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01-05-2019 | Glioblastoma | Clinical Study

Impact on survival of early tumor growth between surgery and radiotherapy in patients with de novo glioblastoma

Authors: Amaury De Barros, Justine Attal, Margaux Roques, Julien Nicolau, Jean-Christophe Sol, Elizabeth Cohen-Jonathan-Moyal, Franck-Emmanuel Roux

Published in: Journal of Neuro-Oncology | Issue 3/2019

Abstract

Purpose

Systematic pre-radiotherapy MRI in patients with newly resected glioblastoma (OMS 2016) sometimes reveals tumor growth in the period between surgery and radiotherapy. We evaluated the relation between early tumor growth and overall survival (OS) with the aim of finding predictors of regrowth.

Methods

Seventy-five patients from 25 to 84 years old (Median age 62 years) with preoperative, immediate postoperative, and preradiotherapy MRI were included. Volumetric measurements were made on each of the three MRI scans and clinical and molecular parameters were collected for each case.

Results

Fifty-four patients (72%) had an early regrowth with a median contrast enhancement volume of 3.61 cm³—range 0.12–71.93 cm³. The median OS was 24 months in patients with no early tumor growth and 17.1 months in those with early tumor regrowth (p = 0.0024). In the population with initial complete resection (27 patients), the median OS was 25.3 months (19 patients) in those with no early tumor growth between surgery and radiotherapy compared to 16.3 months (8 patients) in those with tumor regrowth. In multivariate analysis, the initial extent of resection (p < 0.001) and the delay between postoperative MRI and preradiotherapy MRI (p < 0.001) were significant independent prognostic factors of regrowth and of poorer outcome.

Conclusions

We demonstrated that, in addition to the well known issue of incomplete resection, longer delays between surgery and adjuvant treatment is an independent factors of tumor regrowth and a risk factor of poorer outcomes for the patients. To overcome the delay factor, we suggest shortening the usual time between surgery and radiotherapy.

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Title: Impact on survival of early tumor growth between surgery and radiotherapy in patients with de novo glioblastoma
Authors: Amaury De Barros
Justine Attal
Margaux Roques
Julien Nicolau
Jean-Christophe Sol
Elizabeth Cohen-Jonathan-Moyal
Franck-Emmanuel Roux
Publication date: 01-05-2019
Publisher: Springer US
Keywords: Glioblastoma
Glioblastoma
Radiotherapy
Glioblastoma
Published in: Journal of Neuro-Oncology / Issue 3/2019
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-019-03120-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact on survival of early tumor growth between surgery and radiotherapy in patients with de novo glioblastoma

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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