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Published in: Neuroradiology 8/2021

01-08-2021 | Glioma | Review

Radiohistogenomics of pediatric low-grade neuroepithelial tumors

Authors: Asim K. Bag, Jason Chiang, Zoltan Patay

Published in: Neuroradiology | Issue 8/2021

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Abstract

Purpose

In addition to histology, genetic alteration is now required to classify many central nervous system (CNS) tumors according to the most recent World Health Organization CNS tumor classification scheme. Although that is still not the case for classifying pediatric low-grade neuroepithelial tumors (PLGNTs), genetic and molecular features are increasingly being used for making treatment decisions. This approach has become a standard clinical practice in many specialized pediatric cancer centers and will likely be more widely practiced in the near future. This paradigm shift in the management of PLGNTs necessitates better understanding of how genetic alterations influence histology and imaging characteristics of individual PLGNT phenotypes.

Methods

The complex association of genetic alterations with histology, clinical, and imaging of each phenotype of the extremely heterogeneous PLGNT family has been addressed in a holistic approach in this up-to-date review article. A new imaging stratification scheme has been proposed based on tumor morphology, location, histology, and genetics. Imaging characteristics of each PLGNT entity are also depicted in light of histology and genetics.

Conclusion

This article reviews the association of specific genetic alteration with location, histology, imaging, and prognosis of a specific tumor of the PLGNT family and how that information can be used for better imaging of these tumors.
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Metadata
Title
Radiohistogenomics of pediatric low-grade neuroepithelial tumors
Authors
Asim K. Bag
Jason Chiang
Zoltan Patay
Publication date
01-08-2021
Publisher
Springer Berlin Heidelberg
Published in
Neuroradiology / Issue 8/2021
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-021-02691-1

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