Giant cell tumour of the ovary in a 70-year-old nulliparous woman: a case report and review of literature

Excerpt

Giant cell tumour of the ovary is an extremely rare neoplasm that is histologically indistinguishable from the giant cell tumour of bone [1]. The few cases reported occurred in middle-aged and elderly women. Neoplasms that are composed of focally, predominantly or exclusively of osteoclast-like giant cells admixed with variably pleomorphic mononuclear cells have been described in a wide variety of organs [2]. One of the cases described was associated with a serous cyst of the ovary [3], while some were associated with mucinous ovarian tumours [4‐6]. Immunohistochemical studies showed that the osteoclast-like giant cells are positive for CD68, vimentin and alpha-1-antichymotrypsin, while the mononuclear cells are positive for vimentin and PCNA [2, 3]. This is suggestive of the tumour being of mesenchymal origin [3]. …