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01-02-2017 | Original Article

Global Deformation Parameters Response to Exercise in Adolescents with Repaired Tetralogy of Fallot

Authors: Timur Mese, Baris Guven, Murat Muhtar Yilmazer, Mustafa Demirol, Şenay Çoban, Cem Karadeniz

Published in: Pediatric Cardiology | Issue 2/2017

Abstract

Exercise stress echocardiography is rarely used in the follow-up of children with congenital heart disease following surgical repair. There are no data on global longitudinal strain (GLS) and global circumferential strain (GCS) during exercise in adolescents with repaired tetralogy of Fallot (TOF). The purpose of this prospective study was to investigate GLS and GCS using speckle tracking two-dimensional echocardiography (2D-STE) at rest and during exercise in adolescents with repaired TOF. Twenty patients with repaired TOF and 20 controls were included. The subjects exercised on a semi-supine cycle ergometer using a two-staged 3-min step protocol of 20–40 W at 60–75 rpm. Exercise images with 2D-STE measurements were available for all 40 subjects. In the study group, the GLS values changed significantly between the baseline and third and sixth minute of exercise (−18.10 ± 2.20, −16.23 ± 4.47, −14.22 ± 2.63, respectively, p < 001). GCS did not vary significantly from baseline to end of the exercise testing (−17.49 ± 5.14, −17.15 ± 9.20, −15.66 ± 3.59, respectively, p > 0.05). There was a statistically significant difference between the Stage I longitudinal strain values of the study and control groups (−14.26 ± 9.13 and −20.22 ± 2.88, respectively, p = 0.02) but no significant difference between the Stage II values of these groups (−14.22 ± 2.63 and −15.11 ± 2.45, respectively, p > 0.05). The results revealed significant changes in GLS during exercise in patients with repaired TOF. Data gathered from deformation analysis of 2D-STE during exercise testing can enhance the ability to detect subtle ventricular dysfunction in the follow-up of children with repaired TOF.

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Title: Global Deformation Parameters Response to Exercise in Adolescents with Repaired Tetralogy of Fallot
Authors: Timur Mese
Baris Guven
Murat Muhtar Yilmazer
Mustafa Demirol
Şenay Çoban
Cem Karadeniz
Publication date: 01-02-2017
Publisher: Springer US
Published in: Pediatric Cardiology / Issue 2/2017
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-016-1522-4

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