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Trials
Published in: Trials 1/2013

Open Access 01-12-2013 | Study protocol

Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)

Authors: Linda Clare, Antony Bayer, Alistair Burns, Anne Corbett, Roy Jones, Martin Knapp, Michael Kopelman, Aleksandra Kudlicka, Iracema Leroi, Jan Oyebode, Jackie Pool, Bob Woods, Rhiannon Whitaker

Published in: Trials | Issue 1/2013

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Abstract

Background

Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer’s disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers.

Methods/design

In this multi-centre, single-blind randomised controlled trial, 480 people with early-stage dementia, each with a carer, will be randomised to receive either treatment as usual or cognitive rehabilitation (10 therapy sessions over 3 months, followed by 4 maintenance sessions over 6 months). We will compare the effectiveness of cognitive rehabilitation with that of treatment as usual with regard to improving self-reported and carer-rated goal performance in areas identified as causing concern by people with early-stage dementia; improving quality of life, self-efficacy, mood and cognition of people with early-stage dementia; and reducing stress levels and ameliorating quality of life for carers of participants with early-stage dementia. The incremental cost-effectiveness of goal-oriented cognitive rehabilitation compared to treatment as usual will also be examined.

Discussion

If the study confirms the benefits and cost-effectiveness of cognitive rehabilitation, it will be important to examine how the goal-oriented cognitive rehabilitation approach can most effectively be integrated into routine health-care provision. Our aim is to provide training and develop materials to support the implementation of this approach following trial completion.

Trial registration

Current Controlled Trials ISRCTN21027481
Appendix
Available only for authorised users
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Metadata
Title
Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)
Authors
Linda Clare
Antony Bayer
Alistair Burns
Anne Corbett
Roy Jones
Martin Knapp
Michael Kopelman
Aleksandra Kudlicka
Iracema Leroi
Jan Oyebode
Jackie Pool
Bob Woods
Rhiannon Whitaker
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Trials / Issue 1/2013
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-14-152

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