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Published in: International Ophthalmology 1/2024

01-12-2024 | Glaucoma | Original Paper

Migraine headache and other risk factors associated with glaucoma among the adult population living in Armenia: a case–control study

Authors: Aida Giloyan, Vahe Khachadourian, Varsik Hakobyan, Lilit Kirakosyan, Varduhi Petrosyan, Tsovinar Harutyunyan

Published in: International Ophthalmology | Issue 1/2024

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Abstract

Purpose

This study aimed to assess the association between migraine headache and glaucoma among the adult population living in Armenia.

Methods

This case–control study recruited 145 cases with glaucoma and 250 controls without glaucoma and other ocular disorders except refractive error from Optomed Canada Diagnostic Eye Center in Armenia. A structured questionnaire contained questions on socio-demographics, family history of glaucoma and stroke, ocular health, smoking, migraine, and obstructive sleep apnea. The Migraine Screening Questionnaire assessed possible migraine and the Berlin Questionnaire measured obstructive sleep apnea.

Results

The mean ages of cases and controls were 63.3 (SD = 12.3) and 39.5 (SD = 13.5), respectively. Females comprised 62.8% of cases and 69.1% of controls. A total of 17.8% of cases and 19.0% of controls had possible migraine. In the adjusted analysis older age (OR 1.17; 95% CI 1.12; 1.23), average/lower than average socio-economic status (OR 5.27; 95% CI 1.30; 21.3), and family history of glaucoma (OR 4.25; 95% CI 1.51; 11.9) were associated with high-tension glaucoma.

Conclusion

Timely case detection of glaucoma among those with average/low socio-economic status and those with family history of glaucoma could prevent further progression of the disease. Further studies to explore the relationship between migraine headache and specific types of glaucoma may be worthwhile.
Appendix
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Literature
1.
go back to reference Tham YC, Li X, Wong TY, Quigley H, Aung T, Cheng CY (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis. Ophthalmology 121(11):2081–2090PubMedCrossRef Tham YC, Li X, Wong TY, Quigley H, Aung T, Cheng CY (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis. Ophthalmology 121(11):2081–2090PubMedCrossRef
3.
go back to reference Láinez MJ, Castillo J, Domínguez M, Palacios G, Díaz S, Rejas J (2010) New uses of the Migraine Screen Questionnaire (MS-Q): validation in the primary care setting and ability to detect hidden migraine. MS-Q in Primary Care BMC Neurol 10(1):39PubMed Láinez MJ, Castillo J, Domínguez M, Palacios G, Díaz S, Rejas J (2010) New uses of the Migraine Screen Questionnaire (MS-Q): validation in the primary care setting and ability to detect hidden migraine. MS-Q in Primary Care BMC Neurol 10(1):39PubMed
4.
go back to reference Lipton RB, Steward WF, Diamond S, Diamond ML, Reed M (2001) Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 41:416 Lipton RB, Steward WF, Diamond S, Diamond ML, Reed M (2001) Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 41:416
6.
go back to reference Phelps CD, Corbett JJ (1985) Migraine and low-tension glaucoma. A case-control study. Invest Ophthalmol Vis Sci 26:1105–1108PubMed Phelps CD, Corbett JJ (1985) Migraine and low-tension glaucoma. A case-control study. Invest Ophthalmol Vis Sci 26:1105–1108PubMed
7.
go back to reference Cursiefen C, Wisse M, Cursiefen S, Jünemann A, Martus P, Korth M (2000) Migraine and tension headache in high-pressure and normal-pressure glaucoma. Am J Opthalmology 129(1):102–104CrossRef Cursiefen C, Wisse M, Cursiefen S, Jünemann A, Martus P, Korth M (2000) Migraine and tension headache in high-pressure and normal-pressure glaucoma. Am J Opthalmology 129(1):102–104CrossRef
8.
go back to reference Wang JJ, Mitchell P, Smith W (1997) Is there an association between migraine headache and open-angle glaucoma? Findings from the Blue Mountains Eye Study. Opthalmology 104(10):1714–1719CrossRef Wang JJ, Mitchell P, Smith W (1997) Is there an association between migraine headache and open-angle glaucoma? Findings from the Blue Mountains Eye Study. Opthalmology 104(10):1714–1719CrossRef
9.
go back to reference Orgül S, Flammer J (1994) Headache in normal-tension glaucoma patients. J Glaucoma 3(4):292–295PubMed Orgül S, Flammer J (1994) Headache in normal-tension glaucoma patients. J Glaucoma 3(4):292–295PubMed
10.
go back to reference Chen HY, Lin CL, Kao CH (2016) Does migraine increase the risk of glaucoma? A population-based cohort study. Med Baltim 95(19):e3670CrossRef Chen HY, Lin CL, Kao CH (2016) Does migraine increase the risk of glaucoma? A population-based cohort study. Med Baltim 95(19):e3670CrossRef
11.
go back to reference Lewis RA, Vijayan N, Watson C, Keltner J, Johnson CA (1989) Visual field loss in migraine. Ophthalmology 96:321–326PubMedCrossRef Lewis RA, Vijayan N, Watson C, Keltner J, Johnson CA (1989) Visual field loss in migraine. Ophthalmology 96:321–326PubMedCrossRef
12.
go back to reference Gasser P, Meienberg O (1991) Finger microcirculation in classical migraine. A video microscopic study of nailfold capillaries. Eur Neurol 31:168–171PubMedCrossRef Gasser P, Meienberg O (1991) Finger microcirculation in classical migraine. A video microscopic study of nailfold capillaries. Eur Neurol 31:168–171PubMedCrossRef
13.
go back to reference Armaly MF, Krueger DE, Maunder L, Becker B, Hetherington J Jr, Kolker AE, Levene RZ, Maumenee AE, Pollack IP, Shaffer RN (1980) Biostatistical analysis of the collaborative glaucoma study, I: Summary report of the risk factors for glaucomatous visual-field defects. Arch Ophthalmol 98(12):2163–2171PubMedCrossRef Armaly MF, Krueger DE, Maunder L, Becker B, Hetherington J Jr, Kolker AE, Levene RZ, Maumenee AE, Pollack IP, Shaffer RN (1980) Biostatistical analysis of the collaborative glaucoma study, I: Summary report of the risk factors for glaucomatous visual-field defects. Arch Ophthalmol 98(12):2163–2171PubMedCrossRef
14.
go back to reference Leske MC, Wu SY, Hennis A, Honkanen R, Nemesure B (2008) Risk factors for incident open-angle glaucoma: The Barbados Eye Studies. Ophthalmology 115(1):85–93PubMedCrossRef Leske MC, Wu SY, Hennis A, Honkanen R, Nemesure B (2008) Risk factors for incident open-angle glaucoma: The Barbados Eye Studies. Ophthalmology 115(1):85–93PubMedCrossRef
15.
go back to reference Leung DYL, Chan PPM, Tham CCY, Lam DSC (2009) Normal tension glaucoma: risk factors pertaining to a sick eye in a sick body. HKJ Ophthalmol 13(1):15–21 Leung DYL, Chan PPM, Tham CCY, Lam DSC (2009) Normal tension glaucoma: risk factors pertaining to a sick eye in a sick body. HKJ Ophthalmol 13(1):15–21
16.
go back to reference Lin SC, Pasquale LR, Singh K, Lin SC (2018) The Association Between Body Mass Index and open-angle glaucoma in a South Korean population-based sample. J Glaucoma 27(3):239–245PubMedCrossRef Lin SC, Pasquale LR, Singh K, Lin SC (2018) The Association Between Body Mass Index and open-angle glaucoma in a South Korean population-based sample. J Glaucoma 27(3):239–245PubMedCrossRef
17.
go back to reference Shibuya E1, Meguro A, Ota M, Kashiwagi K et al (2008) Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma. Invest Ophthalmol Vis Sci 49(10):4453–4457PubMedCrossRef Shibuya E1, Meguro A, Ota M, Kashiwagi K et al (2008) Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma. Invest Ophthalmol Vis Sci 49(10):4453–4457PubMedCrossRef
18.
go back to reference Collaborative Normal-Tension Glaucoma Study Group (1998) The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am J Ophthalmol 126:498–505CrossRef Collaborative Normal-Tension Glaucoma Study Group (1998) The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am J Ophthalmol 126:498–505CrossRef
19.
go back to reference Chen S-J, Lu P, Zhang W-F, Lu J-H (2012) High myopia as a risk factor in primary open angle glaucoma. Int J Ophthalmol 5(6):750–753PubMedPubMedCentral Chen S-J, Lu P, Zhang W-F, Lu J-H (2012) High myopia as a risk factor in primary open angle glaucoma. Int J Ophthalmol 5(6):750–753PubMedPubMedCentral
20.
go back to reference Mojon DS, Hess CW, Goldblum D, Fleischhauer J, Koerner F, Bassetti C, Mathis J (1999) High prevalence of glaucoma in patients with sleep Apnea syndrome. Ophthalmology 106(5):1009–1012PubMedCrossRef Mojon DS, Hess CW, Goldblum D, Fleischhauer J, Koerner F, Bassetti C, Mathis J (1999) High prevalence of glaucoma in patients with sleep Apnea syndrome. Ophthalmology 106(5):1009–1012PubMedCrossRef
21.
go back to reference Onen SH, Mouriaux F, Berramdane L, Dascotte JC, Kulik JF, Rouland JF (2000) High prevalence of sleep-disordered breathing in patients with primary open-angle glaucoma. Acta Ophthalmol Scand 78(6):638–641PubMedCrossRef Onen SH, Mouriaux F, Berramdane L, Dascotte JC, Kulik JF, Rouland JF (2000) High prevalence of sleep-disordered breathing in patients with primary open-angle glaucoma. Acta Ophthalmol Scand 78(6):638–641PubMedCrossRef
22.
go back to reference Worley A, Grimmer-Somers K (2011) Risk factors for glaucoma: What do they really mean? Aust J Prim Health 17(3):233–239PubMedCrossRef Worley A, Grimmer-Somers K (2011) Risk factors for glaucoma: What do they really mean? Aust J Prim Health 17(3):233–239PubMedCrossRef
23.
go back to reference Zhao YX, Chen XW (2017) Diabetes and risk of glaucoma: systematic review and a meta-analysis of prospective cohort studies. Int J Ophthalmol 10(9):1430–1435PubMedPubMedCentral Zhao YX, Chen XW (2017) Diabetes and risk of glaucoma: systematic review and a meta-analysis of prospective cohort studies. Int J Ophthalmol 10(9):1430–1435PubMedPubMedCentral
24.
25.
go back to reference Fleiss JL (1981) Statistical methods for rates and proportions. Wiley, New Jersey Fleiss JL (1981) Statistical methods for rates and proportions. Wiley, New Jersey
26.
go back to reference Chung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, Islam S, Khajehdehi A, Shapiro CM (2008) Validation of the Berlin questionnaire and American Society of Anesthesiologists checklist as screening tools for obstructive sleep Apnea in surgical patients. Anesthesiology 5:822–830CrossRef Chung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, Islam S, Khajehdehi A, Shapiro CM (2008) Validation of the Berlin questionnaire and American Society of Anesthesiologists checklist as screening tools for obstructive sleep Apnea in surgical patients. Anesthesiology 5:822–830CrossRef
27.
go back to reference Dunn SJ, Brubaker FR (1973) Perkins applanation tonometer clinical and laboratory evaluation. Arch Ophthalmol 89(2):149–151PubMedCrossRef Dunn SJ, Brubaker FR (1973) Perkins applanation tonometer clinical and laboratory evaluation. Arch Ophthalmol 89(2):149–151PubMedCrossRef
28.
go back to reference Mohammadi SF, Mirhadi S, Mehrjardi HZ, Fotouhi A, Vakili STT, Majdi M, Moghimi S (2013) An algorithm for glaucoma screening in clinical settings and its preliminary performance profile. J Ophthalmic Vis Res 8(4):314–320PubMedPubMedCentral Mohammadi SF, Mirhadi S, Mehrjardi HZ, Fotouhi A, Vakili STT, Majdi M, Moghimi S (2013) An algorithm for glaucoma screening in clinical settings and its preliminary performance profile. J Ophthalmic Vis Res 8(4):314–320PubMedPubMedCentral
30.
go back to reference Hosmer DW, Lemeshow S (2000) Applied logistic regression, 2nd edn. A Wiley-Interscience Publication, New YorkCrossRef Hosmer DW, Lemeshow S (2000) Applied logistic regression, 2nd edn. A Wiley-Interscience Publication, New YorkCrossRef
31.
go back to reference Gramer E, Gramer G (2002) Age of the patients at the time of diagnosis in different glaucomas: a prospective study. Invest Ophthalmol Vis Sci 43:3422 Gramer E, Gramer G (2002) Age of the patients at the time of diagnosis in different glaucomas: a prospective study. Invest Ophthalmol Vis Sci 43:3422
32.
go back to reference Drance S, Anderson DR, Schulzer M (2001) Collaborative Normal-Tension Glaucoma Study Group. Risk factors for progression of visual field abnormalities in normal-tension glaucoma. Am J Ophthalmol 131:699–708PubMedCrossRef Drance S, Anderson DR, Schulzer M (2001) Collaborative Normal-Tension Glaucoma Study Group. Risk factors for progression of visual field abnormalities in normal-tension glaucoma. Am J Ophthalmol 131:699–708PubMedCrossRef
33.
go back to reference Krupin T, Liebmann JM, Greenfield DS, Rosenberg LF, Ritch R, Yang JW (2005) Low-Pressure Glaucoma Treatment Study (LoGTS). Study design and baseline characteristics of enrolled patients. Ophthalmology 112:376–385PubMedCrossRef Krupin T, Liebmann JM, Greenfield DS, Rosenberg LF, Ritch R, Yang JW (2005) Low-Pressure Glaucoma Treatment Study (LoGTS). Study design and baseline characteristics of enrolled patients. Ophthalmology 112:376–385PubMedCrossRef
34.
go back to reference Yip JLY, Aung T, Wong T-Y, Machin D, Khaw PT, Khaw K-T, Seah S, Foster PJ (2007) Socioeconomic status, systolic blood pressure and intraocular pressure: the Tanjong Pagar Study. Br J Ophthalmol 91:56–61PubMedCrossRef Yip JLY, Aung T, Wong T-Y, Machin D, Khaw PT, Khaw K-T, Seah S, Foster PJ (2007) Socioeconomic status, systolic blood pressure and intraocular pressure: the Tanjong Pagar Study. Br J Ophthalmol 91:56–61PubMedCrossRef
35.
go back to reference Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hyussein M (2002) Reduction of intraocular pressure and glaucoma progression results from the early manifest glaucoma trial. Arch Ophthalmol 120(10):1268–1279PubMedCrossRef Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hyussein M (2002) Reduction of intraocular pressure and glaucoma progression results from the early manifest glaucoma trial. Arch Ophthalmol 120(10):1268–1279PubMedCrossRef
37.
go back to reference Tielsch JM, Sommer A, Katz J, Quigley H, Ezrine S (1991) Socioeconomic status and visual impairment among urban Americans. Arch Ophthalmol 109:637–641PubMedCrossRef Tielsch JM, Sommer A, Katz J, Quigley H, Ezrine S (1991) Socioeconomic status and visual impairment among urban Americans. Arch Ophthalmol 109:637–641PubMedCrossRef
39.
go back to reference Adler N, Ostrove J (1999) Socioeconomic status and health: what we know and what we don’t. Ann N Y Acad Sci 896(1):3–15PubMedCrossRef Adler N, Ostrove J (1999) Socioeconomic status and health: what we know and what we don’t. Ann N Y Acad Sci 896(1):3–15PubMedCrossRef
40.
go back to reference Galobardes B, Morabia A, Bernstein MS (2001) Diet and socioeconomic position: does the use of different indicators matter? Int J Epidemiol 30(2):334–340PubMedCrossRef Galobardes B, Morabia A, Bernstein MS (2001) Diet and socioeconomic position: does the use of different indicators matter? Int J Epidemiol 30(2):334–340PubMedCrossRef
41.
go back to reference Kang JH, Willett WC, Rosner BA, Buys E, Wiggs JL, Pasquale LR (2016) Association of dietary nitrate intake with primary open-angle glaucoma: a prospective analysis from the nurses’ health study and health professionals follow-up study. JAMA Ophthalmol 134(3):294–303PubMedPubMedCentralCrossRef Kang JH, Willett WC, Rosner BA, Buys E, Wiggs JL, Pasquale LR (2016) Association of dietary nitrate intake with primary open-angle glaucoma: a prospective analysis from the nurses’ health study and health professionals follow-up study. JAMA Ophthalmol 134(3):294–303PubMedPubMedCentralCrossRef
43.
go back to reference Natsis K, Asouhidou I, Nousios G, Chatzibalis T, Vlasis K, Karabatakis V (2009) Aerobic exercise and intraocular pressure in normotensive and glaucoma patients. BMC Ophthalmol 9:6PubMedPubMedCentralCrossRef Natsis K, Asouhidou I, Nousios G, Chatzibalis T, Vlasis K, Karabatakis V (2009) Aerobic exercise and intraocular pressure in normotensive and glaucoma patients. BMC Ophthalmol 9:6PubMedPubMedCentralCrossRef
44.
go back to reference Wolfs RC, Klaver CC, Ramrattan RS, van Duijn CM, Hofman A, de Jong PT (1998) Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study. Arch Ophthalmol 116(12):1640–1645PubMedCrossRef Wolfs RC, Klaver CC, Ramrattan RS, van Duijn CM, Hofman A, de Jong PT (1998) Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study. Arch Ophthalmol 116(12):1640–1645PubMedCrossRef
45.
go back to reference Awadalla MS, Fingert JH, Roos BE et al (2015) Copy number variations of TBK1 in Australian patients with primary open-angle glaucoma. Am J Ophthalmol 159(1):124–30.e1PubMedCrossRef Awadalla MS, Fingert JH, Roos BE et al (2015) Copy number variations of TBK1 in Australian patients with primary open-angle glaucoma. Am J Ophthalmol 159(1):124–30.e1PubMedCrossRef
Metadata
Title
Migraine headache and other risk factors associated with glaucoma among the adult population living in Armenia: a case–control study
Authors
Aida Giloyan
Vahe Khachadourian
Varsik Hakobyan
Lilit Kirakosyan
Varduhi Petrosyan
Tsovinar Harutyunyan
Publication date
01-12-2024
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-024-03145-2

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