W, Konturek SJ, Targosz A, Sliwowski Z, Dobrzanska M, Kaminska A, Sito E, Konturek PC, Brzozowski T: Helicobacter pylori infection and serum gastrin, ghrelin and leptin in children of Polish shepherds. Digestive & Liver Disease. 2006, 38 (2): 91-97.
44.
Uzzan B, Catheline JM, Lagorce C, Bon C, Cohen R, Perret GY, Benamouzig R: Expression of ghrelin in fundus is increased after gastric banding in morbidly obese patients. Obesity Surgery. 2007, 17 (9): 1159-1164. 10.1007/s11695-007-9197-9.CrossRefPubMed
45.
Shak JR, Roper J, Perez-Perez GI, Tseng CH, Francois F, Gamagaris Z, Patterson C, Weinshel E, Fielding GA, Ren C, et al: The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormones. Obesity Surgery. 2008, 18 (9): 1089-1096. 10.1007/s11695-008-9454-6.CrossRefPubMedPubMedCentral
46.
Osawa H, Kita H, Ohnishi H, Nakazato M, Date Y, Bowlus CL, Ishino Y, Watanabe E, Shiiya T, Ueno H, et al: Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure. Journal of Gastroenterology. 2006, 41 (10): 954-961. 10.1007/s00535-006-1880-4.CrossRefPubMed
47.
Liew PL, Lee WJ, Lee YC, Chen WY: Gastric ghrelin expression associated with Helicobacter pylori infection and chronic gastritis in obese patients. Obes Surg. 2006, 16 (5): 612-619. 10.1381/096089206776945002.CrossRefPubMed
48.
Tatsuguchi A, Miyake K, Gudis K, Futagami S, Tsukui T, Wada K, Kishida T, Fukuda Y, Sugisaki Y, Sakamoto C: Effect of Helicobacter pylori infection on ghrelin expression in human gastric mucosa. Am J Gastroenterol. 2004, 99 (11): 2121-2127. 10.1111/j.1572-0241.2004.30291.x.CrossRefPubMed
49.
Mendez-Sanchez N, Pichardo-Bahena R, Vasquez-Fernandez F, Lezama-Mora JI, Leon-Canales AL, Barredo-Prieto B, Gonzalez-Avila D, Ponciano-Rodriguez G, Uribe M: Effect of Helicobacter pylori infection on gastric ghrelin expression and body weight. Revista de Gastroenterologia de Mexico. 2007, 72 (4): 359-364.PubMed
50.
Bercik P, Verdu EF, Foster JA, Lu J, Scharringa A, Kean I, Wang L, Blennerhassett P, Collins SM: Role of gut-brain axis in persistent abnormal feeding behavior in mice following eradication of Helicobacter pylori infection. American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 2009, 296 (3): R587-594.CrossRef
51.
Masaoka T, Suzuki H, Imaeda H, Hosoda H, Ohara T, Morishita T, Ishii H, Kangawa K, Hibi T: Long-term strict monitoring of plasma ghrelin and other serological markers of gastric diseases after Helicobacter pylori eradication. Hepato-Gastroenterology. 2005, 52 (61): 1-4.PubMed
52.
Isomoto H, Nishi Y, Ohnita K, Mizuta Y, Kohno S, Ueno H, Nakazato M: The Relationship between Plasma and Gastric Ghrelin Levels and Strain Diversity in Helicobacter pylori Virulence. American Journal of Gastroenterology. 2005, 100 (6): 1425-1427. 10.1111/j.1572-0241.2005.41929_7.x.CrossRefPubMed
53.
Hussein NR, Mohammadi M, Talebkhan Y, Doraghi M, Letley DP, Muhammad MK, Argent RH, Atherton JC: Differences in virulence markers between Helicobacter pylori strains from Iraq and those from Iran: potential importance of regional differences in H. pylori-associated disease. Journal of clinical microbiology. 2008, 46 (5): 1774-1779. 10.1128/JCM.01737-07.CrossRefPubMedPubMedCentral
54.
Suzuki H, Masaoka T, Nomoto Y, Hosoda H, Mori M, Nishizawa T, Minegishi Y, Kangawa K, Hibi T: Increased levels of plasma ghrelin in peptic ulcer disease. Alimentary pharmacology & therapeutics. 2006, 24: 120-126. 10.1111/j.1365-2036.2006.00034.x.CrossRef
55.
Suzuki H, Masaoka T, Hosoda H, Ota T, Minegishi Y, Nomura S, Kangawa K, Ishii H: Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils. Gut. 2004, 53 (2): 187-194. 10.1136/gut.2003.021568.CrossRefPubMedPubMedCentral
56.
Campana D, Nori F, Pagotto U, De Iasio R, Morselli-Labate AM, Pasquali R, Corinaldesi R, Tomassetti P: Plasma acylated ghrelin levels are higher in patients with chronic atrophic gastritis. Clin Endocrinol (Oxf). 2007, 67 (5): 761-766. 10.1111/j.1365-2265.2007.02959.x.CrossRef
57.
Wu MS, Lee WJ, Wang HH, Huang SP, Lin JT: A case-control study of association of Helicobacter pylori infection with morbid obesity in Taiwan. Archives of Internal Medicine. 2005, 165 (13): 1552-1555. 10.1001/archinte.165.13.1552.CrossRefPubMed
58.
Shinomiya T, Fukunaga M, Akamizu T, Irako T, Yokode M, Kangawa K, Nakai Y, Nakai Y: Plasma acylated ghrelin levels correlate with subjective symptoms of functional dyspepsia in female patients. Scandinavian Journal of Gastroenterology. 2005, 40 (6): 648-653. 10.1080/00365520510015403.CrossRefPubMed
59.
Suzuki H, Masaoka T, Sakai G, Ishii H, Hibi T: Improvement of gastrointestinal quality of life scores in cases of Helicobacter pylori-positive functional dyspepsia after successful eradication therapy. Journal of gastroenterology and hepatology. 2005, 20 (11): 1652-1660. 10.1111/j.1440-1746.2005.04039.x.CrossRefPubMed
60.
Sundbom M, Holdstock C, Engstrom E, Karlsson FA: Early changes in ghrelin following Roux-en-Y gastric bypass: Influence of vagal nerve functionality?. Obesity Surgery. 2007, 17 (3): 304-310. 10.1007/s11695-007-9056-8.CrossRefPubMed
61.
Huang Q, Fan YZ, Ge BJ, Zhu Q, Tu ZY: Circulating ghrelin in patients with gastric or colorectal cancer. Digestive diseases and sciences. 2007, 52 (3): 803-809. 10.1007/s10620-006-9508-3.CrossRefPubMed
62.
Nishizawa T, Suzuki H, Nomoto Y, Masaoka T, Hosoda H, Mori M, Ohara T, Morishita T, Kangawa K, Hibi T: Enhanced plasma ghrelin levels in patients with functional dyspepsia. Alimentary Pharmacology & Therapeutics. 2006, 24: 104-110. 10.1111/j.1365-2036.2006.00032.x.CrossRef
63.
Ando T, Minami M, Ishiguro K, Maeda O, Watanabe O, Mizuno T, Fujita T, Takahashi H, Noshiro M, Goto H: Changes in biochemical parameters related to atherosclerosis after Helicobacter pylori eradication. Alimentary Pharmacology & Therapeutics. 2006, 24: 58-64. 10.1111/j.1365-2036.2006.00026.x.CrossRef
64.
Kempa A, Krzyzanowska-Swiniarska B, Miazgowski T, Pilarska K: Not insulin but insulin sensivity, leptin, and cortisol are major factors regulating serum acylated ghrelin level in healthy women. Journal of Endocrinological Investigation. 2007, 30: 659-665.CrossRefPubMed
65.
Ates Y, Degertekin B, Erdil A, Yaman H, Dagalp K: Serum ghrelin levels in inflammatory bowel disease with relation to disease activity and nutritional status. Digestive diseases and sciences. 2008, 53 (8): 2215-2221. 10.1007/s10620-007-0113-x.CrossRefPubMed
66.
Wang HH, Lee WJ, Liew PL, Yang CS, Liang RJ, Wang W, Lin JT, Wu MS: The influence of Helicobacter pylori infection and corpus gastritis on the postoperative outcomes of laparoscopic vertical banded gastroplasty. Obesity Surgery. 2006, 16 (3): 297-307. 10.1381/096089206776116417.CrossRefPubMed
67.
Doki Y, Takachi K, Ishikawa O, Miyashiro I, Sasaki Y, Ohigashi H, Nakajima H, Hosoda H, Kangawa K, Sasakuma F, et al: Ghrelin reduction after esophageal substitution and its correlation to postoperative body weight loss in esophageal cancer patients. Surgery. 2006, 139 (6): 797-805. 10.1016/j.surg.2005.11.015.CrossRefPubMed
68.
Gao XY, Kuang HY, Liu XM, Ma ZB, Nie HJ, Guo H: Plasma obestatin levels in men with chronic atrophic gastritis. Peptides. 2008, 29 (10): 1749-1754. 10.1016/j.peptides.2008.05.027.CrossRefPubMed
69.
Cherian S, Forbes D, Sanfilippo F, Cook A, Burgner D: Helicobacter pylori, helminth infections and growth: a cross-sectional study in a high prevalence population. Acta Paediatrica. 2009, 98 (5): 860-864. 10.1111/j.1651-2227.2009.01221.x.CrossRefPubMed
70.
Kebapcilar L, Sari I, Renkal AH, Alacacioglu A, Yuksel A, Ilhan E, Alkan B, Yuksel D, Kozaci DL, Gunay N: The Influence of Helicobacter pylori Eradication on Leptin, Soluble CD40 Ligand, Oxidative Stress and Body Composition in Patients with Peptic Ulcer Disease. Internal Medicine. 2009, 48 (24): 2055-2059. 10.2169/internalmedicine.48.2562.CrossRefPubMed
71.
Dutta SK, Arora M, Kireet A, Bashandy H, Gandsas A: Upper Gastrointestinal Symptoms and Associated Disorders in Morbidly Obese Patients: A Prospective Study. Digestive Diseases and Sciences. 2009, 54 (6): 1243-1246. 10.1007/s10620-008-0485-6.CrossRefPubMed
72.
Gen R, Demir M, Ataseven H: Effect of Helicobacter pylori Eradication on Insulin Resistance, Serum Lipids and Low-Grade Inflammation. Southern Medical Journal. 2010, 103 (3): 190-196.CrossRefPubMed
Metadata
Title
Helicobacter pylori infection and circulating ghrelin levels - A systematic review
Authors
Chidi V Nweneka
Andrew M Prentice
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2011
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/1471-230X-11-7

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