Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Ophthalmology and Therapy
Published in: Ophthalmology and Therapy 1/2019

Open Access 01-03-2019 | Glaucoma | Review

Miniaturization in Glaucoma Monitoring and Treatment: A Review of New Technologies That Require a Minimal Surgical Approach

Authors: H. Burkhard Dick, Tim Schultz, Ronald D. Gerste

Published in: Ophthalmology and Therapy | Issue 1/2019

Login to get access

Abstract

In the management of glaucoma, recent and upcoming innovations have the potential to contribute to both the efficacy of intraocular pressure (IOP) monitoring and the number of available treatment options. These new devices and procedures have two things in common: they are part of the trend in medicine towards miniaturization, and they require a limited surgical procedure to become effective. This review focuses on the Eyemate (Argos) intraocular sensor, which offers a new way to reliably measure 24 h IOP, and on intraocular sustained release systems for pharmacological glaucoma therapy. It also briefly reflects on the miniature implants currently used in minimally invasive glaucoma surgery (MIGS).
Literature
1.
2.
Anzari E. An update on implants for minimally invasive glaucoma surgery (MIGS). Ophthalmol Ther. 2017;6:233–41.CrossRef
3.
Bhamra H, Tsai JW, Huang YW, Yuan Q, Shah JV, Irazoqui P. A subcubic millimeter wireless implantable intraocular pressure monitor microsystem. IEEE Trans Biomed Circuits Syst. 2017;11:1204–15.CrossRef
4.
Brandt JD, DuBiner HB, Benza R, Sall KN, Walker GA, Semba CP. Long-term safety and efficacy of a sustained-release bimatoprost ocular ring. Ophthalmology. 2017;124:1565–6.CrossRef
5.
De Gregorio A, Pedrotti E, Stevan G, Bertoncello A, Morselli S. XEN glaucoma treatment system in the management of refractory glaucomas: a short review on trial data and potential role in clinical practice. Clin Ophthalmol. 2018;12:773–82.CrossRef
6.
Dick HB, Schultz T. New developments in cataract surgery. Klin Monbl Augenheilkd. 2017;234:979–85 (article in German).CrossRef
7.
Flammer J, Mozaffarieh M. What is the present pathogenetic concept of glaucomatous optic neuropathy? Surv Ophthalmol. 2007;52(Suppl 2):S162–73.CrossRef
8.
Fingeret M, Dickerson JE Jr. The role of minimally invasive glaucoma surgery devices in the management of glaucoma. Optom Vis Sci. 2018;95:155–62.CrossRef
9.
10.
Gupta P, Zhao D, Guallar E, Ko F, Boland MV, Friedman DS. Prevalence of glaucoma in the United States: the 2005–2008 National Health and Nutrition Examination Survey. Investig Ophthalmol Vis Sci. 2016;57:2905–13.
11.
12.
Hoban K, Peden R, Megaw R, Halpin P, Tatham AJ. 24-Hour contact lens sensor monitoring of intraocular pressure-related profiles in normal-tension glaucoma and rates of disease progression. Ophthalmic Res. 2017;57:208–15.CrossRef
13.
Kapetanakis VV, Chan MP, Foster PJ, Cook DG, Owen CG, Rudnicka AR. Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis. Br J Ophthalmol. 2016;100:86–93.CrossRef
14.
Kim CY, Park KH, Ahn J, et al. Treatment patterns and medication adherence of patients with glaucoma in South Korea. Br J Ophthalmol. 2017;101:801–7.CrossRef
15.
Kim KH, Lee JO, Du J, Sretavan D, Choo H. Real-time in vivo intraocular pressure monitoring using an optomechanical implant and an artificial neural network. IEEE Sens J. 2017;17:7394–404.CrossRef
16.
Koutsonas A, Walter P, Plange N. Self-tonometry with a telemetric intraocular pressure sensor in patients with glaucoma. Klin Monbl Augenheilkd. 2016;233:743–8 (article in German).PubMed
17.
Koutsonas A, Walter P, Roessler G, Plange N. Long-term follow-up after implantation of a telemetric intraocular pressure sensor in patients with glaucoma: a safety report. Clin Exp Ophthalmol. 2018:46(5):473–9. https://​doi.​org/​10.​1111/​ceo.​13100.
18.
Leidl MC, Choi CJ, Syed ZA, Melki SA. Intraocular pressure fluctuation and glaucoma progression: what do we know? Br J Ophthalmol. 2014;98:1315–9.CrossRef
19.
Lewis RA, Christie WC, Day DG, Craven ER, Walters T, Bejanian M, Lee SS, Goodkin ML, Zhang J, Whitcup SM, Robinson, Bimatoprost SR Study Group. Bimatoprost sustained-release implants for glaucoma therapy: 6-month results from a phase I/II clinical trial. Am J Ophthalmol. 2017;175:137–47.CrossRef
20.
21.
Malihi M, Moura Filho ER, Hodge DO, Sit AJ. Long-term trends in glaucoma-related blindness in Olmsted County, Minnesota. Ophthalmology. 2014;121:134–41.CrossRef
22.
23.
Melki S, Todani A, Cherfan G. An implantable intraocular pressure transducer: initial safety outcomes. JAMA Ophthalmol. 2014;132:1221–5.CrossRef
24.
Molaei A, Karamzadeh V, Safi S, Esfandiari H, Dargahi J, Khosravi MA. Upcoming methods and specifications of continuous intraocular pressure monitoring systems for glaucoma. J Ophthalmic Vis Res. 2018;13:66–71.CrossRef
25.
Mozaffarieh M, Flammer J. New insights in the pathogenesis and treatment of normal tension glaucoma. Curr Opin Pharmacol. 2013;13:43–9.CrossRef
26.
Mozaffarieh M, Grieshaber MC, Flammer J. Oxygen and blood flow: players in the pathogenesis of glaucoma. Mol Vis. 2008;14:224–33.PubMedPubMedCentral
27.
Myers JS, Masood I, Hornbeak DM, Belda JI, Auffarth G, Jünemann A, Giamporcaro JE, Martinez-de-la-Casa JM, Ahmed IIK, Voskanyan L, Katz LJ. Prospective evaluation of two iStent® trabecular stents, one iStent Supra® suprachoroidal stent, and postoperative prostaglandin in refractory glaucoma: 4-year outcomes. Adv Ther. 2018;35:395–407.CrossRef
28.
Newman-Casey PA, Blachley T, Lee PP, Heisler M, Farris KB, Stein JD. Patterns of glaucoma medication adherence over four years of follow-up. Ophthalmology. 2015;122:2010–21.CrossRef
29.
Newman-Casey PA, Robin AL, Blachley T, Farris K, Heisler M, Resnicow K, Lee PP. The most common barriers to glaucoma medication adherence: a cross-sectional survey. Ophthalmology. 2015;122:1308–16.CrossRef
30.
Okeke CO, Quigley HA, Jampel HD, Ying GS, Plyler RJ, Jiang Y, Friedman DS. Interventions improve poor adherence with once daily glaucoma medications in electronically monitored patients. Ophthalmology. 2009;116:2286–93.CrossRef
31.
Osorio-Alayo V, Pérez-Torregrosa VT, Clemente-Tomás R, Olate-Pérez Á, Cerdà-Ibáñez M, Gargallo-Benedicto A, Barreiro-Rego A, Duch-Samper A. Efficacy of the SENSIMED Triggerfish® in the postoperative follow-up of PHACO-ExPRESS combined surgery. Arch Soc Esp Oftalmol. 2017;92:372–8.CrossRef
32.
33.
Paschalis EI, Cade F, Melki S, Pasquale LR, Dohlman CH, Ciolino JB. Reliable intraocular pressure measurement using automated radio-wave telemetry. Clin Ophthalmol. 2014;8:177–85.CrossRef
34.
Pérez-Torregrosa VT, Olate-Pérez Á, Cerdà-Ibáñez M, et al. Combined phacoemulsification and XEN45 surgery from a temporal approach and 2 incisions. Arch Soc Esp Oftalmol. 2016;91:415–21.CrossRef
35.
Pfeiffer N, Garcia-Feijoo J, Martinez-de-la-Casa JM, et al. A randomized trial of a Schlemm’s canal microstent with phacoemulsification for reducing intraocular pressure in open-angle glaucoma. Ophthalmology. 2015;122:1283–93.CrossRef
36.
Pillunat LE, Erb C, Jünemann AG, Kimmich F. Micro-invasive glaucoma surgery (MIGS): a review of surgical procedures using stents. Clin Ophthalmol. 2017;11:1583–600.CrossRef
37.
Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90:262–7.CrossRef
38.
Reitmeir P, Linkohr B, Heier M, et al. Common eye diseases in older adults of southern Germany: results from the KORA-Age study. Age Ageing. 2017;46:481–6.PubMed
39.
Richter GM, Coleman AL. Minimally invasive glaucoma surgery: current status and future prospects. Clin Ophthalmol. 2016;10:189–206.PubMedPubMedCentral
40.
Saheb H, Ahmed II. Micro-invasive glaucoma surgery: current perspectives and future directions. Curr Opin Ophthalmol. 2012;23:96–104.CrossRef
41.
Sunaric-Megevand G, Leuenberger P, Preußner PR. Assessment of the Triggerfish contact lens sensor for measurement of intraocular pressure variations. Acta Ophthalmol. 2014;92:e414–5.CrossRef
42.
43.
Vajaranant TS, Wu S, Torres M, Varma R. The changing face of primary open-angle glaucoma in the United States: demographic and geographic changes from 2011 to 2050. Am J Ophthalmol. 2012;154(303–314):e303.CrossRef
44.
Voskanyan L, García-Feijoó J, Belda JI, Fea A, Jünemann A, Baudouin C, Synergy Study Group. Prospective, unmasked evaluation of the iStent® inject system for open-angle glaucoma: synergy trial. Adv Ther. 2014;31:189–201.CrossRef
45.
Zetterström C, Behndig A, Kugelberg M, Montan P, Lundström M. Changes in intraocular pressure after cataract surgery: analysis of the Swedish National Cataract Register Data. J Cataract Refract Surg. 2015;41:1725–9.CrossRef
Metadata
Title
Miniaturization in Glaucoma Monitoring and Treatment: A Review of New Technologies That Require a Minimal Surgical Approach
Authors
H. Burkhard Dick
Tim Schultz
Ronald D. Gerste
Publication date
01-03-2019
Publisher
Springer Healthcare
Published in
Ophthalmology and Therapy / Issue 1/2019
Print ISSN: 2193-8245
Electronic ISSN: 2193-6528
DOI
https://doi.org/10.1007/s40123-019-0161-2

Other articles of this Issue 1/2019

Ophthalmology and Therapy 1/2019 Go to the issue

Original Research

Intermediate Results of iStent or iStent inject Implantation Combined with Cataract Surgery in a Real-World Setting: A Longitudinal Retrospective Study

Original Research

Preclinical Safety Evaluation of Ophthalmic Viscosurgical Devices in Rabbits and a Novel Mini-Pig Model

Brief Report

Living with Geographic Atrophy: An Ethnographic Study

Original Research

Near Vision Improvement with the Use of a New Topical Compound for Presbyopia Correction: A Prospective, Consecutive Interventional Non-Comparative Clinical Study

Review

Ocular Mucous Membrane Pemphigoid: Current State of Pathophysiology, Diagnostics and Treatment

Case Series

The Ocular Status of Cystinosis Patients Receiving a Hospital Pharmacy-Made Preparation of Cysteamine Eye Drops: A Case Series
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits