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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 01-02-2022 | Glioma | Research Article

3D APT and NOE CEST-MRI of healthy volunteers and patients with non-enhancing glioma at 3 T

Authors: Yulun Wu, Tobias C. Wood, Fatemeh Arzanforoosh, Juan A. Hernandez-Tamames, Gareth J. Barker, Marion Smits, Esther A. H. Warnert

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2022

Abstract

Objective

Clinical application of chemical exchange saturation transfer (CEST) can be performed with investigation of amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) effects. Here, we investigated APT- and NOE-weighted imaging based on advanced CEST metrics to map tumor heterogeneity of non-enhancing glioma at 3 T.

Materials and methods

APT- and NOE-weighted maps based on Lorentzian difference (LD) and inverse magnetization transfer ratio (MTR_REX) were acquired with a 3D snapshot CEST acquisition at 3 T. Saturation power was investigated first by varying B₁ (0.5–2 µT) in 5 healthy volunteers then by applying B₁ of 0.5 and 1.5 µT in 10 patients with non-enhancing glioma. Tissue contrast (TC) and contrast-to-noise ratios (CNR) were calculated between glioma and normal appearing white matter (NAWM) and grey matter, in APT- and NOE-weighted images. Volume percentages of the tumor showing hypo/hyperintensity (VP_{hypo/hyper,CEST}) in APT/NOE-weighted images were calculated for each patient.

Results

LD APT resulting from using a B₁ of 1.5 µT was found to provide significant positive TC_tumor,NAWM and MTR_REX NOE (B₁ of 1.5 µT) provided significant negative TC_tumor,NAWM in tissue differentiation. MTR_REX-based NOE imaging under 1.5 µT provided significantly larger VP_hypo,CEST than MTR_REX APT under 1.5 µT.

Conclusion

This work showed that with a rapid CEST acquisition using a B₁ saturation power of 1.5 µT and covering the whole tumor, analysis of both LD APT and MTR_REX NOE allows for observing tumor heterogeneity, which will be beneficial in future studies using CEST-MRI to improve imaging diagnostics for non-enhancing glioma.

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Title: 3D APT and NOE CEST-MRI of healthy volunteers and patients with non-enhancing glioma at 3 T
Authors: Yulun Wu
Tobias C. Wood
Fatemeh Arzanforoosh
Juan A. Hernandez-Tamames
Gareth J. Barker
Marion Smits
Esther A. H. Warnert
Publication date: 01-02-2022
Publisher: Springer International Publishing
Keywords: Glioma
Glioma
Glioma
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2022
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-021-00996-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

3D APT and NOE CEST-MRI of healthy volunteers and patients with non-enhancing glioma at 3 T

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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