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Current Heart Failure Reports
Published in: Current Heart Failure Reports 3/2024

20-03-2024 | Heart Failure | Review

Pregnancy, Reproductive Factors, and Female Heart Failure Risk and Outcomes

Authors: Guillermo Moreno, Manuel Martínez-Sellés, María Jesús Vicente-Galán, Lourdes Vicent

Published in: Current Heart Failure Reports | Issue 3/2024

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Abstract

Purpose of Review

The purpose of this review is to provide an overview of recent evidence on female-specific risk factors related to reproductive status or pregnancy.

Recent Findings

Pregnancy-related factors, including hypertensive disorders and gestational diabetes, increase the risk of heart failure in women, while breastfeeding and hormone therapy may offer protection.

Summary

Hypertensive disorders of pregnancy, gestational diabetes, polycystic ovarian syndrome, placental abruption, younger maternal age at first live birth, younger maternal age at last live birth, number of stillbirths, number of pregnancies, onset of menstruation before 12 years of age, shorter reproductive age, ovariectomy, and prolonged absence of ovarian hormones may increase the risk of heart failure in women. Conversely, breastfeeding status and hormone therapy (for menopause or contraception) may serve as protective factors, while fertility treatments have no discernible effect on the risk of heart failure.
Literature
1.
2.
Pelliccia F, Limongelli G, Autore C, Gimeno-Blanes JR, Basso C, Elliott P. Sex-related differences in cardiomyopathies. Int J Cardiol. 2019;286:239–43.PubMedCrossRef
3.
van der Kemp J, van der Schouw YT, Asselbergs FW, Onland-Moret NC. Women-specific risk factors for heart failure: a genetic approach. Maturitas. 2018;109:104–11.PubMedCrossRef
4.
Chen M, Wang Z, Xu H, Chen X, Teng P, Ma L. Genetic liability to age at first sex and birth in relation to cardiovascular diseases: a Mendelian randomization study. BMC Med Genomics. 2023;16(1):75.PubMedPubMedCentralCrossRef
5.
• Zhu F, Qi H, Bos M, Boersma E, Kavousi M. Female reproductive factors and risk of new-onset heart failure: findings from UK Biobank. JACC Heart Fail. 2023;11(9):1203–12. (This study, a new and unique contribution from the UK Biobank, examines the association between various reproductive factors in women and the risk of heart failure.)PubMedCrossRef
6.
Ardissino M, Slob EAW, Carter P, Rogne T, Girling J, Burgess S, et al. Sex-specific reproductive factors augment cardiovascular disease risk in women: a Mendelian randomization study. J Am Heart Assoc. 2023;12(5): e027933.PubMedPubMedCentralCrossRef
7.
Lau ES, Wang D, Roberts M, Taylor CN, Murugappan G, Shadyab AH, et al. Infertility and risk of heart failure in the women’s health initiative. J Am Coll Cardiol. 2022;79(16):1594–603.PubMedPubMedCentralCrossRef
8.
Martínez-Sellés M, Díez-Villanueva P, Álvarez Garcia J, Ferrero-Gregori A, Vives-Borrás M, Worner F, et al. Influence of sex and pregnancy on survival in patients admitted with heart failure: data from a prospective multicenter registry. Clin Cardiol. 2018;41(7):924–30.PubMedPubMedCentralCrossRef
9.
10.
Martínez-Sellés M, Doughty RN, Poppe K, Whalley GA, Earle N, Tribouilloy C, et al. Gender and survival in patients with heart failure: interactions with diabetes and aetiology. Results from the MAGGIC individual patient meta-analysis. Eur J Heart Fail. 2012;14(5):473–9.PubMedCrossRef
11.
12.
Martínez-Sellés M, García Robles JA, Prieto L, Domínguez Muñoa M, Frades E, Díaz-Castro O, et al. Systolic dysfunction is a predictor of long term mortality in men but not in women with heart failure. Eur Heart J. 2003;24(22):2046–53.PubMedCrossRef
13.
Santas E, Palau P, Llácer P, de la Espriella R, Miñana G, Núñez-Marín G, et al. Sex-related differences in mortality following admission for acute heart failure across the left ventricular ejection fraction spectrum. J Am Heart Assoc. 2022;11(1): e022404.PubMedCrossRef
14.
Bayes-Genis A, Bellosillo B, de la Calle O, Salido M, Roura S, Ristol FS, et al. Identification of male cardiomyocytes of extracardiac origin in the hearts of women with male progeny: male fetal cell microchimerism of the heart. J Hear lung Transplant Off Publ Int Soc Hear Transplant. 2005;24(12):2179–83.CrossRef
15.
16.
17.
Martínez-Sellés M, Pérez-David E, Yotti R, Jiménez-Borreguero J, Loughlin G, Gallego L, et al. Gender differences in right ventricular function in patients with non-ischaemic cardiomyopathy. Netherlands Hear J Mon J Netherlands Soc Cardiol Netherlands Hear Found. 2015;23(12):578–84.CrossRef
18.
• Mantel Ä, Sandström A, Faxén J, Andersson DC, Razaz N, Cnattingius S, et al. Pregnancy-induced hypertensive disorder and risks of future ischemic and nonischemic heart failure. JACC Heart Fail. 2023;11(9):1216–28. (This study evaluates the association between pregnancy-induced hypertensive disorders and heart failure risk, distinguishing between ischemic and non-ischemic subtypes. It also examines the effect of disease characteristics and the timing of heart failure risk.)PubMedCrossRef
19.
Honigberg MC, Zekavat SM, Aragam K, Klarin D, Bhatt DL, Scott NS, et al. Long-term cardiovascular risk in women with hypertension during pregnancy. J Am Coll Cardiol. 2019;74(22):2743–54.PubMedPubMedCentralCrossRef
20.
Countouris ME, Villanueva FS, Berlacher KL, Cavalcante JL, Parks WT, Catov JM. Association of hypertensive disorders of pregnancy with left ventricular remodeling later in life. J Am Coll Cardiol. 2021;77(8):1057–68.PubMedPubMedCentralCrossRef
21.
22.
deMartelly VA, Dreixler J, Tung A, Mueller A, Heimberger S, Fazal AA, et al. Long-term postpartum cardiac function and its association with preeclampsia. J Am Heart Assoc. 2021;10(5): e018526.PubMedPubMedCentralCrossRef
23.
Leon LJ, McCarthy FP, Direk K, Gonzalez-Izquierdo A, Prieto-Merino D, Casas JP, et al. Preeclampsia and cardiovascular disease in a large UK pregnancy cohort of linked electronic health records: a CALIBER study. Circulation. 2019;140(13):1050–60.PubMedCrossRef
24.
Williams D, Stout MJ, Rosenbloom JI, Olsen MA, Joynt Maddox KE, Deych E, et al. Preeclampsia predicts risk of hospitalization for heart failure with preserved ejection fraction. J Am Coll Cardiol. 2021;78(23):2281–90.PubMedPubMedCentralCrossRef
25.
Lee SM, Shivakumar M, Park JW, Jung YM, Choe EK, Kwak SH, et al. Long-term cardiovascular outcomes of gestational diabetes mellitus: a prospective UK Biobank study. Cardiovasc Diabetol. 2022;21(1):221.PubMedPubMedCentralCrossRef
26.
Christensen MH, Rubin KH, Petersen TG, Nohr EA, Vinter CA, Andersen MS, et al. Cardiovascular and metabolic morbidity in women with previous gestational diabetes mellitus: a nationwide register-based cohort study. Cardiovasc Diabetol. 2022;21(1):179.PubMedPubMedCentralCrossRef
27.
Company Calabuig AM, Nunez E, Sánchez A, Nicolaides KH, Charakida M, De Paco MC. Three-dimensional echocardiography and cardiac strain imaging in women with gestational diabetes mellitus. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol. 2021;58(2):278–84.CrossRef
28.
Retnakaran R, Shah BR. Mediating effect of vascular risk factors underlying the link between gestational diabetes and cardiovascular disease. BMC Med. 2022;20(1):389.PubMedPubMedCentralCrossRef
29.
30.
Chen S-N, Cheng C-C, Tsui K-H, Tang P-L, Chern C-U, Huang W-C, et al. Hypertensive disorders of pregnancy and future heart failure risk: a nationwide population-based retrospective cohort study. Pregnancy Hypertens. 2018;13:110–5.PubMedCrossRef
31.
Honigberg MC, Riise HKR, Daltveit AK, Tell GS, Sulo G, Igland J, et al. Heart failure in women with hypertensive disorders of pregnancy: insights from the cardiovascular disease in Norway project. Hypertens (Dallas, Tex 1979). 2020;76(5):1506–13.CrossRef
32.
33.
DesJardin JT, Healy MJ, Nah G, Vittinghoff E, Agarwal A, Marcus GM, et al. Placental abruption as a risk factor for heart failure. Am J Cardiol. 2020;131:17–22.PubMedCrossRef
34.
Crump C, Sundquist J, Howell EA, McLaughlin MA, Stroustrup A, Sundquist K. Pre-term delivery and risk of ischemic heart disease in women. J Am Coll Cardiol. 2020;76(1):57–67.PubMedPubMedCentralCrossRef
35.
Davis MB, Arany Z, McNamara DM, Goland S, Elkayam U. Peripartum cardiomyopathy: JACC state-of-the-art review. J Am Coll Cardiol. 2020;75(2):207–21.PubMedCrossRef
36.
McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599–726.PubMedCrossRef
37.
38.
39.
Sliwa K, Bauersachs J, Arany Z, Spracklen TF, Hilfiker-Kleiner D. Peripartum cardiomyopathy: from genetics to management. Eur Heart J. 2021;42(32):3094–102.PubMedCrossRef
40.
• Jackson AM, Petrie MC, Frogoudaki A, Laroche C, Gustafsson F, Ibrahim B, et al. Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry. Eur J Heart Fail. 2021;23(12):2058–69. (This study describes variations in phenotype and outcomes among women with peripartum cardiomyopathy (PPCM), comparing those with and without hypertensive disorders during pregnancy.)PubMedCrossRef
41.
Bauersachs J, König T, van der Meer P, Petrie MC, Hilfiker-Kleiner D, Mbakwem A, et al. Pathophysiology, diagnosis and management of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy. Eur J Heart Fail. 2019;21(7):827–43.PubMedCrossRef
42.
Sliwa K, Petrie MC, Hilfiker-Kleiner D, Mebazaa A, Jackson A, Johnson MR, et al. Long-term prognosis, subsequent pregnancy, contraception and overall management of peripartum cardiomyopathy: practical guidance paper from the Heart Failure Association of the European Society of Cardiology Study Group on Peripartum Cardiomyopathy. Eur J Heart Fail. 2018;20(6):951–62.PubMedCrossRef
43.
Karaye KM, Sa’idu H, Balarabe SA, Ishaq NA, Adamu UG, Mohammed IY, et al. Clinical features and outcomes of peripartum cardiomyopathy in Nigeria. J Am Coll Cardiol. 2020;76(20):2352–64.PubMedCrossRef
44.
Duncker D, Westenfeld R, Konrad T, Pfeffer T, Correia de Freitas CA, Pfister R, et al. Risk for life-threatening arrhythmia in newly diagnosed peripartum cardiomyopathy with low ejection fraction: a German multi-centre analysis. Clin Res Cardiol. 2017;106(8):582–9.PubMedPubMedCentralCrossRef
45.
Goland S, George J, Elkayam U, Shimoni S, Fugenfirov I, Vaisbuch E, et al. Contemporary outcome of subsequent pregnancies in patients with previous peripartum cardiomyopathy. ESC Hear Fail. 2022;9(6):4262–70.CrossRef
46.
Abu-Zaid A, Gari A, Alsharif SA, Alshahrani MS, Khadawardi K, Ahmed AM, et al. Exploring the impact of chronic medical conditions on maternal mental health: a national inpatient sample analysis. Eur J Obstet Gynecol Reprod Biol. 2023;289:42–7.PubMedCrossRef
47.
Pfeffer TJ, Herrmann J, Berliner D, König T, Winter L, Ricke-Hoch M, et al. Assessment of major mental disorders in a German peripartum cardiomyopathy cohort. ESC Hear Fail. 2020;7(6):4394–8.CrossRef
48.
Udemgba C, Bravo-Jaimes K, Mejia MO, Oli PR, Shrestha DB, Dawadi S, et al. Differences in clinical presentation and outcomes in pregnancy-associated takotsubo - a scoping review of the literature: outcomes in pregnancy-associated Takotsubo. Curr Probl Cardiol. 2023 Oct;102175. https://​doi.​org/​10.​1016/​j.​cpcardiol.​2023.​102175.
49.
Singh T, Mishra AK, Vojjala N, John KJ, George AA, Jha A, et al. Cardiovascular complications following medical termination of pregnancy: an updated review. World J Cardiol. 2023;15(10):518–30.PubMedPubMedCentralCrossRef
50.
Mogos MF, Ahn S, Muchira JM, Osmundson S, Piano MR. Pregnancy-associated takotsubo cardiomyopathy hospitalizations in the United States. Am J Physiol Heart Circ Physiol. 2023;325(3):H468–74.PubMedCrossRef
51.
Plompen MVL, van der Schouw YT, Rutten FH, Verschuren WMM, Boer JMA, Asselbergs FW, et al. Age at menarche and heart failure risk: the EPIC-NL study. Maturitas. 2020;131:34–9.PubMedCrossRef
52.
Zhao D, Guallar E, Ballantyne CM, Post WS, Ouyang P, Vaidya D, et al. Sex hormones and incident heart failure in men and postmenopausal women: the atherosclerosis risk in communities study. J Clin Endocrinol Metab. 2020;105(10):e3798–807.PubMedPubMedCentralCrossRef
53.
Willemars MMA, Nabben M, Verdonschot JAJ, Hoes MF. Evaluation of the interaction of sex hormones and cardiovascular function and health. Curr Heart Fail Rep. 2022;19(4):200–12.PubMedPubMedCentralCrossRef
54.
Udell JA, Lu H, Redelmeier DA. Failure of fertility therapy and subsequent adverse cardiovascular events. C Can Med Assoc J = J l’Association medicale Can. 2017;189(10):E391-7.CrossRef
55.
Dayan N, Filion KB, Okano M, Kilmartin C, Reinblatt S, Landry T, et al. Cardiovascular risk following fertility therapy: systematic review and meta-analysis. J Am Coll Cardiol. 2017;70(10):1203–13.PubMedCrossRef
56.
Magnus MC, Fraser A, Håberg SE, Rönö K, Romundstad LB, Bergh C, et al. Maternal risk of cardiovascular disease after use of assisted reproductive technologies. JAMA Cardiol. 2023;8(9):837–45.PubMedPubMedCentralCrossRef
57.
Dou W, Huang Y, Liu X, Huang C, Huang J, Xu B, et al. Associations of oral contraceptive use with cardiovascular disease and all-cause death: evidence from the UK Biobank Cohort Study. J Am Heart Assoc. 2023;12(16): e030105.PubMedPubMedCentralCrossRef
58.
Luo D, Li H, Chen P, Xie N, Yang Z, Zhang C. Association between oral contraceptive use and incident heart failure. ESC Hear Fail. 2021;8(3):2282–92.CrossRef
59.
Alur-Gupta S, Boland MR, Barnhart KT, Sammel MD, Dokras A. Postpartum complications increased in women with polycystic ovary syndrome. Am J Obstet Gynecol. 2021;224(3):280.e1-280.e13.PubMedCrossRef
60.
Zahid S, Khan MZ, Gowda S, Faza NN, Honigberg MC, Vaught AJ, et al. Trends, predictors, and outcomes of cardiovascular complications associated with polycystic ovary syndrome during delivery hospitalizations: a national inpatient sample analysis (2002–2019). J Am Heart Assoc. 2022;11(16): e025839.PubMedPubMedCentralCrossRef
61.
Zhang X, Huangfu Z, Wang S. No association effect of genetic polymorphism was observed between polycystic ovary syndrome and cardiovascular diseases risk: a mendelian randomization study. Endocrine. 2023;82(3):695–706.PubMedCrossRef
62.
Wekker V, van Dammen L, Koning A, Heida KY, Painter RC, Limpens J, et al. Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis. Hum Reprod Update. 2020;26(6):942–60.PubMedPubMedCentralCrossRef
63.
Ramezani Tehrani F, Amiri M, Behboudi-Gandevani S, Bidhendi-Yarandi R, Carmina E. Cardiovascular events among reproductive and menopausal age women with polycystic ovary syndrome: a systematic review and meta-analysis. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol. 2020;36(1):12–23.CrossRef
64.
Ollila M-M, Arffman RK, Korhonen E, Morin-Papunen L, Franks S, Junttila J, et al. Women with PCOS have an increased risk for cardiovascular disease regardless of diagnostic criteria-a prospective population-based cohort study. Eur J Endocrinol. 2023;189(1):96–105.PubMedCrossRef
65.
De Jong KA, Berisha F, Naderpoor N, Appelbe A, Kotowicz MA, Cukier K, et al. Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women. PLoS ONE. 2022;17(2): e0263312.PubMedPubMedCentralCrossRef
66.
Parikh NI, Gonzalez JM, Anderson CAM, Judd SE, Rexrode KM, Hlatky MA, et al. Adverse pregnancy outcomes and cardiovascular disease risk: unique opportunities for cardiovascular disease prevention in women: a scientific statement from the American Heart Association. Circulation. 2021;143(18):e902–16.PubMedCrossRef
67.
68.
Bonifacino E, Schwartz EB, Jun H, Wessel CB, Corbelli JA. Effect of lactation on maternal hypertension: a systematic review. Breastfeed Med Off J Acad Breastfeed Med. 2018;13(9):578–88.CrossRef
69.
Qu G, Wang L, Tang X, Wu W, Sun Y. Association between duration of breastfeeding and maternal hypertension: a systematic review and meta-analysis. Breastfeed Med Off J Acad Breastfeed Med. 2018;13(5):318–26.CrossRef
70.
Kirkegaard H, Bliddal M, Støvring H, Rasmussen KM, Gunderson EP, Køber L, et al. Breastfeeding and later maternal risk of hypertension and cardiovascular disease - the role of overall and abdominal obesity. Prev Med (Baltim). 2018;114:140–8.CrossRef
71.
Gunderson EP, Lewis CE, Lin Y, Sorel M, Gross M, Sidney S, et al. Lactation duration and progression to diabetes in women across the childbearing years: the 30-year CARDIA study. JAMA Intern Med. 2018;178(3):328–37.PubMedPubMedCentralCrossRef
72.
Peters SAE, Yang L, Guo Y, Chen Y, Bian Z, Du J, et al. Breastfeeding and the risk of maternal cardiovascular disease: a prospective study of 300 000 Chinese women. J Am Heart Assoc. 2017;6(6):e006081.
73.
Nguyen B, Gale J, Nassar N, Bauman A, Joshy G, Ding D. Breastfeeding and cardiovascular disease hospitalization and mortality in parous women: evidence from a large Australian cohort study. J Am Heart Assoc. 2019;8(6): e011056.PubMedPubMedCentralCrossRef
74.
Yu J, Pudwell J, Dayan N, Smith GN. Postpartum breastfeeding and cardiovascular risk assessment in women following pregnancy complications. J Womens Health (Larchmt). 2020;29(5):627–35.PubMedCrossRef
75.
Koczo A, Marino A, Jeyabalan A, Elkayam U, Cooper LT, Fett J, et al. Breastfeeding, cellular immune activation, and myocardial recovery in peripartum cardiomyopathy. JACC Basic to Transl Sci. 2019;4(3):291–300.CrossRef
76.
Martínez-Solano J, Martínez-Sellés M. Sudden death in men versus women with heart failure. Curr Heart Fail Rep. 2023;20(2):129–37.PubMedCrossRef
77.
Huang C-H, Kor C-T, Lian I-B, Chang C-C. Menopausal symptoms and risk of heart failure: a retrospective analysis from Taiwan National Health Insurance Database. ESC Hear Fail. 2021;8(4):3295–307.CrossRef
78.
Liu J, Jin X, Chen W, Wang L, Feng Z, Huang J. Early menopause is associated with increased risk of heart failure and atrial fibrillation: a systematic review and meta-analysis. Maturitas. 2023;176: 107784.PubMedCrossRef
79.
Ramirez MF, Honigberg M, Wang D, Parekh JK, Bielawski K, Courchesne P, et al. Protein biomarkers of early menopause and incident cardiovascular disease. J Am Heart Assoc. 2023;12(16): e028849.PubMedPubMedCentralCrossRef
80.
Ebong IA, Wilson MD, Chang P, Appiah D, Polonsky T, Ballantyne C, et al. NT-pro B-type natriuretic peptide, early menopause, and incident heart failure in postmenopausal women of the ARIC study. Menopause. 2022;29(3):309–16.PubMedCrossRef
81.
Ebong IA, Wilson MD, Appiah D, Michos ED, Racette SB, Villablanca A, et al. Relationship between age at menopause, obesity, and incident heart failure: the atherosclerosis risk in communities study. J Am Heart Assoc. 2022;11(8): e024461.PubMedPubMedCentralCrossRef
82.
83.
Díez-Villanueva P, Jiménez-Méndez C, López-Lluva MT, Wasniewski S, Solís J, Fernández-Friera L, et al. Heart failure in the elderly: the role of biological and sociocultural aspects related to sex. Curr Heart Fail Rep. 2023;20(5):321–32.PubMedCrossRef
84.
Arafa A, Kashima R, Kokubo Y, Teramoto M, Sakai Y, Nosaka S, et al. Serum cholesterol levels and the risk of brain natriuretic peptide-diagnosed heart failure in postmenopausal women: a population-based prospective cohort study. Menopause. 2023;30(8):831–8.PubMedCrossRef
85.
Baig M, Moafi-Madani M, Qureshi R, Roberts MB, Allison M, Manson JE, et al. Heart rate variability and the risk of heart failure and its subtypes in post-menopausal women: the Women’s Health Initiative study. PLoS ONE. 2022;17(10): e0276585.PubMedPubMedCentralCrossRef
86.
Sung K-T, Chandramouli C, Lo C-I, Tsai J-P, Lai Y-H, Hsiao C-C, et al. Association of female menopause with atrioventricular mechanics and outcomes. Front Cardiovasc Med. 2022;9: 804336.PubMedPubMedCentralCrossRef
87.
88.
Díez-Villanueva P, Jiménez-Méndez C, Bonanad C, Ortiz-Cortés C, Barge-Caballero E, Goirigolzarri J, et al. Sex differences in the impact of frailty in elderly outpatients with heart failure. Front Cardiovasc Med. 2022;9:1000700.PubMedPubMedCentralCrossRef
89.
Hansen AL, Søndergaard MM, Hlatky MA, Vittinghof E, Nah G, Stefanick ML, et al. Adverse pregnancy outcomes and incident heart failure in the Women’s Health Initiative. JAMA Netw open. 2021;4(12): e2138071.PubMedPubMedCentralCrossRef
90.
91.
Liu L, Klein L, Eaton C, Panjrath G, Martin LW, Chae CU, et al. Menopausal hormone therapy and risks of first hospitalized heart failure and its subtypes during the intervention and extended postintervention follow-up of the Women’s Health Initiative randomized trials. J Card Fail. 2020;26(1):2–12.PubMedCrossRef
92.
Oliver-Williams C, Glisic M, Shahzad S, Brown E, Pellegrino Baena C, Chadni M, et al. The route of administration, timing, duration and dose of postmenopausal hormone therapy and cardiovascular outcomes in women: a systematic review. Hum Reprod Update. 2019;25(2):257–71.PubMedCrossRef
93.
Qian C, Liu J, Liu H. Targeting estrogen receptor signaling for treating heart failure. Heart Fail Rev. 2024;29(1):125–131.
94.
Firth JM, Yang H-Y, Francis AJ, Islam N, MacLeod KT. The effect of estrogen on intracellular Ca(2+) and Na(+) regulation in heart failure. JACC Basic to Transl Sci. 2020;5(9):901–12.CrossRef
Metadata
Title
Pregnancy, Reproductive Factors, and Female Heart Failure Risk and Outcomes
Authors
Guillermo Moreno
Manuel Martínez-Sellés
María Jesús Vicente-Galán
Lourdes Vicent
Publication date
20-03-2024
Publisher
Springer US
Published in
Current Heart Failure Reports / Issue 3/2024
Print ISSN: 1546-9530
Electronic ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-024-00657-x

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

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Prof. Florian Limbourg
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