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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2023

Open Access 01-12-2023 | Gout | Research

Effect of nanoparticles on gouty arthritis: a systematic review and meta-analysis

Authors: Ruiting Zhu, Yirou Niu, Wei Zhou, Saikun Wang, Jing Mao, Yingze Guo, Yangyang Lei, Xuance Xiong, Yingzhi Li, Lirong Guo

Published in: BMC Musculoskeletal Disorders | Issue 1/2023

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Abstract

Objective

The purpose of this study was to explore the effects of nanoparticles on gouty arthritis, and to provide evidence for the preclinical application of nanoparticles in gouty arthritis and ideas for nanomedicine improvement for nanoparticle researchers.

Methods

Five databases including the Cochrane Library, PubMed, Scopus, Web of Science, and Embase were searched for eligible studies until April 2022. The quality of the selected studies was assessed by SYRCLE’s risk of bias (RoB) tool, and the random-effects model was used to calculate the overall effect sizes of weighted mean differences (WMD).

Results

Ten studies met the inclusion criteria. Results showed that nanoparticles were effective in reducing uric acid levels (WMD: -4.91; 95% confidence interval (CI): − 5.41 to − 4.41; p < 0.001), but were not better than allopurinol (WMD: -0.20; 95% CI: − 0.42 to 0.02; p = 0.099). It was worth noting that the nanoparticles were safer than allopurinol. Subgroup analyses indicated that nanoparticle encapsulated substance, animal species, nanoparticle dosage, animal quantity, and animal gender were all sources of heterogeneity.

Conclusion

The nanoparticles are safe medications for gouty arthritis which can effectively reduce uric acid levels in rodents. Although the results are still uncertain, it is expected to have certain clinical application value. The nanoparticles may be the preclinical medications for gouty arthritis in the future.
Appendix
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Metadata
Title
Effect of nanoparticles on gouty arthritis: a systematic review and meta-analysis
Authors
Ruiting Zhu
Yirou Niu
Wei Zhou
Saikun Wang
Jing Mao
Yingze Guo
Yangyang Lei
Xuance Xiong
Yingzhi Li
Lirong Guo
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2023
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-023-06186-3

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