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European Radiology
Published in: European Radiology 6/2003

01-12-2003 | Neuro

Giant cavernoma of the brain stem: value of delayed MR imaging after contrast injection

Authors: R. Thiex, R. Krüger, S. Friese, E. Grönewäller, W. Küker

Published in: European Radiology | Special Issue 6/2003

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Abstract.

Cavernous angiomas are vascular malformations composed of slowly perfused, sinusoidal vessels which can be located in any part of the central nervous system. Whereas diagnosis is mostly straightforward in typical cases, some lesions may present in unusual locations or with unusual imaging characteristics. Because of the slow perfusion, contrast enhancement is not regarded as a characteristic imaging feature of cavernomas. We report a large brain stem cavernoma with signs of recent bleeding, in which the differential diagnosis against other mass lesions was facilitated by the demonstration of slow, but intense, contrast enhancement on MRI 1 h after contrast injection. We conclude that contrast enhancement in delayed images may contribute to a safe diagnosis of cavernous haemangiomas and should be performed in atypical cases.
Literature
1.
Porter RW, Detwiler PW, Spetzler RF et al. (1999) Cavernous malformations of the brainstem: experience with 100 patients. J Neurosurg 90:50–58PubMed
2.
Wilson CB (1992) Cryptic vascular malformations. Clin Neurosurg 38:49–84PubMed
3.
Zabramski JM, Wascher TM, Spetzler RF et al. (1994) The natural history of familial cavernous malformations: results of an ongoing study. J Neurosurg 80:422–432PubMed
4.
Russell D, Rubinstein L (1963) Pathology of the nervous system, 2nd edn. Williams and Wilkins, New York
5.
Rigamonti D, Spetzler RF (1988) The association of venous and cavernous malformations. Report of four cases and discussion of the pathophysiological, diagnostic, and therapeutic implications. Acta Neurochir (Wien) 92:100–105
6.
Maeder P, Gudinchet F, Meuli R, de Tribolet N (1998) Development of a cavernous malformation of the brain. Am J Neuroradiol 19:1141–1143PubMed
7.
Latchaw RE, Truwit CL, Heros RC (1994) Venous angioma, cavernous angioma and hemorrhage. Am J Neuroradiol 15:1255–1257
8.
Dillon WP (1997) Cryptic vascular malformations: controversies in terminology, diagnosis, pathophysiology, and treatment. Am J Neuroradiol 18:1839–1846PubMed
9.
McCormick WF, Hardman JM, Boulter TR (1968) Vascular malformations ("angiomas") of the brain, with special reference to those occurring in the posterior fossa. J Neurosurg 28:241–251PubMed
10.
Wong JH, Awad IA, Kim JH (2000) Ultrastructural pathological features of cerebrovascular malformations: a preliminary report. Neurosurgery 46:1454–1459PubMed
11.
Kupersmith MJ, Kalish H, Epstein F et al. (2001) Natural history of brainstem cavernous malformations. Neurosurgery 48:47–53PubMed
12.
Amirjamshidi A, Abbassioun K (2000) Radiation-induced tumors of the central nervous system occurring in childhood and adolescence. Four unusual lesions in three patients and a review of the literature. Childs Nerv Syst 16:390–397CrossRefPubMed
13.
Olivero WC, Deshmukh P, Gujrati M (2000) Radiation-induced cavernous angioma mimicking metastatic disease. Br J Neurosurg 14:575–578CrossRefPubMed
14.
Labauge P, Laberge S, Brunereau L, Levy C, Tournier Lasserve E (1998) Hereditary cerebral cavernous angiomas: clinical and genetic features in 57 French families. Societe Francaise de Neurochirurgie. Lancet 352:1892–1897PubMed
15.
Labauge P, Brunereau L, Levy C, Laberge S, Houtteville JP (2000) The natural history of familial cerebral cavernomas: a retrospective MRI study of 40 patients. Neuroradiology 42:327–332CrossRefPubMed
16.
Zhang J, Clatterbuck RE, Rigamonti D, Dietz HC (2000) Mutations in KRIT1 in familial cerebral cavernous malformations. Neurosurgery 46:1272–1277PubMed
17.
Davenport WJ, Siegel AM, Dichgans J et al. (2001) CCM1 gene mutations in families segregating cerebral cavernous malformations. Neurology 56:540–543PubMed
18.
Sarraf D, Payne AM, Kitchen ND, Sehmi KS, Downes SM, Bird AC (2000) Familial cavernous hemangioma: an expanding ocular spectrum. Arch Ophthalmol 118:969–973PubMed
19.
Reyns N, Assaker R, Louis E, Lejeune JP (1999) Intraventricular cavernomas: three cases and review of the literature. Neurosurgery 44:648–654PubMed
20.
Ferrante L, Acqui M, Trillo G, Antonio M, Nardacci B, Celli P (1998) Cavernous angioma of the VIIIth cranial nerve. A case report. Neurosurg Rev 21:270–276PubMed
21.
Bristot R, Santoro A, Fantozzi L, Delfini R (1997) Cavernoma of the cavernous sinus: case report. Surg Neurol 48:160–163CrossRefPubMed
22.
Kim M, Rowed DW, Cheung G, Ang LC (1997) Cavernous malformation presenting as an extra-axial cerebellopontine angle mass: case report. Neurosurgery 40:187–190PubMed
23.
Krief O, Sichez JP, Chedid G et al. (1991) Extraaxial cavernous hemangioma with hemorrhage. Am J Neuroradiol 12:988–990PubMed
24.
Atlas SW, Hurst RW (1996) Intracranial vascular malformations and aneurysms. In: Atlas SW (ed) Magnetic resonance imaging of the brain and spine, 2nd edn. Lippincott-Raven, Philadelphia, pp 516–521
25.
Clatterbuck RE, Moriarity JL, Elmaci I, Lee RR, Breiter SN, Rigamonti D (2000) Dynamic nature of cavernous malformations: a prospective magnetic resonance imaging study with volumetric analysis. J Neurosurg 93:981–986PubMed
26.
Porter PJ, Willinsky RA, Harper W, Wallace MC (1997) Cerebral cavernous malformations: natural history and prognosis after clinical deterioration with or without hemorrhage. J Neurosurg 87:190–197PubMed
27.
Sze G, Krol G, Olsen WL et al. (1987) Hemorrhagic neoplasms: MR mimics of occult vascular malformations. Am J Roentgenol 149:1223–1230
28.
Hayman LA, Fox AJ, Evans RA (1981) Effectiveness of contrast regimens in CT detection of vascular malformations of the brain. Am J Neuroradiol 2:421–425PubMed
Metadata
Title
Giant cavernoma of the brain stem: value of delayed MR imaging after contrast injection
Authors
R. Thiex
R. Krüger
S. Friese
E. Grönewäller
W. Küker
Publication date
01-12-2003
Publisher
Springer-Verlag
Published in
European Radiology / Issue Special Issue 6/2003
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-002-1772-9

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