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Published in: European Radiology 6/2003

01-12-2003 | Gastrointestinal

Rectal inflammation as first manifestation of graft-vs-host disease: radiologic-pathologic findings

Authors: Vito Cantisani, Koenraad J. Mortele, Salvatore G. Viscomi, Jonathan Glickman, Stuart G. Silverman, Pablo R. Ros

Published in: European Radiology | Special Issue 6/2003

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Abstract.

Graft-vs-host disease (GVHD) is a common, life-threatening complication of bone marrow transplantation that frequently involves the gastrointestinal tract. Since symptoms are typically nonspecific, radiologic examination is often performed to reach a diagnosis. To the best of our knowledge, this is the first reported radiologic description of a case of rectal involvement as the first manifestation of GVHD. The differential diagnosis of segmental rectal wall thickening in a patient following bone marrow transplantation should include GVHD.
Literature
1.
go back to reference Ash RC, Casper JT, Chitambar CT et al. (1990) Successful allogenic transplantation of T-cell-depleted bone marrow from closely HLA matched unrelated donors. N Engl J Med 322:485–494PubMed Ash RC, Casper JT, Chitambar CT et al. (1990) Successful allogenic transplantation of T-cell-depleted bone marrow from closely HLA matched unrelated donors. N Engl J Med 322:485–494PubMed
2.
go back to reference Gingrich RD, Ginder GD, Goeken NE et al. (1988) Allogeneic marrow grafting with partially mismatched unrelated marrow donors. Blood 71:1375–1381PubMed Gingrich RD, Ginder GD, Goeken NE et al. (1988) Allogeneic marrow grafting with partially mismatched unrelated marrow donors. Blood 71:1375–1381PubMed
3.
go back to reference Benya EC, Sivit CJ, Quinones RR (1993) Abdominal complications after bone marrow transplantation in children: sonographic and CT findings. Am J Roentgenol 161:1023–1027PubMed Benya EC, Sivit CJ, Quinones RR (1993) Abdominal complications after bone marrow transplantation in children: sonographic and CT findings. Am J Roentgenol 161:1023–1027PubMed
4.
go back to reference Donnelly LF, Morris CL (1996) Acute graft-versus-host disease in children: abdominal CT findings. Radiology 199:265–268 Donnelly LF, Morris CL (1996) Acute graft-versus-host disease in children: abdominal CT findings. Radiology 199:265–268
5.
go back to reference Appleton AL, Sviland L (1993) Current thoughts on the pathogenesis of graft-versus-host disease. J Clin Pathol 46:785–789PubMed Appleton AL, Sviland L (1993) Current thoughts on the pathogenesis of graft-versus-host disease. J Clin Pathol 46:785–789PubMed
6.
go back to reference Slavin RE, Woodruff JM (1974) The pathology of bone marrow transplantation. Pathol Annu 9:291–344PubMed Slavin RE, Woodruff JM (1974) The pathology of bone marrow transplantation. Pathol Annu 9:291–344PubMed
7.
go back to reference McDonald GB, Shulman HM, Sullivan KM, Spencer GB (1986) Intestinal and hepatic complications of human bone marrow transplantation. Part I. Gastroenterology 90:460–477PubMed McDonald GB, Shulman HM, Sullivan KM, Spencer GB (1986) Intestinal and hepatic complications of human bone marrow transplantation. Part I. Gastroenterology 90:460–477PubMed
8.
go back to reference Iqbal N, Salzman D, Lazenby AJ, Wilcox M (2000) Diagnosis of gastrointestinal graft-versus-host-disease. Am J Gastroenterol 95:3034–3038CrossRefPubMed Iqbal N, Salzman D, Lazenby AJ, Wilcox M (2000) Diagnosis of gastrointestinal graft-versus-host-disease. Am J Gastroenterol 95:3034–3038CrossRefPubMed
9.
go back to reference Ferrara JL, Deeg HJ (1991) Graft-versus-host disease. N Engl J Med 324:667–674PubMed Ferrara JL, Deeg HJ (1991) Graft-versus-host disease. N Engl J Med 324:667–674PubMed
10.
go back to reference Patzic SB, Smith C, Kubicka RA, Kaizer H (1991) Bone marrow transplantation: clinical and radiologic aspects. Radiographics 11:601–610PubMed Patzic SB, Smith C, Kubicka RA, Kaizer H (1991) Bone marrow transplantation: clinical and radiologic aspects. Radiographics 11:601–610PubMed
11.
go back to reference Beschorner WE (1984) Destruction of the intestinal mucosa after bone marrow transplantation and graft-versus-host-disease. Surv Synth Pathol Res 3:264–274 Beschorner WE (1984) Destruction of the intestinal mucosa after bone marrow transplantation and graft-versus-host-disease. Surv Synth Pathol Res 3:264–274
12.
go back to reference Maile CW, Frick MP, Crass JR, Snover DC, Weisdork SA, Kersey JH (1985) The plain abdominal radiograph in acute gastrointestinal graft-vs-host disease. Am J Roentgenol 145:289–292 Maile CW, Frick MP, Crass JR, Snover DC, Weisdork SA, Kersey JH (1985) The plain abdominal radiograph in acute gastrointestinal graft-vs-host disease. Am J Roentgenol 145:289–292
13.
go back to reference Fisk JD, Shulman HM, Greening RR et al. (1981) Gastrointestinal radiographic features of human graft-vs-host disease. Am J Roentgenol 136:329–336 Fisk JD, Shulman HM, Greening RR et al. (1981) Gastrointestinal radiographic features of human graft-vs-host disease. Am J Roentgenol 136:329–336
14.
go back to reference Jones B, Kramer SS, Saral R et al. (1988) Gastrointestinal inflammation after bone marrow transplantation: graft-versus-host disease or opportunistic infection? Am J Roentgenol 150:277–281 Jones B, Kramer SS, Saral R et al. (1988) Gastrointestinal inflammation after bone marrow transplantation: graft-versus-host disease or opportunistic infection? Am J Roentgenol 150:277–281
15.
go back to reference Day DL, Carpenter BL (1993) Abdominal complications in bone pediatric bone marrow transplant recipients. Radiographics 13:1101–1112PubMed Day DL, Carpenter BL (1993) Abdominal complications in bone pediatric bone marrow transplant recipients. Radiographics 13:1101–1112PubMed
16.
go back to reference Sviland L, Pearson AD, Eastham EJ et al. (1988) Class II antigen expression by keratinocytes and enterocytes: an early feature of graft-versus-host-disease. Transplantation 46:402–406 Sviland L, Pearson AD, Eastham EJ et al. (1988) Class II antigen expression by keratinocytes and enterocytes: an early feature of graft-versus-host-disease. Transplantation 46:402–406
17.
go back to reference Sviland L, Pearson AD, Green MA et al. (1993) Prognostic importance of histological and immunopathological assessment of skin and rectal biopsies in patients with GVHD. Bone Marrow Transplantation 11:215–218PubMed Sviland L, Pearson AD, Green MA et al. (1993) Prognostic importance of histological and immunopathological assessment of skin and rectal biopsies in patients with GVHD. Bone Marrow Transplantation 11:215–218PubMed
18.
go back to reference Lerner KG, Kao GF, Storb R, Buckner CD, Clift RA, Thomas ED (1974) Histopatology of graft-vs-host reaction (GvHR) in human recipients of marrow from HL-A matched sibling donors. Transplant Procedure 6:367–371 Lerner KG, Kao GF, Storb R, Buckner CD, Clift RA, Thomas ED (1974) Histopatology of graft-vs-host reaction (GvHR) in human recipients of marrow from HL-A matched sibling donors. Transplant Procedure 6:367–371
19.
go back to reference Horton KM, Corl FM, Fishman EK (2000) CT evaluation of the colon: inflammatory disease. Radiographics 20:399–418PubMed Horton KM, Corl FM, Fishman EK (2000) CT evaluation of the colon: inflammatory disease. Radiographics 20:399–418PubMed
20.
go back to reference Otchy DP, Nelson H (1993) Radiation injuries of the colon and rectum. Surg Clin North Am 73:1017–1035PubMed Otchy DP, Nelson H (1993) Radiation injuries of the colon and rectum. Surg Clin North Am 73:1017–1035PubMed
21.
go back to reference Philpotts LE, Heiken JP, Westcott MA, Gore RM (1994) Colitis: use of CT findings in differential diagnosis. Radiology 190:445–449PubMed Philpotts LE, Heiken JP, Westcott MA, Gore RM (1994) Colitis: use of CT findings in differential diagnosis. Radiology 190:445–449PubMed
22.
go back to reference Neiman P, Wasserman PB, Wentworth BB et al. (1973) Interstitial pneumonia and cytomegalovirus infection as complications of human marrow transplantation. Transplantation 15:478–485 Neiman P, Wasserman PB, Wentworth BB et al. (1973) Interstitial pneumonia and cytomegalovirus infection as complications of human marrow transplantation. Transplantation 15:478–485
23.
go back to reference Horton K, Abrams RA, Fishman EK (2000) Spiral CT of colon cancer: imaging features and role in management. Radiographics 20:419–430PubMed Horton K, Abrams RA, Fishman EK (2000) Spiral CT of colon cancer: imaging features and role in management. Radiographics 20:419–430PubMed
Metadata
Title
Rectal inflammation as first manifestation of graft-vs-host disease: radiologic-pathologic findings
Authors
Vito Cantisani
Koenraad J. Mortele
Salvatore G. Viscomi
Jonathan Glickman
Stuart G. Silverman
Pablo R. Ros
Publication date
01-12-2003
Publisher
Springer-Verlag
Published in
European Radiology / Issue Special Issue 6/2003
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-002-1801-8

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