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Published in: Current Pain and Headache Reports 8/2013

01-08-2013 | Secondary Headache (K Henry, Section Editor)

Headache and Epilepsy

Authors: P. R. Bauer, J. A. Carpay, G. M. Terwindt, J. W. Sander, R. J. Thijs, J. Haan, G. H. Visser

Published in: Current Pain and Headache Reports | Issue 8/2013

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Abstract

Headache and epilepsy often co-occur. Epidemiologic studies conducted in the past few years reinforce the notion of a bi-directional association between migraine and epilepsy. Data on an association between headache (in general) and epilepsy, however, are less clear. Peri-ictal headache often presents with migraine-like symptoms and can be severe. A correct diagnosis and management are paramount. It was demonstrated that cortical hyperexcitability may underlie both epilepsy and migraine. A recent study linked spreading depolarisation, the supposed underlying pathophysiological mechanism of migraine with aura, to epilepsy. Although this study was carried out in patients who had suffered a subarachnoid haemorrhage, the finding may shed light on pathophysiological mechanisms common to epilepsy and migraine.
Literature
1.
go back to reference Stovner L, Hagen K, Jensen R, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia. 2007;27(3):193–210.PubMedCrossRef Stovner L, Hagen K, Jensen R, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia. 2007;27(3):193–210.PubMedCrossRef
2.
go back to reference Smitherman TA, Burch R, Sheikh H, Loder E. The prevalence, impact, and treatment of migraine and severe headaches in the United States: a review of statistics from national surveillance studies. Headache. 2013. doi:10.111/head.12074. Smitherman TA, Burch R, Sheikh H, Loder E. The prevalence, impact, and treatment of migraine and severe headaches in the United States: a review of statistics from national surveillance studies. Headache. 2013. doi:10.​111/​head.​12074.
3.
go back to reference MacDonald BK, Cockerell OC, Sander JW, Shorvon SD. The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK. Brain. 2000;123:665–76.PubMedCrossRef MacDonald BK, Cockerell OC, Sander JW, Shorvon SD. The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK. Brain. 2000;123:665–76.PubMedCrossRef
4.
go back to reference Forsgren L, Beghi E, Oun A, Sillanpää M. The epidemiology of epilepsy in Europe - a systematic review. Eur J Neurol. 2005;12(4):245–53.PubMedCrossRef Forsgren L, Beghi E, Oun A, Sillanpää M. The epidemiology of epilepsy in Europe - a systematic review. Eur J Neurol. 2005;12(4):245–53.PubMedCrossRef
6.
go back to reference Kwan P, Man CBL, Leung H, et al. Headache in patients with epilepsy: a prospective incidence study. Epilepsia. 2008;49(6):1099–102.PubMedCrossRef Kwan P, Man CBL, Leung H, et al. Headache in patients with epilepsy: a prospective incidence study. Epilepsia. 2008;49(6):1099–102.PubMedCrossRef
7.
go back to reference Syvertsen M, Helde G, Stovner LJ, Brodtkorb E. Headaches add to the burden of epilepsy. J Headache Pain. 2007;8(4):224–30.PubMedCrossRef Syvertsen M, Helde G, Stovner LJ, Brodtkorb E. Headaches add to the burden of epilepsy. J Headache Pain. 2007;8(4):224–30.PubMedCrossRef
8.
go back to reference Ito M, Adachi N, Nakamura F, et al. Characteristics of postictal headache in patients with partial epilepsy. Cephalalgia. 2004;24(1):23–8.PubMedCrossRef Ito M, Adachi N, Nakamura F, et al. Characteristics of postictal headache in patients with partial epilepsy. Cephalalgia. 2004;24(1):23–8.PubMedCrossRef
9.
go back to reference Nunes JC, Zakon DB, Claudino LS, et al. Headache among mesial temporal lobe epilepsy patients: a case-control study. J Neurol Sci. 2011;306(1-2):20–3.PubMedCrossRef Nunes JC, Zakon DB, Claudino LS, et al. Headache among mesial temporal lobe epilepsy patients: a case-control study. J Neurol Sci. 2011;306(1-2):20–3.PubMedCrossRef
10.
go back to reference Yankovsky AE, Andermann F, Bernasconi A. Characteristics of headache associated with intractable partial epilepsy. Epilepsia. 2005;46(8):1241–5.PubMedCrossRef Yankovsky AE, Andermann F, Bernasconi A. Characteristics of headache associated with intractable partial epilepsy. Epilepsia. 2005;46(8):1241–5.PubMedCrossRef
11.
go back to reference Ottman R, Lipton RB, Ettinger AB, et al. Comorbidities of epilepsy: results from the Epilepsy Comorbidities and Health (EPIC) survey. Epilepsia. 2011;52(2):308–15.PubMed Ottman R, Lipton RB, Ettinger AB, et al. Comorbidities of epilepsy: results from the Epilepsy Comorbidities and Health (EPIC) survey. Epilepsia. 2011;52(2):308–15.PubMed
12.
go back to reference Téllez-Zenteno JF, Matijevic S, Wiebe S. Somatic comorbidity of epilepsy in the general population in Canada. Epilepsia. 2005;46(12):1955–62.PubMedCrossRef Téllez-Zenteno JF, Matijevic S, Wiebe S. Somatic comorbidity of epilepsy in the general population in Canada. Epilepsia. 2005;46(12):1955–62.PubMedCrossRef
13.
go back to reference Le H, Tfelt-Hansen P, Russell MB, et al. Co-morbidity of migraine with somatic disease in a large population-based study. Cephalalgia. 2011;31(1):43–64.PubMedCrossRef Le H, Tfelt-Hansen P, Russell MB, et al. Co-morbidity of migraine with somatic disease in a large population-based study. Cephalalgia. 2011;31(1):43–64.PubMedCrossRef
14.
go back to reference Brodtkorb E, Bakken IJ, Sjaastad O. Comorbidity of migraine and epilepsy in a Norwegian community. Eur J Neurol. 2008;15(12):1421–3.PubMedCrossRef Brodtkorb E, Bakken IJ, Sjaastad O. Comorbidity of migraine and epilepsy in a Norwegian community. Eur J Neurol. 2008;15(12):1421–3.PubMedCrossRef
15.
go back to reference Buse DC, Manack A, Serrano D, Turkel C, Lipton RB. Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. J Neurol Neurosurg Psychiatry. 2010;81(4):428–32.PubMedCrossRef Buse DC, Manack A, Serrano D, Turkel C, Lipton RB. Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. J Neurol Neurosurg Psychiatry. 2010;81(4):428–32.PubMedCrossRef
16.
go back to reference Chen Y-C, Tang C-H, Ng K, Wang S-J. Comorbidity profiles of chronic migraine sufferers in a national database in Taiwan. J Headache Pain. 2012;13(4):311–9.PubMedCrossRef Chen Y-C, Tang C-H, Ng K, Wang S-J. Comorbidity profiles of chronic migraine sufferers in a national database in Taiwan. J Headache Pain. 2012;13(4):311–9.PubMedCrossRef
17.
go back to reference Lateef TM, Cui L, Nelson KB, et al. Physical comorbidity of migraine and other headaches in US adolescents. J Pediatr. 2012;161(2):308–13.PubMedCrossRef Lateef TM, Cui L, Nelson KB, et al. Physical comorbidity of migraine and other headaches in US adolescents. J Pediatr. 2012;161(2):308–13.PubMedCrossRef
18.
go back to reference Olesen J. The international classification of headache disorders. Headache. 2004;24(s1):1–150. Olesen J. The international classification of headache disorders. Headache. 2004;24(s1):1–150.
19.
go back to reference Kelley SA, Hartman AL, Kossoff EH. Comorbidity of migraine in children presenting with epilepsy to a tertiary care center. Neurology. 2012;79(5):468–73.PubMedCrossRef Kelley SA, Hartman AL, Kossoff EH. Comorbidity of migraine in children presenting with epilepsy to a tertiary care center. Neurology. 2012;79(5):468–73.PubMedCrossRef
20.
go back to reference Schankin CJ, Rémi J, Klaus I, et al. Headache in juvenile myoclonic epilepsy. J Headache Pain. 2011;12(2):227–33.PubMedCrossRef Schankin CJ, Rémi J, Klaus I, et al. Headache in juvenile myoclonic epilepsy. J Headache Pain. 2011;12(2):227–33.PubMedCrossRef
21.
go back to reference Baldin E, Ludvigsson P, Mixa O, Hesdorffer DC. Prevalence of recurrent symptoms and their association with epilepsy and febrile seizure in school-aged children: a community-based survey in Iceland. Epilepsy Behav. 2012;23(3):315–9.PubMedCrossRef Baldin E, Ludvigsson P, Mixa O, Hesdorffer DC. Prevalence of recurrent symptoms and their association with epilepsy and febrile seizure in school-aged children: a community-based survey in Iceland. Epilepsy Behav. 2012;23(3):315–9.PubMedCrossRef
22.
go back to reference Duchaczek B, Ghaeni L, Matzen J, Holtkamp M. Interictal and periictal headache in patients with epilepsy. Eur J Neurol. 2012;25:1–7. Duchaczek B, Ghaeni L, Matzen J, Holtkamp M. Interictal and periictal headache in patients with epilepsy. Eur J Neurol. 2012;25:1–7.
23.
go back to reference Tonini MC, Giordano L, Atzeni L, et al. Primary headache and epilepsy: a multicenter cross-sectional study. Epilepsy Behav. 2012;23(3):342–7.PubMedCrossRef Tonini MC, Giordano L, Atzeni L, et al. Primary headache and epilepsy: a multicenter cross-sectional study. Epilepsy Behav. 2012;23(3):342–7.PubMedCrossRef
25.
go back to reference Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676–85.PubMedCrossRef Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676–85.PubMedCrossRef
26.
go back to reference Verrotti A, Striano P, Belcastro V, et al. Migralepsy and related conditions: advances in pathophysiology and classification. Seizure. 2011;20(4):271–5.PubMedCrossRef Verrotti A, Striano P, Belcastro V, et al. Migralepsy and related conditions: advances in pathophysiology and classification. Seizure. 2011;20(4):271–5.PubMedCrossRef
27.
go back to reference Sances G, Guaschino E, Perucca P. Migralepsy: a call for a revision of the definition. Epilepsia. 2009;50(11):2487–96.PubMedCrossRef Sances G, Guaschino E, Perucca P. Migralepsy: a call for a revision of the definition. Epilepsia. 2009;50(11):2487–96.PubMedCrossRef
28.
go back to reference Belcastro V, Striano P, Villa MP, Parisi P. Migralepsy, hemicrania epileptica, post-ictal headache and “ictal epileptic headache”: a proposal for terminology and classification revision. J Headache Pain. 2011;12(3):289–94.PubMedCrossRef Belcastro V, Striano P, Villa MP, Parisi P. Migralepsy, hemicrania epileptica, post-ictal headache and “ictal epileptic headache”: a proposal for terminology and classification revision. J Headache Pain. 2011;12(3):289–94.PubMedCrossRef
29.
go back to reference Parisi P, Striano P, Kasteleijn-Nolst Trenité DGA, et al. “Ictal epileptic headache”: recent concepts for new classifications criteria. Cephalalgia. 2012;32(9):723–4.PubMedCrossRef Parisi P, Striano P, Kasteleijn-Nolst Trenité DGA, et al. “Ictal epileptic headache”: recent concepts for new classifications criteria. Cephalalgia. 2012;32(9):723–4.PubMedCrossRef
30.
go back to reference Dainese F, Mai R, Francione S, et al. Ictal headache: headache as first ictal symptom in focal epilepsy. Epilepsy Behav. 2011;22(4):790–2.PubMedCrossRef Dainese F, Mai R, Francione S, et al. Ictal headache: headache as first ictal symptom in focal epilepsy. Epilepsy Behav. 2011;22(4):790–2.PubMedCrossRef
31.
go back to reference Fanella M, Fattouch J, Casciato S, et al. Ictal epileptic headache as “subtle” symptom in generalized idiopathic epilepsy. Epilepsia. 2012;53(4):e67–70.PubMedCrossRef Fanella M, Fattouch J, Casciato S, et al. Ictal epileptic headache as “subtle” symptom in generalized idiopathic epilepsy. Epilepsia. 2012;53(4):e67–70.PubMedCrossRef
32.
go back to reference • Adcock JE, Panayiotopoulos CP. Occipital lobe seizures and epilepsies. J Clin Neurophysiol. 2012;29(5):397–407. This review gives a very complete overview of occipital lobe seizures.PubMedCrossRef • Adcock JE, Panayiotopoulos CP. Occipital lobe seizures and epilepsies. J Clin Neurophysiol. 2012;29(5):397–407. This review gives a very complete overview of occipital lobe seizures.PubMedCrossRef
33.
go back to reference Haan J, Terwindt GM, Van den Maagdenberg AMJM, et al. A review of the genetic relation between migraine and epilepsy. Cephalalgia. 2008;28(2):105–13.PubMed Haan J, Terwindt GM, Van den Maagdenberg AMJM, et al. A review of the genetic relation between migraine and epilepsy. Cephalalgia. 2008;28(2):105–13.PubMed
34.
go back to reference Anttila V, Stefansson H, Kallela M, et al. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat Genet. 2010;42(10):869–73.PubMedCrossRef Anttila V, Stefansson H, Kallela M, et al. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat Genet. 2010;42(10):869–73.PubMedCrossRef
35.
go back to reference De Vries B, Frants RR, Ferrari MD, Van den Maagdenberg AMJM. Molecular genetics of migraine. Hum Genet. 2009;126(1):115–32.PubMedCrossRef De Vries B, Frants RR, Ferrari MD, Van den Maagdenberg AMJM. Molecular genetics of migraine. Hum Genet. 2009;126(1):115–32.PubMedCrossRef
36.
go back to reference Freilinger T, Anttila V, De Vries B, et al. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat Genet. 2012;44(7):777–82.PubMedCrossRef Freilinger T, Anttila V, De Vries B, et al. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat Genet. 2012;44(7):777–82.PubMedCrossRef
37.
go back to reference Tan NCK, Berkovic SF. The Epilepsy Genetic Association Database (epiGAD): analysis of 165 genetic association studies, 1996-2008. Epilepsia. 2010;51(4):686–9.PubMedCrossRef Tan NCK, Berkovic SF. The Epilepsy Genetic Association Database (epiGAD): analysis of 165 genetic association studies, 1996-2008. Epilepsia. 2010;51(4):686–9.PubMedCrossRef
39.
go back to reference Magis D, Boon E, Coppola G, et al. A novel CACNA1A mutation results in episodic ataxia with migrainous features without headache. Cephalalgia. 2012;32(15):1147–9.PubMedCrossRef Magis D, Boon E, Coppola G, et al. A novel CACNA1A mutation results in episodic ataxia with migrainous features without headache. Cephalalgia. 2012;32(15):1147–9.PubMedCrossRef
40.
go back to reference Marini C, Conti V, Mei D, et al. PRRT2 mutations in familial infantile seizures, paroxysmal dyskinesia, and hemiplegic migraine. Neurology. 2012;79(21):2109–14.PubMedCrossRef Marini C, Conti V, Mei D, et al. PRRT2 mutations in familial infantile seizures, paroxysmal dyskinesia, and hemiplegic migraine. Neurology. 2012;79(21):2109–14.PubMedCrossRef
41.
go back to reference Gardiner AR, Bhatia KP, Stamelou M, et al. PRRT2 gene mutations: from paroxysmal dyskinesia to episodic ataxia and hemiplegic migraine. Neurology. 2012;79(21):2115–21.PubMedCrossRef Gardiner AR, Bhatia KP, Stamelou M, et al. PRRT2 gene mutations: from paroxysmal dyskinesia to episodic ataxia and hemiplegic migraine. Neurology. 2012;79(21):2115–21.PubMedCrossRef
43.
go back to reference Polvi A, Siren A, Kallela M, et al. Shared loci for migraine and epilepsy on chromosomes 14q12-q23 and 12q24.2-q24.3. Neurology. 2012;78(3):202–9.PubMedCrossRef Polvi A, Siren A, Kallela M, et al. Shared loci for migraine and epilepsy on chromosomes 14q12-q23 and 12q24.2-q24.3. Neurology. 2012;78(3):202–9.PubMedCrossRef
44.
go back to reference Somjen GG. Ion regulation in the brain: implications for pathophysiology. Neuroscientist. 2002;8:254–67.PubMed Somjen GG. Ion regulation in the brain: implications for pathophysiology. Neuroscientist. 2002;8:254–67.PubMed
45.
go back to reference Coppola G, Schoenen J. Cortical excitability in chronic migraine. Curr Pain Headache Rep. 2012;16(1):93–100.PubMedCrossRef Coppola G, Schoenen J. Cortical excitability in chronic migraine. Curr Pain Headache Rep. 2012;16(1):93–100.PubMedCrossRef
46.
go back to reference Badawy RAB, Harvey AS, Macdonell RAL. Cortical hyperexcitability and epileptogenesis: understanding the mechanisms of epilepsy - part 1. J Clin Neurosci. 2009;16(3):355–65.PubMedCrossRef Badawy RAB, Harvey AS, Macdonell RAL. Cortical hyperexcitability and epileptogenesis: understanding the mechanisms of epilepsy - part 1. J Clin Neurosci. 2009;16(3):355–65.PubMedCrossRef
47.
go back to reference Garza-López E, Sandoval A, González-Ramírez R, et al. Familial hemiplegic migraine type 1 mutations W1684R and V1696I alter G protein-mediated regulation of Ca(V)2.1 voltage-gated calcium channels. Biochim Biophys Acta. 2012;1822(8):1238–46.PubMedCrossRef Garza-López E, Sandoval A, González-Ramírez R, et al. Familial hemiplegic migraine type 1 mutations W1684R and V1696I alter G protein-mediated regulation of Ca(V)2.1 voltage-gated calcium channels. Biochim Biophys Acta. 2012;1822(8):1238–46.PubMedCrossRef
48.
go back to reference Badawy RAB, Curatolo JM, Newton M, et al. Changes in cortical excitability differentiate generalized and focal epilepsy. Ann Neurol. 2007;61(4):324–31.PubMedCrossRef Badawy RAB, Curatolo JM, Newton M, et al. Changes in cortical excitability differentiate generalized and focal epilepsy. Ann Neurol. 2007;61(4):324–31.PubMedCrossRef
49.
go back to reference Mulleners WM, Chronicle EP, Palmer JE, et al. Visual cortex excitability in migraine with and without aura. Headache. 2001;41(6):565–72.PubMedCrossRef Mulleners WM, Chronicle EP, Palmer JE, et al. Visual cortex excitability in migraine with and without aura. Headache. 2001;41(6):565–72.PubMedCrossRef
50.
go back to reference Van Der Kamp W, Maassenvandenbrink A, Ferrari MD, Van Dijk G. Interictal cortical excitability to magnetic stimulation in familial hemiplegic migraine. Neurology. 1997;1:1996–8. Van Der Kamp W, Maassenvandenbrink A, Ferrari MD, Van Dijk G. Interictal cortical excitability to magnetic stimulation in familial hemiplegic migraine. Neurology. 1997;1:1996–8.
51.
go back to reference •• Badawy RAB, Jackson GD. Cortical excitability in migraine and epilepsy: a common feature? J Clin Neurophysiol. 2012;29(3):244–9. This is, to our knowledge, the first study to directly compare cortical excitability in epilepsy and migraine.PubMedCrossRef •• Badawy RAB, Jackson GD. Cortical excitability in migraine and epilepsy: a common feature? J Clin Neurophysiol. 2012;29(3):244–9. This is, to our knowledge, the first study to directly compare cortical excitability in epilepsy and migraine.PubMedCrossRef
52.
go back to reference Merlo D, Mollinari C, Inaba Y, et al. Reduced GABAB receptor subunit expression and paired-pulse depression in a genetic model of absence seizures. Neurobiol Dis. 2007;25(3):631–41.PubMedCrossRef Merlo D, Mollinari C, Inaba Y, et al. Reduced GABAB receptor subunit expression and paired-pulse depression in a genetic model of absence seizures. Neurobiol Dis. 2007;25(3):631–41.PubMedCrossRef
53.
go back to reference Mathew J, Balakrishnan S, Antony S, et al. Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A. J Biomed Sci. 2012;19(1):25.PubMedCrossRef Mathew J, Balakrishnan S, Antony S, et al. Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A. J Biomed Sci. 2012;19(1):25.PubMedCrossRef
54.
go back to reference Brown JT, Gill CH, Farmer CE, et al. Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices of GABA B1 receptor subunit knockout mice. Epilepsy Res. 2003;57(2–3):121–36.PubMedCrossRef Brown JT, Gill CH, Farmer CE, et al. Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices of GABA B1 receptor subunit knockout mice. Epilepsy Res. 2003;57(2–3):121–36.PubMedCrossRef
55.
go back to reference Holland PR, Akerman S, Goadsby PJ. Cortical spreading depression-associated cerebral blood flow changes induced by mechanical stimulation are modulated by AMPA and GABA receptors. Cephalalgia. 2010;30(5):519–27.PubMed Holland PR, Akerman S, Goadsby PJ. Cortical spreading depression-associated cerebral blood flow changes induced by mechanical stimulation are modulated by AMPA and GABA receptors. Cephalalgia. 2010;30(5):519–27.PubMed
56.
go back to reference Plummer PN, Colson NJ, Lewohl JM, et al. Significant differences in gene expression of GABA receptors in peripheral blood leukocytes of migraineurs. Gene. 2011;490(1–2):32–6.PubMedCrossRef Plummer PN, Colson NJ, Lewohl JM, et al. Significant differences in gene expression of GABA receptors in peripheral blood leukocytes of migraineurs. Gene. 2011;490(1–2):32–6.PubMedCrossRef
57.
go back to reference Russo L, Mariotti P, Sangiorgi E, et al. A new susceptibility locus for migraine with aura in the 15q11-q13 genomic region containing three GABA-A receptor genes. Am J Hum Genet. 2005;76(2):327–33.PubMedCrossRef Russo L, Mariotti P, Sangiorgi E, et al. A new susceptibility locus for migraine with aura in the 15q11-q13 genomic region containing three GABA-A receptor genes. Am J Hum Genet. 2005;76(2):327–33.PubMedCrossRef
58.
go back to reference Oswell G, Kaunisto MA, Kallela M, et al. No association of migraine to the GABA-A receptor complex on chromosome 15. Am J Med Genet. 2008;147B(1):33–6.PubMedCrossRef Oswell G, Kaunisto MA, Kallela M, et al. No association of migraine to the GABA-A receptor complex on chromosome 15. Am J Med Genet. 2008;147B(1):33–6.PubMedCrossRef
59.
go back to reference Netzer C, Freudenberg J, Toliat MR, et al. Genetic association studies of the chromosome 15 GABA-A receptor cluster in migraine with aura. Am J Med Genet. 2008;147B(1):37–41.PubMedCrossRef Netzer C, Freudenberg J, Toliat MR, et al. Genetic association studies of the chromosome 15 GABA-A receptor cluster in migraine with aura. Am J Med Genet. 2008;147B(1):37–41.PubMedCrossRef
60.
go back to reference Fernandez F, Esposito T, Lea RA, et al. Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility. BMC Med Genet. 2008;9:109.PubMedCrossRef Fernandez F, Esposito T, Lea RA, et al. Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility. BMC Med Genet. 2008;9:109.PubMedCrossRef
61.
go back to reference Wallace RH, Marini C, Petrou S, et al. Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. Nat Genet. 2001;28(1):49–52.PubMed Wallace RH, Marini C, Petrou S, et al. Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. Nat Genet. 2001;28(1):49–52.PubMed
62.
go back to reference Baulac S, Huberfeld G, Gourfinkel-An I, et al. First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene. Nat Genet. 2001;28(1):46–8.PubMed Baulac S, Huberfeld G, Gourfinkel-An I, et al. First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene. Nat Genet. 2001;28(1):46–8.PubMed
63.
go back to reference Lachance-Touchette P, Brown P, Meloche C, et al. Novel α1 and γ2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy. Eur J Neurosci. 2011;34(2):237–49.PubMedCrossRef Lachance-Touchette P, Brown P, Meloche C, et al. Novel α1 and γ2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy. Eur J Neurosci. 2011;34(2):237–49.PubMedCrossRef
64.
go back to reference Lauritzen M, Dreier JP, Fabricius M. Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J Cereb Blood Flow Metab. 2011;31(1):17–35.PubMedCrossRef Lauritzen M, Dreier JP, Fabricius M. Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J Cereb Blood Flow Metab. 2011;31(1):17–35.PubMedCrossRef
65.
go back to reference • Dreier JP. The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med. 2011;17(4):439–47. This review addresses the complex issue of spreading depolarization and gives an overview of the current understanding of this phenomenon in relation to neurologic conditions.PubMedCrossRef • Dreier JP. The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med. 2011;17(4):439–47. This review addresses the complex issue of spreading depolarization and gives an overview of the current understanding of this phenomenon in relation to neurologic conditions.PubMedCrossRef
66.
go back to reference Herreras O, Largo C, Ibarz JM, et al. Role of neuronal synchronizing mechanisms in the propagation of spreading depression in the in vivo hippocampus. J Neurosci. 1994;14(11):7087–98.PubMed Herreras O, Largo C, Ibarz JM, et al. Role of neuronal synchronizing mechanisms in the propagation of spreading depression in the in vivo hippocampus. J Neurosci. 1994;14(11):7087–98.PubMed
67.
go back to reference Larrosa B, Pastor J, López-Aguado L, Herreras O. A role for glutamate and glia in the fast network oscillations preceding spreading depression. Neuroscience. 2006;141(2):1057–68.PubMedCrossRef Larrosa B, Pastor J, López-Aguado L, Herreras O. A role for glutamate and glia in the fast network oscillations preceding spreading depression. Neuroscience. 2006;141(2):1057–68.PubMedCrossRef
68.
go back to reference Mayevsky A, Doron A, Manor T, et al. Cortical spreading depression recorded from the human brain using a multiparametric monitoring system. Brain Res. 1996;740(1–2):268–74.PubMedCrossRef Mayevsky A, Doron A, Manor T, et al. Cortical spreading depression recorded from the human brain using a multiparametric monitoring system. Brain Res. 1996;740(1–2):268–74.PubMedCrossRef
69.
go back to reference Strong AJ, Fabricius M, Boutelle MG, et al. Spreading and synchronous depressions of cortical activity in acutely injured human brain. Stroke. 2002;33(12):2738–43.PubMedCrossRef Strong AJ, Fabricius M, Boutelle MG, et al. Spreading and synchronous depressions of cortical activity in acutely injured human brain. Stroke. 2002;33(12):2738–43.PubMedCrossRef
70.
go back to reference Fabricius M, Fuhr S, Bhatia R, et al. Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex. Brain. 2006;129:778–90.PubMedCrossRef Fabricius M, Fuhr S, Bhatia R, et al. Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex. Brain. 2006;129:778–90.PubMedCrossRef
71.
go back to reference •• Dreier JP, Major S, Pannek H-W, et al. Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex. Brain. 2012;135:259–75. This study demonstrates spreading convulsions for the first time in humans, and links cortical spreading depression to later occurrence of epilepsy.PubMedCrossRef •• Dreier JP, Major S, Pannek H-W, et al. Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex. Brain. 2012;135:259–75. This study demonstrates spreading convulsions for the first time in humans, and links cortical spreading depression to later occurrence of epilepsy.PubMedCrossRef
72.
go back to reference Tomkins O, Friedman O, Ivens S, et al. Blood-brain barrier disruption results in delayed functional and structural alterations in the rat neocortex. Neurobiol Dis. 2007;25(2):367–77.PubMedCrossRef Tomkins O, Friedman O, Ivens S, et al. Blood-brain barrier disruption results in delayed functional and structural alterations in the rat neocortex. Neurobiol Dis. 2007;25(2):367–77.PubMedCrossRef
73.
go back to reference Fabricius M, Fuhr S, Willumsen L, et al. Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain. Clin Neurophysiol. 2009;119(9):1973–84.CrossRef Fabricius M, Fuhr S, Willumsen L, et al. Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain. Clin Neurophysiol. 2009;119(9):1973–84.CrossRef
74.
go back to reference Gorji A, Speckmann E. Spreading depression enhances the spontaneous epileptiform activity in human neocortical tissues. Eur J Neurosci. 2004;19:3371–4.PubMedCrossRef Gorji A, Speckmann E. Spreading depression enhances the spontaneous epileptiform activity in human neocortical tissues. Eur J Neurosci. 2004;19:3371–4.PubMedCrossRef
75.
go back to reference Krüger H, Luhmann HJ, Heinemann U. Repetitive spreading depression causes selective suppression of GABAergic function. NeuroReport. 1996;7:2733–6.PubMedCrossRef Krüger H, Luhmann HJ, Heinemann U. Repetitive spreading depression causes selective suppression of GABAergic function. NeuroReport. 1996;7:2733–6.PubMedCrossRef
76.
go back to reference Maslarova A, Alam M, Reiffurth C, et al. Chronically epileptic human and rat neocortex display a similar resistance against spreading depolarization in vitro. Stroke. 2011;42(10):2917–22.PubMedCrossRef Maslarova A, Alam M, Reiffurth C, et al. Chronically epileptic human and rat neocortex display a similar resistance against spreading depolarization in vitro. Stroke. 2011;42(10):2917–22.PubMedCrossRef
77.
go back to reference Van den Maagdenberg AMJM, Pietrobon D, Pizzorusso T, et al. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron. 2004;41(5):701–10.PubMedCrossRef Van den Maagdenberg AMJM, Pietrobon D, Pizzorusso T, et al. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron. 2004;41(5):701–10.PubMedCrossRef
78.
go back to reference •• Van den Maagdenberg AMJM, Pizzorusso T, Kaja S, et al. High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice. Ann Neurol. 2010;67(1):85–98. This study demonstrates that a CACNA1A mutation in mice can lead to a higher susceptibility for cortical spreading depresion.PubMedCrossRef •• Van den Maagdenberg AMJM, Pizzorusso T, Kaja S, et al. High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice. Ann Neurol. 2010;67(1):85–98. This study demonstrates that a CACNA1A mutation in mice can lead to a higher susceptibility for cortical spreading depresion.PubMedCrossRef
79.
go back to reference Dreier JP, Sakowitz OW, Unterberg AW, et al. Migrainous aura starting several minutes after the onset of subarachnoid hemorrhage. Neurology. 2001;57(7):1344–5.PubMedCrossRef Dreier JP, Sakowitz OW, Unterberg AW, et al. Migrainous aura starting several minutes after the onset of subarachnoid hemorrhage. Neurology. 2001;57(7):1344–5.PubMedCrossRef
Metadata
Title
Headache and Epilepsy
Authors
P. R. Bauer
J. A. Carpay
G. M. Terwindt
J. W. Sander
R. J. Thijs
J. Haan
G. H. Visser
Publication date
01-08-2013
Publisher
Springer US
Published in
Current Pain and Headache Reports / Issue 8/2013
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-013-0351-x

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