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Published in:

01-07-2015 | Editors' Invited Manuscript

Glioblastoma stem cells and stem cell-targeting immunotherapies

Authors: Rogelio Esparza, Tej D. Azad, Abdullah H. Feroze, Siddhartha S. Mitra, Samuel H. Cheshier

Published in: Journal of Neuro-Oncology | Issue 3/2015

Abstract

Advancements in immunotherapeutics promise new possibilities for the creation of glioblastoma (GBM) treatment options. Ongoing work in cancer stem cell biology has progressively elucidated the role of this tumor sub-population in oncogenesis and has distinguished them as prime therapeutic targets. Current clinical trials take a multifaceted approach with the intention of harnessing the intrinsic cytotoxic capabilities of the immune system to directly target glioblastoma cancer stem cells (gCSC) or indirectly disrupt their stromal microenvironment. Monoclonal antibodies (mAbs), dendritic cell (DC) vaccines, and chimeric antigen receptor (CAR) T cell therapies have emerged as the most common approaches, with particular iterations incorporating cancer stem cell antigenic markers in their treatment designs. Ongoing work to determine the comprehensive antigenic profile of the gCSC in conjunction with efforts to counter the immunosuppressive tumor microenvironment holds much promise in future immunotherapeutic strategies against GBM. Given recent advancements in these fields, we believe there is tremendous potential to improve outcomes of GBM patients in the continuing evolution of immunotherapies targeted to cancer stem cell populations in GBM.

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Title: Glioblastoma stem cells and stem cell-targeting immunotherapies
Authors: Rogelio Esparza
Tej D. Azad
Abdullah H. Feroze
Siddhartha S. Mitra
Samuel H. Cheshier
Publication date: 01-07-2015
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2015
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-015-1729-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Glioblastoma stem cells and stem cell-targeting immunotherapies

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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