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Open Access 01-12-2023 | Glioma | Case report

A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis

Authors: A. Kaywan Aftahy, Vicki M. Butenschoen, Lisa Hoenikl, Friederike Liesche-Starnecker, Benedikt Wiestler, Friederike Schmidt-Graf, Bernhard Meyer, Jens Gempt

Published in: BMC Neurology | Issue 1/2023

Abstract

Background

H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses.

Case presentation

We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented with back pain, hemi-hypoesthesia, and hemi-hyperhidrosis. The patient underwent combined radio-chemotherapy and demonstrated temporary improvement before deteriorating.

Conclusions

H3K27-altered diffuse midline glioma presents an infrequent but crucial differential diagnosis and should be considered in cases with rapid neurological deterioration and multiple intracranial and intramedullary tumor lesions in children and young adults. Combined radio-chemotherapy delayed the neurological deterioration, but unfortunately, progression occurred three months after the diagnosis.

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Title: A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis
Authors: A. Kaywan Aftahy
Vicki M. Butenschoen
Lisa Hoenikl
Friederike Liesche-Starnecker
Benedikt Wiestler
Friederike Schmidt-Graf
Bernhard Meyer
Jens Gempt
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Glioma
Metastasis
Hyperhidrosis
Glioma
Glioma
Published in: BMC Neurology / Issue 1/2023
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-023-03135-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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