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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-02-2022 | Glioma | Research Article

Repeatability of perfusion measurements in adult gliomas using pulsed and pseudo-continuous arterial spin labelling MRI

Authors: Amirah Faisal Alsaedi, David Lee Thomas, Enrico De Vita, Jasmina Panovska-Griffiths, Sotirios Bisdas, Xavier Golay

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2022

Abstract

Objectives

To investigate the repeatability of perfusion measures in gliomas using pulsed- and pseudo-continuous-arterial spin labelling (PASL, PCASL) techniques, and evaluate different regions-of-interest (ROIs) for relative tumour blood flow (rTBF) normalisation.

Materials and methods

Repeatability of cerebral blood flow (CBF) was measured in the Contralateral Normal Appearing Hemisphere (CNAH) and in brain tumours (aTBF). rTBF was normalised using both large/small ROIs from the CNAH. Repeatability was evaluated with intra-class-correlation-coefficient (ICC), Within-Coefficient-of-Variation (WCoV) and Coefficient-of-Repeatability (CR).

Results

PASL and PCASL demonstrated high reliability (ICC > 0.9) for CNAH-CBF, aTBF and rTBF. PCASL demonstrated a more stable signal-to-noise ratio (SNR) with a lower WCoV of the SNR than that of PASL (10.9–42.5% vs. 12.3–29.2%). PASL and PCASL showed higher WCoV in aTBF and rTBF than in CNAH CBF in WM and GM but not in the caudate, and higher WCoV for rTBF than for aTBF when normalised using a small ROI (PASL 8.1% vs. 4.7%, PCASL 10.9% vs. 7.9%, respectively). The lowest CR was observed for rTBF normalised with a large ROI.

Discussion

PASL and PCASL showed similar repeatability for the assessment of perfusion parameters in patients with primary brain tumours as previous studies based on volunteers. Both methods displayed reasonable WCoV in the tumour area and CNAH. PCASL’s more stable SNR in small areas (caudate) is likely to be due to the longer post-labelling delays.

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Title: Repeatability of perfusion measurements in adult gliomas using pulsed and pseudo-continuous arterial spin labelling MRI
Authors: Amirah Faisal Alsaedi
David Lee Thomas
Enrico De Vita
Jasmina Panovska-Griffiths
Sotirios Bisdas
Xavier Golay
Publication date: 01-02-2022
Publisher: Springer International Publishing
Keywords: Glioma
Glioma
Glioma
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2022
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-021-00975-4

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Repeatability of perfusion measurements in adult gliomas using pulsed and pseudo-continuous arterial spin labelling MRI

Abstract

Objectives

Materials and methods

Results

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Discussion

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