Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Acta Neurochirurgica
Published in: Acta Neurochirurgica 4/2023

08-12-2022 | Glioma | How I Do it - Brain Tumors

Endoscopic transventricular biopsy in brainstem diffuse midline glioma: how I do it

Authors: Emanuele La Corte, Micol Babini, Giada Bortoluzzi, Mino Zucchelli

Published in: Acta Neurochirurgica | Issue 4/2023

Login to get access

Abstract

Background

Brainstem diffuse midline gliomas represent infiltrative and rare pediatric tumors with a dismal prognosis. Surgical biopsy is emerging as a valid technique to define diagnosis and molecular markers for future targeted therapies.

Method

We describe the key steps of an endoscopic trans-ventricular biopsy of a brainstem diffuse midline glioma and associated ventriculomegaly. The relevant surgical anatomy along with an illustrative video is described.

Conclusion

The endoscopic third ventriculostomy combined with a punch biopsy of a brainstem diffuse midline glioma associated with ventriculomegaly represent a feasible and low-risk procedure to simultaneously treat incipient hydrocephalus and molecular diagnosis for future treatment and research.
Appendix
Available only for authorised users
Literature
1.
Fonseca A, Solano P, Ramaswamy V et al (2021) Ventricular size determination and management of ventriculomegaly and hydrocephalus in patients with diffuse intrinsic pontine glioma: an institutional experience. J Neurosurg 135(4):1139–1145CrossRef
2.
Giussani C, Guida L, Biassoni V, Schiavello E, Carrabba G, Trezza A, Sganzerla E, Massimino M (2020) Retrospective analysis of the clinical and radiological features of 94 consecutive DIPGs patients to investigate the factors determining the development of hydrocephalus and its impact on clinical status and survival. Child’s Nerv Syst 36(11):2701–2705CrossRef
3.
Guida L, Roux FE, Massimino M, Marras CE, Sganzerla E, Giussani C (2019) Safety and efficacy of endoscopic third ventriculostomy in diffuse intrinsic pontine glioma related hydrocephalus: a systematic review. World Neurosurg 124:29–35CrossRef
4.
Gupta N, Goumnerova LC, Manley P et al (2018) Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma. Neuro Oncol 20(11):1547–1555CrossRefPubMedPubMedCentral
5.
Kobayashi N, Ogiwara H (2016) Endoscopic third ventriculostomy for hydrocephalus in brainstem glioma: a case series. Child’s Nerv Syst 32(7):1251–1255CrossRef
6.
Louis DN, Perry A, Wesseling P et al (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23(8):1231–1251CrossRefPubMedPubMedCentral
7.
Massimino M, Biassoni V, Miceli R et al (2014) Results of nimotuzumab and vinorelbine, radiation and re-irradiation for diffuse pontine glioma in childhood. J Neurooncol 118(2):305–312PubMed
8.
Naftel RP, Shannon CN, Reed GT, Martin R, Blount JP, Tubbs RS, Wellons JC (2011) Small-ventricle neuroendoscopy for pediatric brain tumor management: clinical article. J Neurosurg Pediatr 7(1):104–110CrossRefPubMed
9.
Oertel J, Linsler S, Csokonay A, Schroeder HWS, Senger S (2019) Management of severe intraoperative hemorrhage during intraventricular neuroendoscopic procedures: the dry field technique. J Neurosurg 131(3):931–935CrossRef
10.
Puget S, Beccaria K, Blauwblomme T, Roujeau T, James S, Grill J, Zerah M, Varlet P, Sainte-Rose C (2015) Biopsy in a series of 130 pediatric diffuse intrinsic Pontine gliomas. Child’s Nerv Syst 31(10):1773–1780CrossRef
11.
Williams JR, Young CC, Vitanza NA, Mcgrath M, Feroze AH, Browd SR, Hauptman JS (2020) Progress in diffuse intrinsic pontine glioma: advocating for stereotactic biopsy in the standard of care. Neurosurg Focus 48(1):1–8CrossRef
Metadata
Title
Endoscopic transventricular biopsy in brainstem diffuse midline glioma: how I do it
Authors
Emanuele La Corte
Micol Babini
Giada Bortoluzzi
Mino Zucchelli
Publication date
08-12-2022
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 4/2023
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-022-05443-z

Other articles of this Issue 4/2023

Acta Neurochirurgica 4/2023 Go to the issue

Original Article - Spine - Other

Emergency surgical decompression for spontaneous spinal epidural hematoma in octogenarians: risk factors, clinical outcomes, and complications

Original Article - Functional Neurosurgery - Other

Increased cerebrospinal fluid S100B protein levels in patients with trigeminal neuralgia and hemifacial spasm

Original Article - Tumor - Other

When is a staging scan required for newly diagnosed brain lesions on CT? A multivariate logistic regression analysis

Original Article

Coping strategies in patients with good outcome but chronic fatigue after aneurysmal subarachnoid hemorrhage

Original Article - Neurosurgery general

Personalized surgical informed consent with stereoscopic visualization in neurosurgery—real benefit for the patient or unnecessary gimmick?

Original Article

Profound prospective assessment of radiological and functional outcome 6 months after TBI in elderly