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Clinical Oral Investigations

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01-01-2024 | Halitosis | Research

The assessment of halitosis with a new screening tool in medication-related osteonecrosis of the jaw

Authors: Yiseul Choi, Jaeyeon Kim, Yumie Rhee, Jin Hoo Park, Woong Nam, Wonse Park

Published in: Clinical Oral Investigations | Issue 1/2024

Abstract

Objectives

This study aimed to identify the levels of halitosis in patients with Medication-related osteonecrosis of the jaw (MRONJ) and osteoporosis and to suggest a new MRONJ screening method using halitosis measurement.

Materials and Methods

From October 2019 to April 2023, participants aged 19 years or older without periodontal disease were selected. Seventy-five participants, 25 in each group, were divided into an MRONJ group, an osteoporosis group without MRONJ, and a control group without osteoporosis and not taking osteoporosis drugs or antibiotics. Each participant underwent halitosis assessment twice using an exhaled breath analyzer to measure halitosis twice by blowing a straw for 1 min. Measured concentrations of hydrogen, hydrogen sulfide, and methyl mercaptan were compared between groups.

Results

Data from 22 patients in the MRONJ group, 25 in the osteoporosis group, and 25 in the control group were analyzed. The concentrations of hydrogen sulfide and methyl mercaptan were significantly higher in the MRONJ group than in the other groups, but the concentrations of hydrogen did not differ between the groups. When comparing the concentrations of hydrogen sulfide and methyl mercaptan in osteoporosis patients and solid cancer patients in the MRONJ group, there was a significant difference in hydrogen sulfide concentration, but there was no significant difference in methyl mercaptan.

Conclusions

Quantifying the level of halitosis can be used to screen for MRONJ in patients taking bisphosphonates, such as patients with osteoporosis, prostate cancer, and breast cancer.

Clinical Relevance

MRONJ is accompanied by bad breath, and the concentrations of hydrogen sulfide and methyl mercaptan are associated with MRONJ.

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Title: The assessment of halitosis with a new screening tool in medication-related osteonecrosis of the jaw
Authors: Yiseul Choi
Jaeyeon Kim
Yumie Rhee
Jin Hoo Park
Woong Nam
Wonse Park
Publication date: 01-01-2024
Publisher: Springer Berlin Heidelberg
Keywords: Halitosis
Halitosis
Osteoporosis
Osteoporosis
Osteonecrosis
Gingival Diseases
Bisphosphonate
Published in: Clinical Oral Investigations / Issue 1/2024
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-024-05506-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The assessment of halitosis with a new screening tool in medication-related osteonecrosis of the jaw

Abstract

Objectives

Materials and Methods

Results

Conclusions

Clinical Relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and Methods

Results

Conclusions

Clinical Relevance

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