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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 5/2019

01-05-2019 | Guillain-Barré Syndrome | Scientific Letter

Do All Children with Guillain Barré Syndrome Need Immunotherapy?

Authors: Mahesh Kamate, Mayank Detroja, Anuraag Nalla Reddy

Published in: Indian Journal of Pediatrics | Issue 5/2019

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Excerpt

To the Editor: According to the published guidelines, patients with Guillain-Barré syndrome (GBS) who have Hughes disability score of 3 (inability to walk >5 m unaided) or more in first 2-wk of illness need immunotherapy [Intra-venous immunoglobulin (IVIG) or plasma exchange (PE)] [1‐3]. Immunotherapy is both expensive and invasive; not widely available also. There is paucity of good quality data on treatment of GBS in children. The adult guidelines may not hold good for children, as many even with higher disability score do improve without immunotherapy [4]. …
Literature
1.
Hughes RA, Swan AV, Raphaël JC, Annane D, van Koningsveld R, van Doorn PA. Immunotherapy for Guillain-Barre syndrome: a systematic review. Brain. 2007;130:2245–57.CrossRefPubMed
2.
van Doorn PA, Ruts L, Jacobs BC. Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome. Lancet Neurol. 2008;7:939–50.CrossRefPubMed
3.
van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA. Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol. 2014;10:469–82.CrossRefPubMed
4.
Gurses N, Uysal S, Cetinkaya F, Islek I, Kalaysi AG. Intravenous immunoglobulin treatment in children with guillain-Barre syndrome. Scand J Infect Dis. 1995;27:241–3.CrossRefPubMed
Metadata
Title
Do All Children with Guillain Barré Syndrome Need Immunotherapy?
Authors
Mahesh Kamate
Mayank Detroja
Anuraag Nalla Reddy
Publication date
01-05-2019
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 5/2019
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-019-02864-0

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