Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Virology Journal
Published in: Virology Journal 1/2021

Open Access 01-12-2021 | Hantavirus | Research

Cells of the human respiratory tract support the replication of pathogenic Old World orthohantavirus Puumala

Authors: Stefan Hägele, Christian Nusshag, Alexander Müller, Alexandra Baumann, Martin Zeier, Ellen Krautkrämer

Published in: Virology Journal | Issue 1/2021

Login to get access

Abstract

Background

Transmission of all known pathogenic orthohantaviruses (family Hantaviridae) usually occurs via inhalation of aerosols contaminated with viral particles derived from infected rodents and organ manifestation of infections is characterized by lung and kidney involvement. Orthohantaviruses found in Eurasia cause hemorrhagic fever with renal syndrome (HFRS) and New World orthohantaviruses cause hantavirus cardiopulmonary syndrome (HCPS). However, cases of infection with Old World orthohantaviruses with severe pulmonary manifestations have also been observed. Therefore, human airway cells may represent initial targets for orthohantavirus infection and may also play a role in the pathogenesis of infections with Eurasian orthohantaviruses.

Methods

We analyzed the permissiveness of primary endothelial cells of the human pulmonary microvasculature and of primary human epithelial cells derived from bronchi, bronchioles and alveoli for Old World orthohantavirus Puumala virus (PUUV) in vitro. In addition, we examined the expression of orthohantaviral receptors in these cell types. To minimize donor-specific effects, cells from two different donors were tested for each cell type.

Results

Productive infection with PUUV was observed for endothelial cells of the microvasculature and for the three tested epithelial cell types derived from different sites of the respiratory tract. Interestingly, infection and particle release were also detected in bronchial and bronchiolar epithelial cells although expression of the orthohantaviral receptor integrin β3 was not detectable in these cell types. In addition, replication kinetics and viral release demonstrate enormous donor-specific variations.

Conclusions

The human respiratory epithelium is among the first targets of orthohantaviral infection and may contribute to virus replication, dissemination and pathogenesis of HFRS-causing orthohantaviruses. Differences in initial pulmonary infection due to donor-specific factors may play a role in the observed broad variance of severity and symptoms of orthohantavirus disease in patients. The absence of detectable levels of integrin αVβ3 surface expression on bronchial and small airway epithelial cells indicates an alternate mode of orthohantaviral entry in these cells that is independent from integrin β3.
Literature
1.
Vaheri A, Strandin T, Hepojoki J, Sironen T, Henttonen H, Makela S, Mustonen J. Uncovering the mysteries of hantavirus infections. Nat Rev Microbiol. 2013;11:539–50.PubMedCrossRef
2.
3.
Manigold T, Vial P. Human hantavirus infections: epidemiology, clinical features, pathogenesis and immunology. Swiss Med Wkly. 2014;144:w13937.PubMed
4.
Krautkrämer E, Krüger DH, Zeier M. Recent outbreaks of hantavirus disease in Germany and in the United States. Kidney Int. 2012;82:1243–5.PubMedCrossRef
5.
Zaki SR, Greer PW, Coffield LM, Goldsmith CS, Nolte KB, Foucar K, Feddersen RM, Zumwalt RE, Miller GL, Khan AS, et al. Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease. Am J Pathol. 1995;146:552–79.PubMedPubMedCentral
6.
Kim S, Kang ET, Kim YG, Han JS, Lee JS, Kim YI, Hall WC, Dalrymple JM, Peters CJ. Localization of Hantaan viral envelope glycoproteins by monoclonal antibodies in renal tissues from patients with Korean hemorrhagic fever H. Am J Clin Pathol. 1993;100:398–403.PubMedCrossRef
7.
Krautkrämer E, Grouls S, Stein N, Reiser J, Zeier M. Pathogenic old world hantaviruses infect renal glomerular and tubular cells and induce disassembling of cell-to-cell contacts. J Virol. 2011;85:9811–23.PubMedPubMedCentralCrossRef
8.
Latus J, Tenner-Racz K, Racz P, Kitterer D, Cadar D, Ott G, Alscher MD, Schmidt-Chanasit J, Braun N. Detection of Puumala hantavirus antigen in human intestine during acute hantavirus infection. PLoS ONE. 2014;9:e98397.PubMedPubMedCentralCrossRef
9.
Gizzi M, Delaere B, Weynand B, Clement J, Maes P, Vergote V, Laenen L, Hjelle B, Verroken A, Dive A, et al. Another case of “European hantavirus pulmonary syndrome” with severe lung, prior to kidney, involvement, and diagnosed by viral inclusions in lung macrophages. Eur J Clin Microbiol Infect Dis. 2013;32:1341–5.PubMedPubMedCentralCrossRef
10.
Pettersson L, Rasmuson J, Andersson C, Ahlm C, Evander M. Hantavirus-specific IgA in saliva and viral antigen in the parotid gland in patients with hemorrhagic fever with renal syndrome. J Med Virol. 2011;83:864–70.PubMedCrossRef
11.
Pettersson L, Klingstrom J, Hardestam J, Lundkvist A, Ahlm C, Evander M. Hantavirus RNA in saliva from patients with hemorrhagic fever with renal syndrome. Emerg Infect Dis. 2008;14:406–11.PubMedPubMedCentralCrossRef
12.
Rasmuson J, Andersson C, Norrman E, Haney M, Evander M, Ahlm C. Time to revise the paradigm of hantavirus syndromes? Hantavirus pulmonary syndrome caused by European hantavirus. Eur J Clin Microbiol Infect Dis. 2011;30:685–90.PubMedPubMedCentralCrossRef
13.
Gavrilovskaya IN, Shepley M, Shaw R, Ginsberg MH, Mackow ER. beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc Natl Acad Sci USA. 1998;95:7074–9.PubMedPubMedCentralCrossRef
14.
Gavrilovskaya IN, Brown EJ, Ginsberg MH, Mackow ER. Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. J Virol. 1999;73:3951–9.PubMedPubMedCentralCrossRef
15.
Krautkrämer E, Zeier M. Hantavirus causing hemorrhagic fever with renal syndrome enters from the apical surface and requires decay-accelerating factor (DAF/CD55). J Virol. 2008;82:4257–64.PubMedPubMedCentralCrossRef
16.
Popugaeva E, Witkowski PT, Schlegel M, Ulrich RG, Auste B, Rang A, Krüger DH, Klempa B. Dobrava-Belgrade hantavirus from Germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans. PLoS ONE. 2012;7:e35587.PubMedPubMedCentralCrossRef
17.
Klempa B, Witkowski PT, Popugaeva E, Auste B, Koivogui L, Fichet-Calvet E, Strecker T, Ter Meulen J, Krüger DH. Sangassou virus, the first hantavirus isolate from Africa, displays distinct genetic and functional properties in the group of Murinae-associated hantaviruses. J Virol. 2012;86:3819–27.PubMedPubMedCentralCrossRef
18.
Du H, Li J, Jiang W, Yu H, Zhang Y, Wang J, Wang P, Bai X. Clinical study of critical patients with hemorrhagic fever with renal syndrome complicated by acute respiratory distress syndrome. PLoS ONE. 2014;9:e89740.PubMedPubMedCentralCrossRef
19.
Linderholm M, Sandstrom T, Rinnstrom O, Groth S, Blomberg A, Tarnvik A. Impaired pulmonary function in patients with hemorrhagic fever with renal syndrome. Clin Infect Dis. 1997;25:1084–9.PubMedCrossRef
20.
Rasmuson J, Pourazar J, Linderholm M, Sandström T, Blomberg A, Ahlm C. Presence of activated airway T lymphocytes in human puumala hantavirus disease. Chest. 2011;140:715–22.PubMedCrossRef
21.
Vollmar P, Lubnow M, Simon M, Muller T, Bergler T, Alois P, Thoma BR, Essbauer S. Hantavirus cardiopulmonary syndrome due to Puumala virus in Germany. J Clin Virol. 2016;84:42–7.PubMedCrossRef
22.
Sironen T, Sane J, Lokki ML, Meri S, Andersson LC, Hautala T, Kauma H, Vuorinen S, Rasmuson J, Evander M, et al. Fatal Puumala Hantavirus disease: involvement of complement activation and vascular leakage in the pathobiology. Open Forum Infect Dis. 2017;4:ofx229.PubMedPubMedCentralCrossRef
23.
Borges AA, Campos GM, Moreli ML, Souza RL, Aquino VH, Saggioro FP, Figueiredo LT. Hantavirus cardiopulmonary syndrome: immune response and pathogenesis. Microbes Infect. 2006;8:2324–30.PubMedCrossRef
24.
Terajima M, Hayasaka D, Maeda K, Ennis FA. Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers? Immunol Lett. 2007;113:117–20.PubMedPubMedCentralCrossRef
25.
Rasmuson J, Pourazar J, Mohamed N, Lejon K, Evander M, Blomberg A, Ahlm C. Cytotoxic immune responses in the lungs correlate to disease severity in patients with hantavirus infection. Eur J Clin Microbiol Infect Dis. 2016;35:713–21.PubMedPubMedCentralCrossRef
26.
Scholz S, Baharom F, Rankin G, Maleki KT, Gupta S, Vangeti S, Pourazar J, Discacciati A, Hoijer J, Bottai M, et al. Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways. PLoS Pathog. 2017;13:e1006462.PubMedPubMedCentralCrossRef
27.
Ler Z, Obradović M, Gligić A. Hemorrhagic fever with renal syndrome–etiology. Med Arh. 1991;45:55–8.PubMed
28.
Reip A, Haring B, Sibold C, Stohwasser R, Bautz EK, Darai G, Meisel H, Krüger DH. Coding strategy of the S and M genomic segments of a hantavirus representing a new subtype of the Puumala serotype. Arch Virol. 1995;140:2011–26.PubMedCrossRef
29.
Heino J, Ignotz RA, Hemler ME, Crouse C, Massagué J. Regulation of cell adhesion receptors by transforming growth factor-beta. Concomitant regulation of integrins that share a common beta 1 subunit. J Biol Chem. 1989;264:380–8.PubMedCrossRef
30.
Handke W, Krüger DH, Rang A. Defective particles can lead to underestimated antibody titers in virus neutralization tests. Intervirology. 2009;52:335–9.PubMedCrossRef
31.
Chan MC, Chan RW, Yu WC, Ho CC, Yuen KM, Fong JH, Tang LL, Lai WW, Lo AC, Chui WH, et al. Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract. Am J Pathol. 2010;176:1828–40.PubMedPubMedCentralCrossRef
32.
Sungnak W, Huang N, Becavin C, Berg M, Queen R, Litvinukova M, Talavera-Lopez C, Maatz H, Reichart D, Sampaziotis F, et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020;26:681–7.PubMedPubMedCentralCrossRef
33.
Korva M, Duh D, Saksida A, Trilar T, Avsic-Zupanc T. The hantaviral load in tissues of naturally infected rodents. Microbes Infect. 2009;11:344–51.PubMedCrossRef
34.
Garanina E, Martynova E, Davidyuk Y, Kabwe E, Ivanov K, Titova A, Markelova M, Zhuravleva M, Cherepnev G, Shakirova VG, et al. Cytokine storm combined with humoral immune response defect in fatal hemorrhagic fever with renal syndrome case, Tatarstan, Russia. Viruses. 2019;11:601.PubMedCentralCrossRef
35.
Rankin GD, Rasmuson J, Pourazar J, Blomberg A, Ahlm C. Immunolocalization of Puumala hantavirus in human endobronchial biopsies. In: Am J Respir Crit Care Med Conference, vol. 191. Denver, Colorado: Am J Respir Crit Care Med; 2015.
36.
Pizarro E, Navarrete M, Mendez C, Zaror L, Mansilla C, Tapia M, Carrasco C, Salazar P, Murua R, Padula P, et al. Immunocytochemical and ultrastructural evidence supporting that Andes Hantavirus (ANDV) is transmitted person-to-person through the respiratory and/or salivary pathways. Front Microbiol. 2019;10:2992.PubMedCrossRef
37.
Sundstrom KB, Nguyen Hoang AT, Gupta S, Ahlm C, Svensson M, Klingstrom J. Andes Hantavirus-Infection of a 3D Human Lung Tissue Model Reveals a Late Peak in Progeny Virus Production Followed by Increased Levels of Proinflammatory Cytokines and VEGF-A. PLoS ONE. 2016;11:e0149354.PubMedPubMedCentralCrossRef
38.
Rowe RK, Pekosz A. Bidirectional virus secretion and nonciliated cell tropism following Andes virus infection of primary airway epithelial cell cultures. J Virol. 2006;80:1087–97.PubMedPubMedCentralCrossRef
39.
Witkowski PT, Bourquain D, Bankov K, Auste B, Dabrowski PW, Nitsche A, Krüger DH, Schaade L. Infection of human airway epithelial cells by different subtypes of Dobrava-Belgrade virus reveals gene expression patterns corresponding to their virulence potential. Virology. 2016;493:189–201.PubMedCrossRef
40.
Stoltz M, Klingstrom J. Alpha/beta interferon (IFN-alpha/beta)-independent induction of IFN-lambda1 (interleukin-29) in response to Hantaan virus infection. J Virol. 2010;84:9140–8.PubMedPubMedCentralCrossRef
41.
Lee MH, Lalwani P, Raftery MJ, Matthaei M, Lutteke N, Kirsanovs S, Binder M, Ulrich RG, Giese T, Wolff T, et al. RNA helicase retinoic acid-inducible gene I as a sensor of Hantaan virus replication. J Gen Virol. 2011;92:2191–200.PubMedCrossRef
42.
Shim SH, Park MS, Moon S, Park KS, Song JW, Song KJ, Baek LJ. Comparison of innate immune responses to pathogenic and putative non-pathogenic hantaviruses in vitro. Virus Res. 2011;160:367–73.PubMedCrossRef
43.
Hägele S, Müller A, Nusshag C, Reiser J, Zeier M, Krautkrämer E. Virus- and cell type-specific effects in orthohantavirus infection. Virus Res. 2019;260:102–13.PubMedCrossRef
44.
Golden JW, Hammerbeck CD, Mucker EM, Brocato RL. Animal models for the study of Rodent-Borne hemorrhagic fever viruses: arenaviruses and hantaviruses. Biomed Res Int. 2015;2015:793257.PubMedPubMedCentral
45.
Bourquain D, Bodenstein C, Schurer S, Schaade L. Puumala and Tula Virus differ in replication kinetics and innate immune stimulation in human endothelial cells and macrophages. Viruses. 2019;11:855.PubMedCentralCrossRef
46.
Temonen M, Vapalahti O, Holthofer H, Brummer-Korvenkontio M, Vaheri A, Lankinen H. Susceptibility of human cells to Puumala virus infection. J Gen Virol. 1993;74(Pt 3):515–8.PubMedCrossRef
47.
Damjanovich L, Albelda SM, Mette SA, Buck CA. Distribution of integrin cell adhesion receptors in normal and malignant lung tissue. Am J Respir Cell Mol Biol. 1992;6:197–206.PubMedCrossRef
48.
Mette SA, Pilewski J, Buck CA, Albelda SM. Distribution of integrin cell adhesion receptors on normal bronchial epithelial cells and lung cancer cells in vitro and in vivo. Am J Respir Cell Mol Biol. 1993;8:562–72.PubMedCrossRef
49.
Singh B, Janardhan KS, Kanthan R. Expression of angiostatin, integrin alphavbeta3, and vitronectin in human lungs in sepsis. Exp Lung Res. 2005;31:771–82.PubMedCrossRef
50.
Buranda T, Wu Y, Perez D, Jett SD, BonduHawkins V, Ye C, Edwards B, Hall P, Larson RS, Lopez GP, et al. Recognition of decay accelerating factor and alpha(v)beta(3) by inactivated hantaviruses: toward the development of high-throughput screening flow cytometry assays. Anal Biochem. 2010;402:151–60.PubMedPubMedCentralCrossRef
51.
Choi Y, Kwon YC, Kim SI, Park JM, Lee KH, Ahn BY. A hantavirus causing hemorrhagic fever with renal syndrome requires gC1qR/p32 for efficient cell binding and infection. Virology. 2008;381:178–83.PubMedCrossRef
52.
Jangra RK, Herbert AS, Li R, Jae LT, Kleinfelter LM, Slough MM, Barker SL, Guardado-Calvo P, Roman-Sosa G, Dieterle ME, et al. Protocadherin-1 is essential for cell entry by New World hantaviruses. Nature. 2018;563:559–63.PubMedPubMedCentralCrossRef
53.
Mayor J, Torriani G, Rothenberger S, Engler O. T-cell immunoglobulin and mucin (TIM) contributes to the infection of human airway epithelial cells by pseudotype viruses containing Hantaan virus glycoproteins. Virology. 2020;543:54–62.PubMedCrossRef
54.
Higa MM, Petersen J, Hooper J, Doms RW. Efficient production of Hantaan and Puumala pseudovirions for viral tropism and neutralization studies. Virology. 2012;423:134–42.PubMedCrossRef
55.
Raftery MJ, Lalwani P, Krautkrämer E, Peters T, Scharffetter-Kochanek K, Krüger R, Hofmann J, Seeger K, Krüger DH, Schonrich G. beta2 integrin mediates hantavirus-induced release of neutrophil extracellular traps. J Exp Med. 2014;211:1485–97.PubMedPubMedCentralCrossRef
56.
Müller A, Baumann A, Essbauer S, Radosa L, Krüger DH, Witkowski PT, Zeier M, Krautkrämer E. Analysis of the integrin beta3 receptor for pathogenic orthohantaviruses in rodent host species. Virus Res. 2019;267:36–40.PubMedCrossRef
57.
Torriani G, Mayor J, Zimmer G, Kunz S, Rothenberger S, Engler O. Macropinocytosis contributes to hantavirus entry into human airway epithelial cells. Virology. 2019;531:57–68.PubMedCrossRef
58.
Travanty E, Zhou B, Zhang H, Di YP, Alcorn JF, Wentworth DE, Mason R, Wang J. Differential susceptibilities of human lung primary cells to H1N1 influenza viruses. J Virol. 2015;89:11935–44.PubMedPubMedCentralCrossRef
59.
Sauerhering L, Zickler M, Elvert M, Behner L, Matrosovich T, Erbar S, Matrosovich M, Maisner A. Species-specific and individual differences in Nipah virus replication in porcine and human airway epithelial cells. J Gen Virol. 2016;97:1511–9.PubMedCrossRef
60.
Baigildina AA, Khaiboullina SF, Martynova EV, Anokhin VA, Lombardi VC, Rizvanov AA. Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica. Biomark Med. 2015;9:99–107.PubMedCrossRef
61.
Martynova E, Davidyuk Y, Kabwe E, Garanina EE, Shakirova V, Pavelkina V, Uskova Y, Stott RJ, Foster TL, Markelova M, et al. Cytokine, chemokine, and metalloprotease activation in the serum of patients with nephropathia epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia. Pathogens. 2021;10:527.PubMedPubMedCentralCrossRef
62.
Mustonen J, Outinen T, Laine O, Pörsti I, Vaheri A, Mäkelä S. Kidney disease in Puumala hantavirus infection. Infect Dis (Lond). 2017;49:321–32.CrossRef
63.
Kitterer D, Segerer S, Dippon J, Alscher MD, Braun N, Latus J. Smoking is a risk factor for severe acute kidney injury in hantavirus-induced nephropathia epidemica. Nephron. 2016;134:89–94.PubMedCrossRef
64.
Charbonnel N, Pages M, Sironen T, Henttonen H, Vapalahti O, Mustonen J, Vaheri A. Immunogenetic factors affecting susceptibility of humans and rodents to hantaviruses and the clinical course of hantaviral disease in humans. Viruses. 2014;6:2214–41.PubMedPubMedCentralCrossRef
65.
Maes P, Clement J, Groeneveld PH, Colson P, Huizinga TW, Van Ranst M. Tumor necrosis factor-alpha genetic predisposing factors can influence clinical severity in nephropathia epidemica. Viral Immunol. 2006;19:558–64.PubMedCrossRef
66.
Kanerva M, Vaheri A, Mustonen J, Partanen J. High-producer allele of tumour necrosis factor-alpha is part of the susceptibility MHC haplotype in severe puumala virus-induced nephropathia epidemica. Scand J Infect Dis. 1998;30:532–4.PubMedCrossRef
67.
Mäkelä S, Hurme M, Ala-Houhala I, Mustonen J, Koivisto AM, Partanen J, Vapalahti O, Vaheri A, Pasternack A. Polymorphism of the cytokine genes in hospitalized patients with Puumala hantavirus infection. Nephrol Dial Transplant. 2001;16:1368–73.PubMedCrossRef
68.
Figueiredo LT, Souza WM, Ferrés M, Enria DA. Hantaviruses and cardiopulmonary syndrome in South America. Virus Res. 2014;187:43–54.PubMedCrossRef
69.
Martinez VP, Bellomo C, San Juan J, Pinna D, Forlenza R, Elder M, Padula PJ. Person-to-person transmission of Andes virus. Emerg Infect Dis. 2005;11:1848–53.PubMedPubMedCentralCrossRef
70.
Martinez VP, Di Paola N, Alonso DO, Perez-Sautu U, Bellomo CM, Iglesias AA, Coelho RM, Lopez B, Periolo N, Larson PA, et al. “Super-Spreaders” and person-to-person transmission of Andes Virus in Argentina. N Engl J Med. 2020;383:2230–41.PubMedCrossRef
Metadata
Title
Cells of the human respiratory tract support the replication of pathogenic Old World orthohantavirus Puumala
Authors
Stefan Hägele
Christian Nusshag
Alexander Müller
Alexandra Baumann
Martin Zeier
Ellen Krautkrämer
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2021
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-021-01636-7

Other articles of this Issue 1/2021

Virology Journal 1/2021 Go to the issue

Review

Precision therapeutic targets for COVID-19

Review

Packaging signal of influenza A virus

Research

Construction of an infectious clone of Zika virus stably expressing an EGFP marker in a eukaryotic expression system

Research

Immunostimulatory siRNA with a uridine bulge leads to potent inhibition of HBV and activation of innate immunity

Research

Comparison of 11 respiratory pathogens among hospitalized children before and during the COVID-19 epidemic in Shenzhen, China

Short report

Optimal preparation of SARS-CoV-2 viral transport medium for culture
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits