Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Acta Neurochirurgica
Published in: Acta Neurochirurgica 4/2023

02-12-2022 | Trigeminal Neuralgia | Original Article - Functional Neurosurgery - Other

Increased cerebrospinal fluid S100B protein levels in patients with trigeminal neuralgia and hemifacial spasm

Authors: Eiji Ito, Yukio Seki, Kiyoshi Saito, Ryuta Saito

Published in: Acta Neurochirurgica | Issue 4/2023

Login to get access

Abstract

Background

The pathophysiology of neurovascular compression syndrome has not been fully elucidated, and cerebrospinal fluid levels of nerve tissue-related markers involved in this disorder have not yet been reported.

Methods

We measured cerebrospinal fluid levels of S100B protein, neuron-specific enolase, and myelin basic protein in 21 patients with trigeminal neuralgia, 9 patients with hemifacial spasms, and 10 patients with non-ruptured intracranial aneurysms (control). Cerebrospinal fluid levels of these markers were determined using commercially available assay kits.

Results

Both trigeminal neuralgia and hemifacial spasm groups showed significantly increased cerebrospinal fluid levels of S100B compared with the control group (1120 [IQR 391–1420], 766 [IQR 583–1500], and 255 [IQR 190–285] pg/mL, respectively; p = 0.001). There were no statistically significant differences in cerebrospinal fluid levels of neuron-specific enolase or myelin basic protein among the groups.

Conclusion

Cerebrospinal fluid S100B levels were significantly higher in patients with trigeminal neuralgia and hemifacial spasm than in controls, which suggests the involvement of S100B in the underlying pathophysiology of neurovascular compression syndrome.
Literature
1.
An JX et al (2011) A new animal model of trigeminal neuralgia produced by administration of cobra venom to the infraorbital nerve in the rat. Anesth Analg 113:652–656CrossRefPubMed
2.
Arrais AC et al (2022) S100B protein: general characteristics and pathophysiological implications in the Central Nervous System. Int J Neurosci 132:313–321CrossRefPubMed
3.
Brisby H, Olmarker K, Rosengren L, Cederlund CG, Rydevik B (1999) Markers of nerve tissue injury in the cerebrospinal fluid in patients with lumbar disc herniation and sciatica. Spine (Phila. Pa) 24:742–746CrossRef
4.
Campos-Benitez M, Kaufmann AM (2008) Neurovascular compression findings in hemifacial spasm. J Neurosurg 109:416–420CrossRefPubMed
5.
Chabok SY et al (2012) Neuron-specific enolase and S100BB as outcome predictors in severe diffuse axonal injury. J Trauma Acute Care Surg 72:1654–1657CrossRefPubMed
6.
Donato R (2003) Intracellular and extracellular roles of S100 proteins. Microsc Res Tech 60:540–551CrossRefPubMed
7.
8.
Gerlach R et al (2006) Active secretion of S100B from astrocytes during metabolic stress. Neuroscience 141:1697–1701CrossRefPubMed
9.
Gonzalez LL, Garrie K, Turner MD (2020) Role of S100 proteins in health and disease. Biochim Biophys Acta Mol. Cell Res 1867:32057918CrossRef
10.
11.
Guclu B et al (2011) Cranial nerve vascular compression syndromes of the trigeminal, facial and vago-glossopharyngeal nerves: Comparative anatomical study of the central myelin portion and transitional zone; Correlations with incidences of corresponding hyperactive dysfunctio. Acta Neurochir (Wien) 153:2365–2375CrossRefPubMed
12.
Haque A, Polcyn R, Matzelle D, Banik NL (2018) New insights into the role of neuron-specific enolase in neuro-inflammation, neurodegeneration, and neuroprotection. Brain Sci 8:1–2CrossRef
13.
Hofmann MA et al (1999) RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 97:889–901CrossRefPubMed
14.
Huttunen HJ et al (2000) Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation. J Biol Chem 275:40096–40105CrossRefPubMed
15.
Huttunen HJ, Fages C, Rauvala H (1999) Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J Biol Chem 274:19919–19924CrossRefPubMed
16.
Jannetta PJ (1967) Arterial compression of the trigeminal nerve at the pons in patients with trigeminal neuralgia. J Neurosurg 26:159–162CrossRef
17.
Kligman D, Marshak DR (1985) Purification and characterization of a neurite extension factor from bovine brain. Proc Natl Acad Sci USA 82:7136–7139CrossRefPubMedPubMedCentral
18.
Kuroki A, Møller AR (1994) Facial nerve demyelination and vascular compression are both needed to induce facial hyperactivity: a study in rats. Acta Neurochir (Wien) 126:149–157CrossRefPubMed
19.
Langeh U, Singh S (2020) Targeting S100B protein as a surrogate biomarker and its role in various neurological disorders. Curr Neuropharmacol 19:265–277CrossRef
20.
Leclerc E, Fritz G, Weibel M, Heizmann CW, Galichet A (2007) S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains. J Biol Chem 282:31317–31331CrossRefPubMed
21.
Leung Brain K et al (2012) Basic Science An Animal Model for Trigeminal Neuralgia by Compression of the Trigeminal Nerve Root. Pain Physician 15:187–196
22.
Maiti R et al (2018) Effect of anti-seizure drugs on serum S100B in patients with focal seizure: a randomized controlled trial. J Neurol 265:2594–2601CrossRefPubMed
23.
Michetti F et al (2019) The S100B story: from biomarker to active factor in neural injury. J Neurochem 148:168–187CrossRefPubMed
24.
Missler U, Wiesmann M, Friedrich C, Kaps M (1997) S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke 28:1956–1960CrossRefPubMed
25.
Noga MJ et al (2012) Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis. Metabolomics 8:253–263CrossRefPubMed
26.
Perrone L, Peluso G, Melone MAB (2008) RAGE recycles at the plasma membrane in S100B secretory vesicles and promotes Schwann cells morphological changes. J Cell Physiol 217:60–71CrossRefPubMed
27.
Riehl A, Németh J, Angel P, Hess J (2009) The receptor RAGE: bridging inflammation and cancer. Cell Commun Signal 7:8–9CrossRef
28.
Rong LL et al (2004) Antagonism of RAGE suppresses peripheral nerve regeneration. FASEB J 18:1812–1817CrossRefPubMed
29.
Sakatani S et al (2008) Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gmma oscillations in vivo. J Neurosci 28:10928–10936CrossRefPubMedPubMedCentral
30.
Selinfreund RH, Barger SW, Pledger WJ, Van Eldik LJ (1991) Neurotrophic protein S100β stimulates glial cell proliferation. Proc Natl Acad Sci U S A 88:3554–3558CrossRefPubMedPubMedCentral
31.
Shashoua VE, Hesse GW, Moore BW (1984) Proteins of the brain extracellular fluid: evidence for release of S-100 protein. J Neurochem 42:1536–1541CrossRefPubMed
32.
Sindou MP (2005) Microvascular decompression for primary hemifacial spasm. Importance of intraoperative neurophysiological monitoring. Acta Neurochir (Wien) 147:1019–1026CrossRefPubMed
33.
Sindou M, Keravel Y (2009) Traitement neurochirurgical du spasme hémifacial primaire par décompression vasculaire microchirurgicale. Neurochirurgie 55:236–247CrossRefPubMed
34.
Sindou M, Leston J, Decullier E, Chapuis F (2007) Microvascular decompression for primary trigeminal neuralgia: Long-term effectiveness and prognostic factors in a series of 362 consecutive patients with clear-cut neurovascular conflicts who underwent pure decompression. J Neurosurg 107:1144–1153CrossRefPubMed
35.
Sindou M, Howeidycevedo T, GAcevedo G (2022) Anatomical observations during microvascular decompression for idiopathic trigeminal neuralgia ( with correlations between topography of pain and site of the neurovascular conflict). Prospect Stud Ser Patients 579 144:1–2
36.
Sorci G, Riuzzi F, Agneletti AL, Marchetti C, Donato R (2004) S100B Causes apoptosis in a myoblast cell line in a RAGE-independent manner. J Cell Physiol 199:274–283CrossRefPubMed
37.
Steiner J et al (2008) S100B is expressed in, and released from, OLN-93 oligodendrocytes: Influence of serum and glucose deprivation. Neuroscience 154:496–503CrossRefPubMed
38.
Van Eldik LJ, Zimmer DB (1987) Secretion of S-100 from rat C6 glioma cells. Brain Res 436:367–370CrossRefPubMed
39.
Wang L et al (2020) Trigeminal neuralgia causes neurodegeneration in rats associated with upregulation of the CD95/CD95L pathway. Mol Pain 16:1–14CrossRef
Metadata
Title
Increased cerebrospinal fluid S100B protein levels in patients with trigeminal neuralgia and hemifacial spasm
Authors
Eiji Ito
Yukio Seki
Kiyoshi Saito
Ryuta Saito
Publication date
02-12-2022
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 4/2023
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-022-05434-0

Other articles of this Issue 4/2023

Acta Neurochirurgica 4/2023 Go to the issue

Original Article

Butterfly needle tap and suction (BTS) technique: a treatment for recurrent chronic subdural hematoma after burr hole craniostomy

Original Article - Vascular Neurosurgery - Arteriovenous malformation

External validation of the Ruptured Arteriovenous Malformation Grading Scale (RAGS) in a multicenter adult cohort

Editorial (by Invitation)

The clinical and ethical challenges of treating comatose patients following severe brain injury

How I Do It - Functional Neurosurgery - Pain

Microsurgical DREZotomy for pain related to Pancoast-Tobias syndrome: how I do it?

Original Article - Peripheral Nerves

Hybrid tumors with perineurioma components: a systematic review of the literature and illustrative case

Editorial (by Invitation)

Surgical treatment of cervical epidural abscess in the very elderly