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Virology Journal
Published in: Virology Journal 1/2023

Open Access 01-12-2023 | Research

Glycyrrhiza polysaccharides inhibits PRRSV replication

Authors: Youbing Yang, Yongjian Liu, Ran Lou, Ying Lei, Gan Li, Zhiqian Xu, Xiangbin You

Published in: Virology Journal | Issue 1/2023

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Abstract

Glycyrrhiza polysaccharide (GCP) is a natural plant active polysaccharide extracted from traditional Chinese medicine licorice. In this research, we studied the antiviral activity of glycyrrhiza polysaccharide against porcine reproductive and respiratory syndrome virus (PRRSV), a virus of the Arteriviridae family, with a high rate of variation and has caused huge economic losses to the pig industry in various countries since its discovery. Our results show that GCP can inhibit PRRSV replication in a dose-dependent manner. Furthermore, GCP could inhibit the mRNA expression of receptor genes CD163 and NF-κB p65 and promote the mRNA expression of the SLA-7 gene. Because of these results, GCP can be used as a candidate drug to prevent and treat PRRS.
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Metadata
Title
Glycyrrhiza polysaccharides inhibits PRRSV replication
Authors
Youbing Yang
Yongjian Liu
Ran Lou
Ying Lei
Gan Li
Zhiqian Xu
Xiangbin You
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2023
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-023-02052-9

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