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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2007

Open Access 01-12-2007 | Research

Helicobacter pylori in colorectal neoplasms: is there an aetiological relationship?

Authors: Mary Jones, Peter Helliwell, Colin Pritchard, Joseph Tharakan, Joseph Mathew

Published in: World Journal of Surgical Oncology | Issue 1/2007

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Abstract

Background

This pilot study was carried out to determine whether Helicobacter pylori can be detected in normal colon or in association with colorectal neoplasia.

Methods

Paraffin processed colonic tissue blocks of normal colonic mucosa (n = 60), and patients diagnosed as adenoma (n = 60), and adenocarcinoma (n = 60) were retrieved from our archive; the adenoma group included tubular (n = 20), tubulovillous (n = 20) and villous adenomas (n = 20). 4 μm sections were stained by immunohistochemical methods using anti-Helicobacter pylori antibodies (polyclonal NCL-HPp and monoclonal NCL-C-jejuni).

Results

Significant numbers of Helicobacter pylori were identified in tubular adenomas (OR = 11.13; 95%CI = 1.62–76.70), tubulovillous adenomas (OR = 10.45; 95%CI = 1.52–71.52) and adenocarcinomas (OR = 8.13; 95%CI = 1.40–46.99) compared to controls: there was no association in numbers of Helicobacter pylori and villous adenomas (OR = 2.95; 95%CI = 0.29–9.96).

Conclusion

We conclude that although, in this pilot study, there appears to be an association in the prevalence of Helicobacter pylori with some, but not all, colorectal neoplasms, we can not infer causality from these results. These findings need to be further substantiated with a prospective study and the use of molecular biological techniques to determine a causal association.
Appendix
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Metadata
Title
Helicobacter pylori in colorectal neoplasms: is there an aetiological relationship?
Authors
Mary Jones
Peter Helliwell
Colin Pritchard
Joseph Tharakan
Joseph Mathew
Publication date
01-12-2007
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2007
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-5-51

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