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Published in: Current Heart Failure Reports 6/2019

01-12-2019 | Heart Failure | Decompensated Heart Failure (P Banerjee, Section Editor)

Patient-Associated Predictors of 15- and 30-Day Readmission After Hospitalization for Acute Heart Failure

Authors: Juan F. Delgado, Andreu Ferrero Gregori, Laura Morán Fernández, Ramón Bascompte Claret, Andrés Grau Sepúlveda, Francisco Fernández-Avilés, José R. González-Juanatey, Rafael Vázquez García, Miguel Rivera Otero, Javier Segovia Cubero, Domingo Pascual Figal, Maria G. Crespo-Leiro, Jesús Alvarez-García, Juan Cinca, Fernando Arribas Ynsaurriaga

Published in: Current Heart Failure Reports | Issue 6/2019

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Abstract

Background

Identifying readmission predictors in heart failure (HF) patients may help guide preventative efforts and save costs. We aimed to identify 15- and 30-day readmission predictors due to cardiovascular reasons.

Methods and Results

A total of 1831 patients with acute HF admission were prospectively followed during a year. Patient-associated variables were gathered at admission/discharge and events during follow-up. A multivariate Fine and Gray competing risk regression model and a cumulative incidence function were used to identify predictors and build a risk score model for 15- and 30-day readmission. The 15- and 30-day readmission rates due to cardiovascular reasons were 7.1% and 13.9%. Previous acute myocardial infarction, congestive signs at discharge, and length of stay > 9 days were predictors of 15- and 30-day readmission, while much weight loss and large NT-ProBNP reduction were protective factors. The NT-ProBNP reduction was larger at 30 days (> 55%) vs 15 days (> 40%) to protect from readmission. Glomerular filtration rate at discharge < 60 mL/min/1.73m2 and > 1 previous admissions due to HF were predictors of 30-day readmission, while first post-discharge control at an HF unit was a protective factor.

Conclusions

Previous identified factors for early readmission were confirmed. The NT-ProBNP reduction should be increased (> 55%) to protect from 30-day readmission.
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Literature
7.
go back to reference •• Dharmarajan K, Hsieh AF, Lin Z, Bueno H, Ross JS, Horwitz LI, et al. Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia. JAMA. 2013;309(4):355–63. https://doi.org/10.1001/jama.2012.216476This study evaluated more than 1 million US patients (Medicare beneficiaries) who had been hospitalized for heart failure; more specifically, it investigated the percentage of rehospitalization after 1 month, which was determined to be up to 25%. It is important to our study due to paper's scope, high number of patients, overall results and general relevance. CrossRefPubMedPubMedCentral •• Dharmarajan K, Hsieh AF, Lin Z, Bueno H, Ross JS, Horwitz LI, et al. Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia. JAMA. 2013;309(4):355–63. https://​doi.​org/​10.​1001/​jama.​2012.​216476This study evaluated more than 1 million US patients (Medicare beneficiaries) who had been hospitalized for heart failure; more specifically, it investigated the percentage of rehospitalization after 1 month, which was determined to be up to 25%. It is important to our study due to paper's scope, high number of patients, overall results and general relevance. CrossRefPubMedPubMedCentral
9.
go back to reference Pandolfi MM, Wang Y, Spenard A, Johnson F, Bonner A, Ho SY, et al. Associations between nursing home performance and hospital 30-day readmissions for acute myocardial infarction, heart failure and pneumonia at the healthcare community level in the United States. Int J Older People Nursing. 2017. https://doi.org/10.1111/opn.12154.CrossRef Pandolfi MM, Wang Y, Spenard A, Johnson F, Bonner A, Ho SY, et al. Associations between nursing home performance and hospital 30-day readmissions for acute myocardial infarction, heart failure and pneumonia at the healthcare community level in the United States. Int J Older People Nursing. 2017. https://​doi.​org/​10.​1111/​opn.​12154.CrossRef
11.
go back to reference McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012;33(14):1787–847. https://doi.org/10.1093/eurheartj/ehs104.CrossRefPubMed McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012;33(14):1787–847. https://​doi.​org/​10.​1093/​eurheartj/​ehs104.CrossRefPubMed
15.
go back to reference • Minana G, Bosch MJ, Nunez E, Mollar A, Santas E, Valero E, et al. Length of stay and risk of very early readmission in acute heart failure. Eur J Intern Med. 2017;42:61–6. https://doi.org/10.1016/j.ejim.2017.04.003This study, carried out in Spain, evaluated 2110 consecutive patients who had been discharged after being hospitalized for heart failure. The paper established the percentage of rehospitalizations/month, which was deemed to be 13%. CrossRefPubMed • Minana G, Bosch MJ, Nunez E, Mollar A, Santas E, Valero E, et al. Length of stay and risk of very early readmission in acute heart failure. Eur J Intern Med. 2017;42:61–6. https://​doi.​org/​10.​1016/​j.​ejim.​2017.​04.​003This study, carried out in Spain, evaluated 2110 consecutive patients who had been discharged after being hospitalized for heart failure. The paper established the percentage of rehospitalizations/month, which was deemed to be 13%. CrossRefPubMed
19.
go back to reference • Sud M, Yu B, Wijeysundera HC, Austin PC, Ko DT, Braga J, et al. Associations between short or long length of stay and 30-day readmission and mortality in hospitalized patients with heart failure. JACC Heart Fail. 2017. https://doi.org/10.1016/j.jchf.2017.03.012This multicenter, cohort study - carried out in Ontario, Canada - evaluated up to 58,230 patients who had heart failure and were > 65 years old. The paper demonstrated that a long hospitalization period was asociated with an increase in all types of hospital readmissions and in mortality. PubMed • Sud M, Yu B, Wijeysundera HC, Austin PC, Ko DT, Braga J, et al. Associations between short or long length of stay and 30-day readmission and mortality in hospitalized patients with heart failure. JACC Heart Fail. 2017. https://​doi.​org/​10.​1016/​j.​jchf.​2017.​03.​012This multicenter, cohort study - carried out in Ontario, Canada - evaluated up to 58,230 patients who had heart failure and were > 65 years old. The paper demonstrated that a long hospitalization period was asociated with an increase in all types of hospital readmissions and in mortality. PubMed
21.
go back to reference Krupickan J, Janota T, Hradec J. Natriuretic peptides in heart failure. Cor et vasa. 2013;55:E370–E6.CrossRef Krupickan J, Janota T, Hradec J. Natriuretic peptides in heart failure. Cor et vasa. 2013;55:E370–E6.CrossRef
27.
go back to reference Zamora E, Lupon J. Heart failure units in Spain: state of the art. Rev Esp Cardiol. 2007;60(8):874–7.CrossRefPubMed Zamora E, Lupon J. Heart failure units in Spain: state of the art. Rev Esp Cardiol. 2007;60(8):874–7.CrossRefPubMed
30.
go back to reference Alvarez-Garcia J, Ferrero-Gregori A, Puig T, Vazquez R, Delgado J, Pascual-Figal D, et al. A simple validated method for predicting the risk of hospitalization for worsening of heart failure in ambulatory patients: the Redin-SCORE. Eur J Heart Fail. 2015;17(8):818–27. https://doi.org/10.1002/ejhf.287.CrossRefPubMed Alvarez-Garcia J, Ferrero-Gregori A, Puig T, Vazquez R, Delgado J, Pascual-Figal D, et al. A simple validated method for predicting the risk of hospitalization for worsening of heart failure in ambulatory patients: the Redin-SCORE. Eur J Heart Fail. 2015;17(8):818–27. https://​doi.​org/​10.​1002/​ejhf.​287.CrossRefPubMed
Metadata
Title
Patient-Associated Predictors of 15- and 30-Day Readmission After Hospitalization for Acute Heart Failure
Authors
Juan F. Delgado
Andreu Ferrero Gregori
Laura Morán Fernández
Ramón Bascompte Claret
Andrés Grau Sepúlveda
Francisco Fernández-Avilés
José R. González-Juanatey
Rafael Vázquez García
Miguel Rivera Otero
Javier Segovia Cubero
Domingo Pascual Figal
Maria G. Crespo-Leiro
Jesús Alvarez-García
Juan Cinca
Fernando Arribas Ynsaurriaga
Publication date
01-12-2019
Publisher
Springer US
Keyword
Heart Failure
Published in
Current Heart Failure Reports / Issue 6/2019
Print ISSN: 1546-9530
Electronic ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-019-00442-1

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