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World Journal of Surgery
Published in: World Journal of Surgery 3/2005

01-03-2005 | Invited Commentary

GIST: Not Just for Surgeons Anymore!

Author: Charles Blanke, M.D.

Published in: World Journal of Surgery | Issue 3/2005

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Excerpt

Like most sarcomas, gastrointestinal stromal tumors (GISTs) historically have been best treated by surgeons. Indeed, no other physicians could offer any meaningfully effective therapy, as these tumors are even more radio- and chemotherapy resistant than other connective tissue malignancies. Imatinib mesylate changed everything, and not just for the few thousand GIST patients treated yearly. The discovery that characterizing the molecular driving force behind a tumor could lead to its exploitation as a therapeutic target changed the way we do cancer research. …
Literature
1.
Fletcher, C.D.M., Berman, J.J., Corless, C.L., et al. (2002) “Diagnosis of gastrointestinal stromal tumors: a consensus approach.” Hum. Pathol. 33: 459–465
2.
Kindblom, L-G. Gastrointestinal stromal tumors: Diagnosis, epidemiology, prognosis. Thirty-ninth Annual Meeting of the American Society of Clinical Oncology, Chicago, IL, June 2003
3.
NG, E.H., Pollock, R.E., Munsell, M.F. (1992) “Prognostic factors influencing survival in gastrointestinal leiomyosarcomas: Implications for surgical management and staging.” Ann Surg. 215: 68–77
4.
Mudan, S.S., Conlon, K.C., Woodruff, J.M., et al. (2000) “Salvage surgery for patients with recurrent gastrointestinal sarcoma: Pronostic factors to guide patient selection.” Cancer 88: 66–74
Metadata
Title
GIST: Not Just for Surgeons Anymore!
Author
Charles Blanke, M.D.
Publication date
01-03-2005
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 3/2005
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-004-1085-z

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