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01-01-2022 | Heart Surgery | Systematic Review/Meta-analysis

Biomarkers of acute kidney injury in pediatric cardiac surgery

Authors: Candice Torres de Melo Bezerra Cavalcante, Marcelo Borges Cavalcante, Klebia Magalhães Pereira Castello Branco, Titus Chan, Isabel Cristina Leite Maia, Ronald Guedes Pompeu, Andrea Consuelo de Oliveira Telles, Anna Karina Martins Brito, Alexandre Braga Libório

Published in: Pediatric Nephrology | Issue 1/2022

Abstract

Acute kidney injury (AKI) is characterized by a sudden decrease in kidney function. Children with congenital heart disease are a special group at risk of developing AKI. We performed a systematic review of the literature to search for studies reporting the usefulness of novel urine, serum, and plasma biomarkers in the diagnosis and progression of AKI and their association with clinical outcomes in children undergoing pediatric cardiac surgery. In thirty studies, we analyzed the capacity to predict AKI and poor outcomes of five biomarkers: Cystatin C, Neutrophil gelatinase-associated lipocalin, Interleukin-18, Kidney injury molecule-1, and Liver fatty acid–binding protein. In conclusion, we suggest the need for further meta-analyses with the availability of additional studies.

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Title: Biomarkers of acute kidney injury in pediatric cardiac surgery
Authors: Candice Torres de Melo Bezerra Cavalcante
Marcelo Borges Cavalcante
Klebia Magalhães Pereira Castello Branco
Titus Chan
Isabel Cristina Leite Maia
Ronald Guedes Pompeu
Andrea Consuelo de Oliveira Telles
Anna Karina Martins Brito
Alexandre Braga Libório
Publication date: 01-01-2022
Publisher: Springer Berlin Heidelberg
Keywords: Heart Surgery
Acute Kidney Injury
Heart Surgery
Pediatric Cardiac Surgery
Acute Kidney Injury
Biomarkers
Published in: Pediatric Nephrology / Issue 1/2022
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-021-05094-9

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Biomarkers of acute kidney injury in pediatric cardiac surgery

Abstract

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Abstract

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