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BMC Public Health
Published in: BMC Public Health 1/2024

Open Access 01-12-2024 | Research

Global trends and partial forecast of adverse effects of medical treatment from 1990 to 2019: an epidemiological analysis based on the global burden of disease study 2019

Authors: Xin Kong, Xufeng Tao, Lu Li, Xinya Zhao, Jiaqi Ren, Shilei Yang, Xuyang Chen, Hong Xiang, Guoyu Wu, Yunming Li, Deshi Dong

Published in: BMC Public Health | Issue 1/2024

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Abstract

Background

The possibility of adverse effects of medical treatment (AEMT) is increasing worldwide, but little is known about AEMT in China. This study analyzed the health burden of AEMT in China in recent years through the Global Burden of Disease Study (GBD) 2019 and compared it with the worldwide average level and those in different sociodemographic index (SDI) regions.

Methods

We calculated the age-standardized rate (ASR) of deaths, disability-adjusted life years (DALYs), years of life lost (YLLs), years lived with disability (YLDs), incidence and prevalence attributed to AEMT in China, worldwide and countries with different sociodemographic indices during 1990–2019 using the latest data and methods from the GBD 2019.

Results

From 1990 to 2019, the global age-standardized death rate (ASDR), DALYs, and YLLs for AEMT showed a significant downward trend and were negatively associated with the SDI. By 2040, the ASDR is expected to reach approximately 1.58 (95% UI: 1.33–1.80). From 1990 to 2019, there was no significant change in the global incidence of AEMT. The occurrence of AEMT was related to sex, and the incidence of AEMT was greater among females. In addition, the incidence of AEMT-related injuries and burdens, such as ASR of DALYs, ASR of YLLs and ASR of YLDs, was greater among women than among men. Very old and very young people were more likely to be exposed to AEMT.

Conclusions

From 1990 to 2019, progress was made worldwide in reducing the harm caused by AEMT. However, the incidence and prevalence of AEMT did not change significantly overall during this period. Therefore, the health sector should pay more attention to AEMT and take effective measures to reduce AEMT.
Literature
1.
Brennan TA, Leape LL, Laird NM, Hebert L, Localio AR, Lawthers AG, Newhouse JP, Weiler PC, Hiatt HH. Incidence of adverse events and negligence in hospitalized patients. Results of the Harvard Medical Practice Study I. N Engl J Med. 1991;324(6):370–6.CrossRefPubMed
2.
de Vries EN, Ramrattan MA, Smorenburg SM, Gouma DJ, Boermeester MA. The incidence and nature of in-hospital adverse events: a systematic review. Qual Saf Health Care. 2008;17(3):216–23.CrossRefPubMed
3.
Makary MA, Daniel M. Medical error-the third leading cause of death in the US. BMJ. 2016;353:i2139.CrossRefPubMed
4.
MA Xudong. The classification of adverse events on Medical Quality and Safety in China. Chin Health Qual Manage 2021, 28(06).
5.
Lunevicius R, Haagsma JA. Incidence and mortality from adverse effects of medical treatment in the UK, 1990–2013: levels, trends, patterns and comparisons. Int J Qual Health Care. 2018;30(7):558–64.CrossRefPubMedPubMedCentral
6.
Wilson RM, Michel P, Olsen S, Gibberd RW, Vincent C, El-Assady R, Rasslan O, Qsous S, Macharia WM, Sahel A, et al. Patient safety in developing countries: retrospective estimation of scale and nature of harm to patients in hospital. BMJ. 2012;344:e832.CrossRefPubMed
7.
Donaldson LJ, Kelley ET, Dhingra-Kumar N, Kieny MP, Sheikh A. Medication without harm: WHO’s Third Global Patient Safety Challenge. Lancet. 2017;389(10080):1680–1.CrossRefPubMed
8.
Xue Y, Yang J, Zhang J, Luo M, Zhang Z, Liang H. Motivating Physicians to report adverse medical events in China: Stick or Carrot? J Patient Saf. 2021;17(5):e455–61.CrossRefPubMed
9.
Schwendimann R, Blatter C, Dhaini S, Simon M, Ausserhofer D. The occurrence, types, consequences and preventability of in-hospital adverse events - a scoping review. BMC Health Serv Res. 2018;18(1):521.CrossRefPubMedPubMedCentral
10.
Murray CJ, Ezzati M, Flaxman AD, Lim S, Lozano R, Michaud C, Naghavi M, Salomon JA, Shibuya K, Vos T, et al. GBD 2010: design, definitions, and metrics. Lancet. 2012;380(9859):2063–6.CrossRefPubMed
11.
GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the global burden of Disease Study 2016. Lancet. 2017;390(10100):1151–210.CrossRef
12.
GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 Diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of Disease Study 2019. Lancet. 2020;396(10258):1204–22.CrossRef
13.
GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the global burden of Disease Study 2017. Lancet. 2018;392(10159):1736–88.CrossRef
14.
GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of Disease Study 2019. Lancet. 2020;396(10258):1223–49.CrossRef
15.
Li Y, Zhang J. Disease burden and risk factors of Ischemic Heart Disease in China during 1990–2019 based on the global burden of Disease 2019 report: a systematic analysis. Front Public Health. 2022;10:973317.CrossRefPubMedPubMedCentral
16.
17.
Haagsma JA, James SL, Castle CD, Dingels ZV, Fox JT, Hamilton EB, Liu Z, Lucchesi LR, Roberts NLS, Sylte DO, et al. Burden of injury along the development spectrum: associations between the socio-demographic index and disability-adjusted life year estimates from the global burden of Disease Study 2017. Inj Prev. 2020;26(Supp 1):i12–i26.CrossRefPubMed
18.
Xiong R, Bi XY. Analysis and countermeasures of 1, 117 medical adverse events in a certain General Hospital. Jiangsu Healthc Adm 2022, 05.
19.
20.
Zhang D, Unschuld PU. China’s barefoot doctor: past, present, and future. Lancet. 2008;372(9653):1865–7.CrossRefPubMed
21.
Shi L. Health care in China: a rural-urban comparison after the socioeconomic reforms. Bull World Health Organ. 1993;71(6):723–36.PubMedPubMedCentral
22.
Lee K. Health policy in Asia and the Pacific: navigating local needs and global challenges. Asia Pac Policy Stud. 2014;1(1):45–57.CrossRefPubMed
23.
24.
Li X, Zhang S, Chen R, Gu D. Hospital climate and peer report intention on adverse medical events: role of attribution and rewards. Int J Environ Res Public Health 2021, 18(5).
25.
Yip WC, Hsiao WC, Chen W, Hu S, Ma J, Maynard A. Early appraisal of China’s huge and complex health-care reforms. Lancet. 2012;379(9818):833–42.CrossRefPubMed
26.
Yip W, Fu H, Chen AT, Zhai T, Jian W, Xu R, Pan J, Hu M, Zhou Z, Chen Q, et al. 10 years of health-care reform in China: progress and gaps in Universal Health Coverage. Lancet. 2019;394(10204):1192–204.CrossRefPubMed
27.
Williams F, Boren SA. The role of the electronic medical record (EMR) in care delivery development in developing countries: a systematic review. Inf Prim Care. 2008;16(2):139–45.
28.
29.
Jiang F, Jiang Y, Zhi H, Dong Y, Li H, Ma S, Wang Y, Dong Q, Shen H, Wang Y. Artificial intelligence in healthcare: past, present and future. Stroke Vasc Neurol. 2017;2(4):230–43.CrossRefPubMedPubMedCentral
30.
31.
Yi H, Zhang L, Singer K, Rozelle S, Atlas S. Health insurance and catastrophic Illness: a report on the New Cooperative Medical System in rural China. Health Econ. 2009;18(Suppl 2):119–27.
32.
33.
34.
Zopf Y, Rabe C, Neubert A, Janson C, Brune K, Hahn EG, Dormann H. Gender-based differences in drug prescription: relation to adverse drug reactions. Pharmacology. 2009;84(6):333–9.CrossRefPubMed
35.
McCauley M, Zafar S, van den Broek N. Maternal multimorbidity during pregnancy and after Childbirth in women in low- and middle-income countries: a systematic literature review. BMC Pregnancy Childbirth. 2020;20(1):637.CrossRefPubMedPubMedCentral
36.
Chen Z, Peto R, Zhou M, Iona A, Smith M, Yang L, Guo Y, Chen Y, Bian Z, Lancaster G, et al. Contrasting male and female trends in tobacco-attributed mortality in China: evidence from successive nationwide prospective cohort studies. Lancet. 2015;386(10002):1447–56.CrossRefPubMedPubMedCentral
37.
Hesselbrock MN, Hesselbrock VM, Chan G, Del Boca F, Chartier K. Subtypes of Alcohol Dependence and 36-Year mortality. Alcohol Clin Exp Res. 2020;44(8):1658–65.CrossRefPubMedPubMedCentral
38.
39.
Kaushal R, Bates DW, Landrigan C, McKenna KJ, Clapp MD, Federico F, Goldmann DA. Medication errors and adverse drug events in pediatric inpatients. JAMA. 2001;285(16):2114–20.CrossRefPubMed
40.
Szlejf C, Farfel JM, Curiati JA, Couto Ede B Jr., Jacob-Filho W, Azevedo RS. Medical adverse events in elderly hospitalized patients: a prospective study. Clin (Sao Paulo). 2012;67(11):1247–52.CrossRef
41.
Leape LL, Brennan TA, Laird N, Lawthers AG, Localio AR, Barnes BA, Hebert L, Newhouse JP, Weiler PC, Hiatt H. The nature of adverse events in hospitalized patients. Results of the Harvard Medical Practice Study II. N Engl J Med. 1991;324(6):377–84.CrossRefPubMed
Metadata
Title
Global trends and partial forecast of adverse effects of medical treatment from 1990 to 2019: an epidemiological analysis based on the global burden of disease study 2019
Authors
Xin Kong
Xufeng Tao
Lu Li
Xinya Zhao
Jiaqi Ren
Shilei Yang
Xuyang Chen
Hong Xiang
Guoyu Wu
Yunming Li
Deshi Dong
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2024
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-023-17560-0

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